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刘玮
职称:副教授
邮箱:liuwei@cpu.edu.cn
学院:生命科学与技术学院
实验室:江宁校区学院实验楼一期217-1室
招生学科:微生物与生化药学
办公室:江宁校区学院实验楼一期210室
个人简历


生物大分子的结构与功能
研究方向


生物大分子的结构与功能
主持在研项目情况

1、 国家重点研发计划,基于成药性特征的微生物天然产物合成生物学创制,科技部,子课题子任务负责人,2018YFA09020002019.7-2024.6,经费104.6万元;

2、 国家自然科学基金面上项目,基于糖组解码和谱效关系的肿节风糖类特征标识研究及在质控中的应用81673589, 2017.1-2020.12,经费52万元;

3、 国家自然科学基金青年基金,基于结构特征的枸杞多糖多元指纹图谱体系的构建及应用313014732014.1-2016.12,经费24万元;

4、 江苏省自然科学基金面上项目,基于糖链编辑及遗传密码扩增的蛋白聚糖的分子构建及评价,BK201913172019.7-2022.6,经费10万元;

5、 企业横向项目,枸杞多糖中糖类检测方法的建立及方法学验证,2023.10-2024.10,经费15万元。

近年代表性科研成果

1. Cai Yang1, Si Zhenyuan1, Jiang Ying,Ye Meng, Wang Feng, Yang Xiaobing, Yu Juping*, Gao Xiangdong**, Liu Wei***. Structure-activity relationship of low molecular Astragalus membranaceus polysaccharides produced by Bacteroides. Carbohydrate polymers. 2023,121036, 316C.

2. Si Zhenyuan1, Cai Yang1, Zhao Lang, Han Lu, Wang Feng, Yang Xiaobing, Gao Xiangdong*, Meiling Lu**, and Liu Wei***. Structure and function characterization of the α-L-arabinofuranosidase from the white-rot fungus Trametes hirsuta.Applied Microbiology and Biotechnology. 2023, 107, 3967-3981.

3. Ye Meng, Feng Qi, Jiang Ying, Wang Feng, Shi Xuexia, Yang Xiaobing, Gao Xiangdong *, and Liu Wei **. Structure characterization and anti-rheumatoid arthritis activity of a polysaccharide from Notopterygium incisum. Molecular Nutrition and Food Research,2023, 67(15):2200713.

4. Feng Qi 1, Si Yu 1, Zhu Lingling, Wang Feng, Fang Junqiang, Pan Chun, Gao Xiangdong *, Liu Wei **. Anti-inflammatory effects of a SERP 30 polysaccharide from the residue of Sarcandra glabra against lipopolysaccharide-induced acute respiratory distress syndrome in mice, Journal of Ethnopharmacology, 2022, 293,115262.

5. Yu Juping 1, Ye Meng 1, Li Kaidong, Wang Feng, Shi Xuexia , Pan Chun, Yang Xiaobing, Gao Xiangdong *, Liu Wei **. Fragments of a pectin from Arctium lappa L: Molecular properties and intestinal regulation activity. Journal of Functional Food, 2022, 88, 104900.

6. Liu Wei 1, Gong Xingqun1, Luo Jianhua, Jiang Liangliang, Lu Weisheng, Pan Chun, Yao Wenbing, Gao Xiangdong*, Tian Hong **. A purified acidic polysaccharide from Sarcandra glabra as vaccine adjuvant to enhance anti-tumor effect of cancer vaccine. Carbohydrate Polymers, 2021, 263, 117967.

7. Tang Shuai 1, Liu Wei 1, Zhao Qianqian, Li Kaidong, Zhu Jingyi, Yao Wenbing *, Gao Xiangdong **, Combination of polysaccharides from Astragalus membranaceus and Codonopsis pilosula ameliorated mice colitis and underlying mechanisms. Journal of Ethnopharmacology, 2021, 264, 113280.

8. Ye Meng, Yu Juping, Shi Xuexia, Zhu Jingyi, Gao Xiangdong*, Liu Wei **. Polysaccharide catabolism by the human gut bacterium-Bacteroides thetaiotaomicron: advances and perspectives. Critical Reviews in Food Science and Nutrition,2021, 61(21):3569-3588.

9. Sun Xuyang, Zhao Qianqian, Si Yu, Li Kaidong, Zhu Jingyi, Gao Xiangdong*, Liu Wei **. Bioactive structural basis of proteoglycans from Sarcandra glabra based on spectrum-effect relationship. Journal of Ethnopharmacology, 2020, 259, 112941.

10. Liu Wei 1, Tang Shuai1, Zhao Qianqian, Zhang Wanyue, Li Kaidong, Yao Wenbing*, Gao Xiangdong **. The α-D-glucan from marine fungus Phoma herbarum YS4108 ameliorated mice colitis by repairing mucosal barrier and maintaining intestinal homeostasis. International Journal of Biological Macromolecules. 2020,149: 1180-1188.