Professor Xiangdong Chen

publisher：姚嘉仪update：2020-12-30views：474

CHEN, XIANGDONG

Associate Professor of Microbial pharmacy

School of Life Sciences and Technology

Phone: 86-25-86185412

Email: chenxd@cpu.edu.cn

WANG, HUI

Research Associate of Microbial pharmacy

School of Life Sciences and Technology

Phone: 86-25-86185412

Email: wanghui@cpu.edu.cn

Research Summary

Associate professor Chen’s research focuses on antimicrobial pharmacodynamics, especially the activities against drug-resistant bacteria, screening of bioactive substances from microorganisms andmicrobial quality controlof pharmaceuticals. The group members include two teachers ChenXiangdong , WangHui, and six graduate students. Our lab has been engaged in antibacterial drug evaluation and screening since 1996.Weestablished clinical isolatesplatforms for antibacterial screening and high throughput screening assay for β-lactamase inhibitor.We have been doing antibacterial activity research both extra-cellular and intracellular, in Vitro and in vivo. The new antimicrobial agents we have studied included category I new drugs such as ceftazidime/tazobactam, L-ornidazole, YF-13 (fluoroquinolones), and category III new drugs such as rufloxacin hydrochloride, sitafloxacin, aspoxicillin sodium, tebipenem pivoxil, etc. The pharmacodynamic research and data processing work for SFDA new drug application were fulfilled.Our lab maintains long-term cooperation with many enterprises and research institutes such as  antibacterial screening of pleuromutilin compounds with Shanghai Pharmaceutical Institute of Chinese Academy of Sciences, anti-Helicobacter pyloricompound NT09 with Neptunus Company, microbial quality control with Yangtze River Pharmaceutical Group.


Education

2001-2005, Ph.D, Microbial and Biochemical Pharmacy, China Pharmaceutical University

1993-1996, M.S., Department of Pharmaceutical Analysis, China Pharmaceutical University

1986-1990, B.S., Microbiology, Fudan University


Academic Experience

2004-  Associate Professor of Microbial and Biochemical Pharmacy, Department of Microbiology, China Pharmaceutical University

2012-2013 Visiting Scholar/Research Fellow of Microbial and Biochemical Pharmacy,Harvard Medical School/ Massachusetts General Hospital

1996-2004 Lecturer of Microbial and Biochemical Pharmacy,Department of Microbiology, China Pharmaceutical University


Awards and Honors

2011 First Prize, for Teaching Achievement Award, China Pharmaceutical University

2008 First Prize, for Backbone teacher of Youth Project, Jiangsu Province

2005 First Prize, for Undergraduate Teaching Excellence Award, China Pharmaceutical University

Publications

Books:

  1. Experiment and Guide for Microbiology, 4th edition, associate chief editor, 2015, Chinese Medical Science and Technology Press, 104-146, 223-228, 230-231.

  2. Microbiology and Immunology, 8th edition, co-editor, 2015, People's Medical Publishing House, 396-437.

  3. Microbiology and Immunology, co-editor, 6thedition, 2019, Chinese Higher Education Press, 430-459.

  4. Pharmaceuticals of Bioengineering, 2nd co-editor, 2019, Science Press, 214-247

  5. Microbiology and Basic Immunology, 2nd edition, co-editor, 2008, Southeast University Press, 134-169.

Papers and Articles:

  1. Construction of Recombinant Escherichia Coli with Hydroxylase System Activity, Pharmaceutical Biotechnology 2019, 26(2) : 95-99

  2. Preparation of calcified alcohols analogues by bioconversion using Pseudonocardia sp., Microbiology China, 2018, 45(10): 2164-2173

  3. Resistant mechanism of polymyxin resistant-Klebsiella pneumoniae, Chinese Journal of Antibiotics, 2018, (43) 11:1443-1448

  4. Isolation and bioactivity studies of endophytic fungi fromT. wilfordii Hook.f., Microbiology China, 2018, 45(2): 413-419

  5. Study on β-Lactamase Genes in Multidrug-Resistant A. baumannii and Insertion Sequence ISAba1,Pharmaceutical Biotechnology, 2015，22(5): 407-411

  6. Pharmacokinetic /pharmacodynamic study of tebipenem pivoxil against Klebsiella pneumoniae in murine lung infection model, Chin J Clin Pharmacol, 2015, 31(4): 272-275

  7. Establishment of MRSA Infection Model in Scald Mice and the Antibacterial Activity of a Novel Pleuromutilin Derivative WS-007,Pharmaceutical Biotechnology, 2014, 21(5) : 416 - 419

  8. Development of High-throughput Screening Assay for β-lactamase Inhibitor. Chinese Journal of Antibiotics, 2013, (38) 2: 102-105

  9. Activity of sitafloxacin against extracellular and intracellular Staphylococcus aureus in vitro and in vivo: comparison with levofloxacin and moxifloxacin. The Journal of Antibiotics, 2012, 65(5):229-36

  10. Study and Practice to Improve Teaching Effect ofPharmaceutical Microbiology Experiment, Pharmaceutical Education, 2017 (33)3: 76-79