陆美玲，女，1985年生。副教授，硕士生导师。2012年中国药科大学（美国德州大学医学分部）联合培养博士。曾获2019年第九届“吾爱吾师”活动最受学生喜爱的老师奖、2021年iGEM(国际基因工程机器大赛) 本科生金奖团队第一指导教师及2022年第一届金斯瑞奖教金奖。目前的主要研究方向是采用多学科交叉的研究思路结合X-射线晶体学及冷冻电镜技术（1）解析新型CRISPR-Cas系统效应复合物的结构及作用机制并探究及其在原核及真核细胞中的基因编辑应用潜力（2）研究不同细菌防御系统及其交互的作用机制并由此探索新的抗菌策略。（3）基于蛋白质晶体X-射线衍射的药物靶点蛋白及其抑制剂作用机制的研究。
| 细菌防御系统的机制研究及其应用 |
1.“基于成药性特征的微生物天然产物合成生物学创制”2018YFA0902000 重点研究计划任务负责人2019.07-2024.06
2.“病理机制研究驱动的儿童罕见病药物筛选及研发”SQ2023YFC2700057 重点研究计划任务负责人2023.12-2026.11
3. “新型基因编辑体系挖掘、开发与机制解析”SQ2023YFC3400181）重点研究计划任务负责人2024.01-2028.12
4. ZL202211136496.6专利转让（一种I-B型CRISPR-Cascade-Cas3基因编辑系统及应用）合同金额1000万。
5. “双羰基还原酶的发现、催化机制及药物生物合成应用” 2019年度江苏省科学技术奖 二等奖（排名第三）
1. Ling Zhao, Yuncong Xu, Manting Chen, Lingrui Wu, Meng Li, Yuanyuan Lu, Meiling Lu#, Yijun Chen#, Xuri Wu#. Design of a chimeric glycosyltransferase OleD for the site-specific O monoglycosylation of 3-hydroxypyridine in nosiheptide. Microb Biotechnol. 2023, 16(10):1971-1984.
2. Kuojun Zhang, Tianyu Wang, Maotian Li, Mu Liu, He Tang, Lin Wang, Ke Ye, Jiamei Yang, Sheng Jiang, Yibei Xiao, Youhua Xie, Meiling Lu#, Xiangyu Zhang#. Discovery of quinazolin-4-one-based non-covalent inhibitors targeting the severe acute respiratory syndrome coronavirus 2 main protease (SARS-CoV-2 M). Eur J Med Chem. 2023, 257:115487.
3. Zhenyuan Si, Yang Cai, Lang Zhao, Lu Han, Feng Wang, Xiaobing Yang, Xiangdong Gao, Meiling Lu#, Wei Liu#. Structure and function characterization of the Alpha-L-arabinofuranosidase from the white-rot fungus Trametes hirsuta. Appl Microbiol Biotechnol. 2023, 107(12):3967-3981.
4. Xiaoke Wang, Qinling Yuan, Wenxuan Zhang, Suyu Ji, Yang Lv, Kejing Ren, Meiling Lu#, Yibei Xiao#. Sequence specific integration by the family 1 casposase from Candidatus Nitrosopumilus koreensis AR1. Nucleic Acids Res. 2021, 49(17):9938-9952.
5. Chengchang Zhang*, Meiling Lu*, Lin Lin, Zhangjian Huang, Rongguang Zhang, Xuri Wu, Yijun Chen. Riboflavin Is Directly Involved in N-Dealkylation Catalyzed by Bacterial Cytochrome P450 Monooxygenases. Chembiochem. 2020, 21(16):2297-2305.
6. Xiao-Kun Gu, Xin-Rui Li, Mei-Ling Lu#, Hui Xu#. Lithium promotes proliferation and suppresses migration of Schwann cells. Neural Regen Res. 2020, 15(10):1955-1961.
7. Meiling Lu*, Qiong Cheng*, Zijian Fang, Sheng Yi. Analysis of biological functional networks during sciatic nerve repair and regeneration. Mol Cell Biochem. 2018, 439(1-2):141-150.
8. Xinshuo Wang, Zijian Fang, Anlin Wang, Cheng Luo, Xiaodong Cheng#, Meiling Lu#. Lithium Suppresses Hedgehog Signaling via Promoting ITCH E3 Ligase Activity and Gli1-SUFU Interaction in PDA Cells. Front Pharmacol. 2017, 8:820.
9. Xinshuo Wang, Cheng Luo, Xiaodong Cheng#, Meiling Lu#. Lithium and an EPAC-specific inhibitor ESI-09 synergistically suppress pancreatic cancer cell proliferation and survival. Acta Biochim Biophys Sin. 2017, 49(7):573-580.
10. Meiling Lu*, Yan Huang*, Mark A White*, Xuri Wu, Nan Liu, Xiaodong Cheng, Yijun Chen. Dual catalysis mode for the dicarbonyl reduction catalyzed by diketoreductase. Chem Commun (Camb). 2012, 48(92):11352-4.
