吴旭日，男，博士，副教授，硕士/博士研究生导师。
2011年毕业于中国药科大学微生物与生化药学专业，获博士学位。现为中国药科大学生命科学与技术学院副教授，主要从事药物合成生物学研究工作。讲授《生物化学》和《药物合成生物学》等课程。入选江苏省“六大人才高峰”B类、江苏省“333高层次人才培养工程”第三层次、江苏高校“青蓝工程”优秀青年骨干教师等人才计划。获江苏省科学技术二等奖1项（2/6）。为Plos One学术编辑，《中国药科大学学报》青年编委；ACS Catal.、J. Agric. Food Chem.、Food Chem.、Appl. Microbiol. Biotechnol.、ChemBioChem、《中国药科大学学报》等多种学术期刊审稿人。发表SCI论文超过30篇，申请PCT和中国发明专利26项，其中已获授权11项。先后主持国家级和企业委托项目多项。
药物合成生物学
[1] 国家重点研发计划项目子课题：以提高水溶性为导向的硫肽类化合物衍生物定向生物合成 在研
[2] 国家自然科学基金面上项目：以改善结构稳定性为导向的诺卡沙星衍生物定向生物合成 在研
[3] “重大新药创制”国家科技重大专项子课题：基于生物合成途径改造的关键技术和HXSW-101临床前研究 已结题
[1] Du, Y.L. #, Xia, Y. #, Wu, L.R., Chen, L., Rong, J.L., Fan, J.T., Chen, Y. J., Wu, X. R*. Selective biosynthesis of a rhamnosyl nosiheptide by a novel bacterial rhamnosyltransferase. Microb. Biotechnol. 2024, 00:e14412.
[2] Zhao, L. #, Xu, Y. C. #, Chen, M. T., Wu, L.R., Li, M., Lu, Y. Y., Lu, M. L., Chen, Y. J., Wu, X. R*. Design of a chimeric glycosyltransferase OleD for the site-specific O-monoglycosylation of 3- hydroxypyridine in nosiheptide. Microb. Biotechnol. 2023, 16(10): 1971-1984.
[3] Zhang, B. #, Jin, W.Z. #, Zhang, Y.Y., Dai, Y., Li, H., Sun, Y,Z., Wu, X.R.*, Luo J.*, Chen, Y.J.* A type I/type III PKS hybrid generates Cinnamomycin A-D. Org. Lett., 2023, 25: 2560-2564.
[4] Su, Y.X., Li, Z.L., Zhao, Y.H., Chen, Y.J., Luo, C., Wu, X.R.* Enzymatic hydrolyzation of mogrosides in Luo Han Guo extract by NKA-adsorbed snailase improves its sensory profile. Food Chem., 2022, 390: 133205.
[5] Xu, Y.C.#, Liu, S.Q. #, Bian L.Y. #, Li Z.L., Luo C., Chen, Y.J.*, Wu, X.R.* Engineering of a UDP-Glycosyltransferase for the Efficient Whole-Cell Biosynthesis of Siamenoside I in Escherichia coli. J. Agric. Food. Chem., 2022, 70(5): 1601-1609. doi: 10.1021/acs.jafc.1c07699.
[6] Xu, Y.C.#, Zhao, L.#, Chen, L., Du, Y.L., Lu, Y.Y., Luo, C., Chen, Y.J. *, Wu, X.R.* Selective enzymatic α-1,6-monoglucosylation of mogroside IIIE for the bio-creation of α-siamenoside I, a potential high-intensity sweetener. Food Chem., 2021, 359: 129938.
[7] Zhang, B., Bian, L.Y., Huang, P.Y., Zhao, L., Chen, Y.J. *, Wu, X.R.* Efficient whole-cell biosynthesis of L-gulose by coupling mannitol-1-dehydrogenase with NADH oxidase. Enzyme Microb. Tech., 2021, 148: 109815.
[8] Zhao, L.#, Wang, Y. #, Li, Z.L., Wang, X.N., Chen, Y.J. *, Wu, X.R. * Enzymatic monoglucosylation of rubusoside and the structure−sweetness/taste relationship of monoglucosyl derivatives. J. Agric. Food Chem. 2020, 68, 8702-8709.
[9] Zhang, C.C., Lu, M.L., Lin L., Huang, Z.J., Zhang, R.G., Wu, X.R.* Chen, Y.J.* Riboflavin is directly involved in N-dealkylation catalyzed by bacterial cytochrome P450 monooxygenases. ChemBioChem, 2020, 21(16): 2297-2305.
Wu, X.R.,# Jin, L.,# Zhang, H., Tong, R.N., Ma, M. & Chen, Y.J.* Identification of truncated form of NosP as a transcription factor to regulate the biosynthesis of nosiheptide. FASEB J. 2018, 32(1): 453-465.
