女，1985年5月生，副教授，硕士研究生导师，毕业于南京师范大学，生物化学与分子生物学博士学位。2013年7月至今，任职中国药科大学生命科学与技术学院生物化学系。主讲《生物化学》、《Being a Biomolecular Scientist 2:Biochemist》课程。研究方向为抗肿瘤蛋白药物制备及作用机制研究。主持纵向课题2项、横向课题2项，授权专利3项。参与国家科技部“重大新药创制”临床前项目、藏医药协同创新项目、山东省自然科学基金等多项省部级课题
| 蛋白药物表达及作用机制研究 |
（1）国家自然科学基金青年基金项目：基于肿瘤EMT炎症微环境的Anti-TNFa-VHH-RGD4C融合纳米抗体设计及作用机制研究，主持，2017.1-2019.12。
（2）江苏省自然科学基金青年基金项目：基于肿瘤内部转移性炎症微环境的TNFα融合纳米抗体设计及对乳腺癌作用研究，主持，2016.7-2019.6。
（3）横向课题项目：新型生发液安全性及功能性评价，主持，2023.1-2024.12。
[1] Kang N, Liang X, Fan B, Zhao C, Shen B, Ji X*, Liu Y*. Endothelial-Specific Molecule 1 Inhibition Lessens Productive Angiogenesis and Tumor Metastasis to Overcome Bevacizumab Resistance. Cancers (Basel). 2022 Nov 18;14(22):5681.
[2] Kang N, Zhou J, Liang X, Li J, Han T, Zhao C, Yang T, Ji X*, Liu Y*. Tumor necrosis factor α inhibition overcomes immunosuppressive M2b macrophage-induced bevacizumab resistance in triple-negative breast cancer. Cell Death Dis. 2020 Nov 19;11(11):993.
[3] Ji X# Han T#, Kang N, Huang S, Liu Y. Preparation of RGD4C fused anti-TNFα nanobody and inhibitory activity on triple-negative breast cancer in vivo. Life Sci. 2020 Nov 1;260:118274.
[4] Ji X#, Wang H#, Chen Y, Zhou J, Liu Y. Recombinant expressing angiopep-2 fused anti-VEGF single chain Fab (scFab) could cross blood-brain barrier and target glioma. AMB Express. 2019 Oct 15;9(1):165.
[5] Qiao Z, Li X, Kang N, Yang Y, Chen C, Wu T, Zhao M, Liu Y*, Ji X*. A Novel Specific Anti-CD73 Antibody Inhibits Triple-Negative Breast Cancer Cell Motility by Regulating Autophagy. Int J Mol Sci. 2019 Feb 28;20(5):1057.
[6] Chen C, Li X, Gu M, Di R, Kang N, Wang L, Lai Y, Liu Y*, Ji X*. Biological characterisation and application of human MTH1 and monoclonal antibody preparation. Oncol Rep. 2019 Mar;41(3):1851-1862. doi: 10.3892/or.2018.6942. Epub 2018 Dec 19. PMID: 30569141.
[7] Xiong C, Mao Y, Wu T, Kang N, Zhao M, Di R, Li X, Ji X*, Liu Y*. Optimized Expression and Characterization of a Novel Fully Human Bispecific Single-Chain Diabody Targeting Vascular Endothelial Growth Factor165 and Programmed Death-1 in Pichia pastoris and Evaluation of Antitumor Activity In Vivo. Int J Mol Sci. 2018 Sep 25;19(10):2900.
[8] Ji X#, Peng Z#, Li X, Yan Z, Yang Y, Qiao Z, Liu Y. Neutralization of TNFα in tumor with a novel nanobody potentiates paclitaxel-therapy and inhibits metastasis in breast cancer. Cancer Lett. 2017 Feb 1;386:24-34.
