主持课题

l 国家自然科学基金面上项目，幽门螺杆菌疫苗CCF诱导胃组织驻留型记忆T细胞形成机制及免疫保护作用研究，2020.01-2023.12；

l 国家自然科学基金青年项目，，新型佐剂嵌合鞭毛蛋白（CF）在幽门螺旋杆菌多表位疫苗CCU中的佐剂效应及作用机制研究，2016.01-2018.12；

l 宁夏回族自治区重点研发计划项目子课题，幽门螺旋杆菌感染性胃病生物技术药物及快速诊断技术研发；2019.12- 2022.12；

l 海南省卫生健康科技创新联合项目重点项目子课题，抗幽门螺杆菌mRNA疫苗及circRNA疫苗的研究与开发，2024.01-2027.12；

参与课题

l 国家重点研发计划子课题，2017YFD0400303，膳食成分及肠道微生物的免疫调节作用研究，2017.07- 2020.12；

l 企业横向课题，mRNA肿瘤疫苗设计，2023.12-2024.06。

(1) Zhenyan Miao^#, Jifei Li,^# Yu Wang, Mingqin Shi, Xiao Gu, Xuanqi Zhang, Fang Wei, Xinying Tang*, Lufeng Zheng* and Yingying Xing*.Hsa_circ_0136666 stimulates gastric cancer progression and tumor immune escape by regulating the miR-375/PRKDC Axis and PD-L1 phosphorylation. Molecular Cancer.2023, 22(205): 1-19. (SCI IF=37.3)

(2) Chupeng Hu^#; Wei Liu; Ningyin Xu; An Huang; Zhenxing Zhang; Menghui Fan; Guojing Ruan; Yue Wang; Tao Xi & Yingying Xing*. Silk fibroin hydrogel as mucosal vaccine carrier: induction of gastric CD4+TRM cells mediated by inflammatory response induces optimal immune protection against Helicobacter felis. Emerging Microbes & Infections. 2020, 9(1): 2289-2302. (SCI IF=5.776)

(3) Zhenxing Zhang ^#; Simiao Chen; Menghui Fan; Guojing Ruan; Tao Xi; Lufeng Zheng; Le Guo, Feng Ye; Yingying Xing*. Helicobacter pylori induces gastric cancer via down-regulating miR-375 to inhibit dendritic cell maturation, Helicobacter, 2021;00:e12813.1-13. (SCI IF=5.753)

(4) Haiwei Ni^#; Hai Qin1Cheng Sun; Yichen Liu; Guojing Ruan; Qianqian Guo; Tao Xi*;Yingying Xing* and Lufeng Zheng*. MiR-375 reduces the stemness of gastric cancer cells through triggering ferroptosis, Stem Cell Research & Therapy, 2021, 12:325. (SCI IF=6.832)

(5) Guojing Ruan^#; Haiwei Ni; Hai Qin; Simiao Chen; Xinyue Gu; Jiamin Shang; Yantong Zhou; Xi Tao; Lufeng Zheng; Yingying Xing*,Tumor Immune Microenvironment and Its Related miRNAs in Tumor Progression, Frontiers in Immunology, 2021, 12：Article 624725. (SCI IF=7.561)