抗感染药理

[1] 国家自然科学基金青年项目，81803591，构效优化的新型抗菌肽MSI-1抗耐甲氧西林金黄色葡萄球菌的机制研究，2019/01-2021/12，21.9万元，主持

[2] 江苏省自然科学基金青年项目，BK20180563，新型抗耐药菌多肽MSI-1的活性及机制研究，2018/07-2021/6，20万元，主持

[3] 中国博士后科学基金第13批特别资助（站中），2020T130723，基于MCR-1靶点的抗菌肽MSI-1抗mcr-1多粘菌素耐药感染的分子机制，2020/01-2021/12，18万元，主持

[4] 中央高校基本业务费（重点项目），2632021ZD07，抗菌肽 MSI-1 通过干预 MCR-1 对细菌 Lipid A 的修饰抑制mcr-1多黏菌素耐药细菌免疫逃逸的机制研究，2021/01-2022/12，15万元，主持

[5] 江苏省科协，tj1288，2020年江苏省科协青年科技人才托举工程资助培养项目，2020/08-2022/06，3万元，主持

[6] 中国博士后科学基金第62批面上资助，1600010009，基于宿主防御的多肽抗H. pylori感染的机制研究，2018/01-2020/01，5 万元，主持

[7] “十三五” 重大新药创制科技重大专项（耐药菌防治药物品种及共性关键技术研发）， 2019ZX09721001-004-005，I类新药抗真菌多肽PL-18和抗耐药菌多肽Cbf-14临床前研究，2019/01-2021/12，244.42万元，骨干成员，划拨经费30万元

[8] 国家自然科学基金面上项目，82173863，基于MCR-1修饰LPS介导的细菌免疫逃逸探讨新结构多肽MSI-1抗多黏菌素耐药感染的机制，2022/01-2025/12，55 万元，骨干成员，划拨经费25万

[9] 国家自然科学基金面上项目，81673483，基于多靶点的多肽抗耐药性细菌感染的机制研究，2017/01-2020/12，45万元，骨干成员，划拨经费20万元

[1] Xinyue Ye, Jian Wang, Pengfei Xu, Xiaoqian Yang, Qixue Shi, Genyan Liu, Zhaoshi Bai, Changlin Zhou^*, Lingman Ma^*, Peptide MSI- 1 inhibited MCR- 1 and regulated outer membrane vesicles to combat immune evasion of Escherichia coli. Microbial Biotechnology. 2023; 16:1755-1773.

[2] Liping Wang, Mengyuan Liu, Yixin Qi, Jian Wang, Qixue Shi, Xiaolin Xie, Changlin Zhou^*, Lingman Ma^*. hsdSA regulated extracellular vesicle-associated PLY to protect Streptococcus pneumoniae from macrophage killing via LAPosomes. Microbiol Spectr. 2024 Jan 11;12(1): e0099523.[3] Ye Xinyue^#, Huang Ya^#, Zhou Chenyu, Liu Xiaoyun, Zhao Wenxuan, Zhao Xiurong, Xie Xiaolin, Wang Liping, Bai Zhaoshi^*, Zhou Changlin^*, Ma Lingman^*. MSI-1 combats drug-resistant S. aureus by affecting bacterial viability and inhibiting carotenoid pigment production. Microbiological Research. 2021 Oct 27; 255: 126909.

[4] Bo Huang, Zhaoshi Bai*, Xinyue Ye, Chenyu Zhou, Xiaolin Xie, Yuejiao Zhong, Kejiang Lin^*, Lingman Ma^*. Structural analysis and binding sites of inhibitors targeting the CD47/SIRPα interaction in anticancer therapy. Comput Struct Biotechnol J. 2021 Oct 1;19:5494-5503.

[5] Zhaoshi Bai, Qing Zhou, Huayun Zhu, Xinyue Ye, Pingping Wu^*, Lingman Ma^*. QTMP, a Novel Thiourea Polymer, Causes DNA Damage to Exert Anticancer Activity and Overcome Multidrug Resistance in Colorectal Cancer Cells. Front Oncol. 2021 May 28;11:667689.

[6] Lingman Ma^#, Xinyue Ye^#, Pengbo Sun, Pengfei Xu, Liping Wang, Zixiang Liu, Xiaowei Huang, Zhaoshi Bai^*, Changlin Zhou^*, Antimicrobial and antibiofilm activity of the EeCentrocin 1 derived peptide EC1-17KV via membrane disruption, EBioMedicine, 2020, 55: 102775.

[7] Lingman Ma^#, Xin Xie^#, Hanhan Liu, Ya Huang, Haomin Wu, Meiling Jiang, Pengfei Xu, Xinyue Ye, Changlin Zhou^*, Potent antibacterial activity of MSI-1 derived from the magainin 2 peptide against drug-resistant bacteria, Theranostics, 2020, 10(3):1373-1390.

[8] Meiling Jiang, Xiaoqian Yang, Haomin Wu, Ya Huang, Jie Dou, Changlin Zhou^*, Lingman Ma^*, An active domain HF-18 derived from hagfish intestinal peptide effectively inhibited drug-resistant bacteria in vitro/vivo, Biochemical Pharmacology, 2020, 172: 113746.

[9] Qian Yu^#, Minda Zhang^#, Qidi Ying, Xin Xie, Shuwen Yue, Qing Wei, Zhaoshi Bai^*, Lingman Ma^*. Decrease of AIM2 mediated by luteolin contributes to non-small cell lung cancer treatment. Cell Death & Disease. 2019 Mar 4;10(3):218.

[10] Lingman Ma, Yanrong Wang, Mengxiao Wang, Yuwei Tian, Wei Kang, Hanhan Liu, Hui Wang, Jie Dou^*, Changlin Zhou^*, Effective antimicrobial activity of Cbf-14, derived from a cathelin-like domain, against penicillin-resistant bacteria, Biomaterials, 2016, 87:32-45.