博士,生命科学与技术学院,副教授,硕士生导师,江苏省优青。免疫稳态关键调控通路在感染、自身免疫性疾病和代谢性等疾病中的功能及分子调控机制,并针对关键靶标开发新型小分子化合物。已在Cell Reports,Cellular and Molecular Immunology, Molecular Cancer等高水平杂志发表SCI论文十余篇,已授权国家发明专利1项。
1. 类泛素化修饰调控细胞核内cGAS的活性与功能研究,国家自然科学基金面上项目,2022.01-2025.12,主持;
2. ISG15修饰调控cGAS-STING信号通路的功能及机制研究,江苏省自然科学基金优秀青年基金项目,2022.07-2025.06,主持;
3. microRNAs调控cGAS-STING固有免疫信号通路的新功能及分子机制研究,国家自然科学基金青年基金,2019.01-2021.12,主持;
4. microRNAs 对 cGAS-STING 固有免疫信号通路的调控机制及功能研究,江苏省自然科学基金青年基金,2018.07-2021.06,主持;
5. microRNAs通过靶向cGAS调控固有免疫信号转导及功能,中国博士后科学基金面上资助,2018.01-2020.01,主持
6. 环境污染物诱发代谢性疾病的靶标发现及干预策略研究,国家重点研发计划青年科学家项目,2022.12-2027.11,项目骨干
1.Lei Chu#, Chenhui Li#, Yongxing Li, Qiuya Yu, Huansha Yu, Chunhui Li, Wei Meng , Juanjuan Zhu, Quanyi Wang, Chen Wang*, Shufang Cui* (2021): Perillaldehyde Inhibition of cGAS Reduces dsDNA-Induced Interferon Response. Frontiers in Immunology. doi: 10.3389/fimmu.2021.655637.(第一通讯)
2.Qiuya Yu#, Lei Chu#, Yongxing Li, Quanyi Wang, Juanjuan Zhu, Chen Wang*, Shufang Cui* (2021): miR-23a/b suppress cGAS-mediated innate and autoimmunity. Cellular & Molecular Immunology. doi: 10.1038/s41423-021-00668-x. (第一通讯)
3.Shufang Cui#, Qiuya Yu#, Lei Chu, Ye Cui, Ming Ding, Quanyi Wang, Hongyun Wang, Yu Chen, Xing Liu*, Chen Wang* (2020): Nuclear cGAS Functions Non-Canonically to Enhance Antiviral Immunity via recruiting Methyltransferase Prmt5. Cell Reports. doi.org/10.1016/j.celrep.2020.108490. (第一作者)
4.Shufang Cui#, Xin Liao#, Chao Ye, Xin Yin, Minghui Liu, Yeting Hong, Mengchao Yu, Yanqing Liu, Hongwei Liang, Chen-Yu Zhang and Xi Chen* (2017): ING5 suppresses breast cancer progression and is regulated by miR-24. Molecular Cancer. doi: 10.1186/s12943-017-0658-z. (第一作者)
5.Shufang Cui, Biao Sun, Xin Yin, Xia Guo, Dingming Chao, Chunni Zhang, Chen-Yu Zhang*, Xi Chen*, Jizheng Ma* (2017): Time-course responses of circulating microRNAs to three resistance training protocols in healthy young men. Scientific Reports. doi: 10.1038/s41598-017-02294-y. (第一作者)
6.Shu Fang Cui, Cheng Wang, XinYin, Dong Tian, Qiu Ju Lu, Chen-YuZhang*, Xi Chen*and Ji ZhengMa*(2016).Similar Responses of Circulating MicroRNAs to Acute High-Intensity Interval Exercise and Vigorous-Intensity Continuous Exercise. Frontiers in Physiology. doi: 10.3389/fphys.2016.00102. (第一作者)
7.Shu FangCui, Wei Li, Jie Niu, Chen-Yu Zhang*, Xi Chen* and Ji Zheng Ma* (2015). Acute responses of circulating microRNAs to low-volume sprint interval cycling. Frontiers in Physiology. doi: 10.3389/fphys.2015.00311. (第一作者)
8.YaoWei#, Mingzhen Li#, Shufang Cui#, Dong Wang, Chen-Yu Zhang *, Ke Zen * and Limin Li * (2016): Shikonin Inhibits the Proliferation of Human Breast Cancer Cells by Reducing Tumor-Derived Exosomes. Molecules. Doi: 10.3390/molecules21060777. (共同一作)