女,博士,副教授,硕士生导师,密西根大学访问学者。
主要从事海洋真菌来源天然抗菌成分及其机制研究:从来自于中国南海海域中分离鉴定了多株海洋微生物,从海洋青霉和曲霉等优势菌株中筛选了不同抗菌活性成分,并对上述活性成分的作用机制和后续开发进行了研究探索。近年来开展了基于代谢组学的复杂疾病(如抑郁症、糖尿病、卵巢早衰等)病理基础研究。
主持并参与了多项国家级科研项目工作,包括国家自然科学基金、国家重点研发计划专项、科技部科技型中小企业创新基金小额资助项目、科技部863重大课题等。已发表SCI研究论文10余篇,申请专利多项。
基于代谢的疾病机制及诊疗指标研究 |
1)重组鲨肝刺激物类似物抗肝纤维化作用机制研究(国家自然科学基金青年项目,主持,30801454)
2)海洋微生物候选药物的高效发现与创制(国家重点研发计划“深海关键技术与装备”专项,参与,2018YFC0311005)
3)具有多靶点受体激动活性的多肽药物分子开发(技术开发,校合2023-生002)
4)卵巢早衰检测生物标志物研究(技术开发,校合2022-生011)
1) Hanxiang Jiang, Jiaqin Chen, Xinyang Du, Dong Feng, Yanjun Zhang, Jiangfeng Qi, Yajing He, Zhilong An, Yuanyuan Lu, Chun Ge*, Ying Wang*. Unveiling Synergistic Potency: Exploring Butyrolactone I to Enhance Gentamicin Efficacy against Methicillin-Resistant Staphylococcus aureus (MRSA) Strain USA300. ACS Infectious Diseases. 2024, 10 (1):196.
2) Yibo Xu, Dongyang Wang, Qianqian Lv, Peng Fu, Ying Wang,* Weiming Zhu*. Phaeochromycins I−K, Three Methylene-Bridged Dimeric Polyketides from Streptomyces sp. 166#. ACS Omega. 2023, 8 (1): 1542.
3) Jiaqin Chen, Dong Feng, Yuanyuan Lu, Yanjun Zhang, Hanxiang Jiang,Man Yuan, Yifan Xu, Jianjun Zou, Yubing Zhu, Jingjing Zhang, Chun Ge*, Ying Wang*. A Novel Phenazine Analog, CPUL1, Suppresses Autophagic Flux and Proliferation in Hepatocellular Carcinoma: Insight from Integrated Transcriptomic and Metabolomic Analysis . Cancers, 2023, 15(5): 1607.
4) Chaoyi Chen, Jiangfeng Qi, Yajing He, Yuanyuan Lu, Ying Wang*. Genomic and Chemical Profiling of B9, a Unique Penicillium Fungus Derived from Sponge. Journal of Fungi, 2022, 8(7): 686.
5) Jiangfeng Qi, Chaoyi Chen, Yajing He, Ying Wang*. Genomic Analysis and Antimicrobial Components of M7, an Aspergillus terreus Strain Derived from the South China Sea [J]. Journal of Fungi, 2022, 8(10): 1051.
6) Huanhuan Li, Xinyang Du, Chaoyi Chen, Jiangfeng Qi, Ying Wang*. Integrating transcriptomics and metabolomics analysis on kojic acid combating Acinetobacter baumannii biofilm and its potential roles. Microbiological Research. 2022; 254(1):126911.
7) Yaru Gao, Xinyang Du, Huanhuan Li, Ying Wang*. Genome sequence of Aspergillus flavus A7, a marine-derived fungus with antibacterial activity. Genome. 2021;64 (7):719–733.
8) Xinyang Du, Huanhuan Li, Jiangfeng Qi, Chaoyi Chen, Yuanyuan Lu, Ying Wang*. Genome mining of secondary metabolites from a marine-derived Aspergillus terreus B12. Archives of Microbiology, 2021; 203(9):5621.
9) Min Sha, Yaru Gao, Can Deng, Yuemeng Wan, Yuan Zhuang, Xiaochuan Hu, Ying Wang*. Therapeutic effects of AdipoRon on liver inflammation and fibrosis induced by CCl4 in mice. International Immunopharmacology. 2020; 79: 106157.
10) 王颖,金国虔,祁江峰. 海洋来源具有抗菌作用的土曲霉M7及其次级代谢产物的分离及应用. 中国发明专利:ZL202110949984.8.