1) Weixian Kong#, Jiawen Chen#, Xinjia Ruan#, Xie Li, Xiaozhi Xu, Mengmeng Bao, Yuru Shao, Xiaohong Bian, Ruiyan Li, Qizhou Jiang, Yubin Zhang, Zhe Li*, Fangrong Yan*, Junmei Ye*. Cardiac Injury Activates STING Signaling via Upregulating SIRT6 in Macrophages After Myocardial Infarction. Life Sciences. (IF=6.1)（2024）
2) Kong W#, Peng Y#, Ji C#, Liu Z, Gao S, Zhang Y, Chen J, Li X, Bao M, Zhang Y, Jiang Q, Wang F, Li Z*, Bian X*, Ye J*. Akt2 deficiency alleviates oxidative stress in the heart and liver via upregulating SIRT6 during high-fat diet-induced obesity. Clin Sci (Lond). 2023 May 15:CS20230433. Clin Sci (Lond). 2023 May 31;137(10):823-841. (IF=6.0). doi: 10.1042/CS20230433.
3) Shuya Gao#, Qingchen Yang#, Yue Peng, Weixian Kong, Zekun Liu, Zhe Li, Jiawen Chen, Mengmeng Bao, Xie Li, Yubin Zhang, Xiaohong Bian, Liang Jin, Hanwen Zhang, Yuexin Zhang, Daniel Sanchis*, Fangrong Yan*, Junmei Ye*. SIRT6 regulates obesity-induced oxidative stress via ENDOG/SOD2 signaling in the heart. Cell Biol Toxicol. . 2023 Aug;39(4):1489-1507.
doi: 10.1007/s10565-022-09735-z. (IF=6.819)
4) Shuya Gao#, Qingchen Yang#, Zekun Liu, Weixian Kong, Jiawen Chen, Xie Li, Yue Peng, Mengmeng Bao, Xiaohong Bian, Yuexin Zhang, Qizhou Jiang, Zhe Li, Yubin Zhang*, Fangrong Yan*, Junmei Ye*. Metformin alleviates HFD-induced oxidative stress in hepatocyte via activating SIRT6/PGC-1α/ENDOG signaling. Clin Sci (Lond). 2022, Nov 30;136(22):1711-1730. (IF=6.0)
doi: 10.1042/CS20220242.
5) Yue Peng, Qingchen Yang, Shuya Gao, Zekun Liu, Weixian Kong, Xiaohong Bian, Zhe Li*, Junmei Ye*. IL-6 protects cardiomyocytes from oxidative stress at the early stage of LPS-induced sepsis. Biochem Biophys Res Commun. 2022 May 7;603:144-152.
doi: 10.1016/j.bbrc.2022.03.013. (IF=3.575)
6) Mengxiao Wang, Bingbing Li, Fujian Qin, Junmei Ye*, Liang Jin*. Obesity induced Ext1 reduction mediates the occurrence of NAFLD. Biochem Biophys Res Commun. 2022 Jan 22;589:123-130.
doi: 10.1016/j.bbrc.2021.12.017. (IF=3.575)
7) Xiaofan Lu#, Caoyu Ji#, Liyun Jiang, Yue Zhu, Yujie Zhou, Jialin Meng, Jun Gao, Tao Lu*, Junmei Ye*, Fangrong Yan*. Tumour microenvironment-based molecular profiling reveals ideal candidates for high-grade serous ovarian cancer immunotherapy. Cell Prolif . 2021 Mar;54(3):e12979.
doi: 10.1111/cpr.12979. （IF=8.755）
8) Miao Chen#, Caoyu Ji#, Qingchen Yang, Shuya Gao, Yue Peng, Zhe Li, Xingyu Gao, Yaoting Li, Nan Jiang, Yubin Zhang, Xiaohong Bian, Caiping Chen, Kaidi Zhang, Daniel Sanchis*, Fangrong Yan*, Junmei Ye*. AKT2 regulates development and metabolic homeostasis via AMPK-dependent pathway in skeletal muscle. Clin Sci (Lond). 2020 Sep 18;134(17):2381-2398.
doi: 10.1042/CS20191320.（IF=6.124）
9) Chen D#, Li Z#, Bao P, Chen M, Zhang M, Yan F, Xu Y, Ji C, Hu X, Sanchis D*, Zhang Y*, Ye J*. Nrf2 deficiency aggravates Angiotensin II-induced cardiac injury by increasing hypertrophy and enhancing IL-6/STAT3-dependent inflammation. Biochim Biophys Acta Mol Basis Dis. 2019 Jun1; 1865(6):1253-1264.
doi: 10.1016/j.bbadis.2019.01.020.（IF=5.108）
10) Shuai Yang#, Dandan Chen#, Fan Chen, Xinmei Zhao, Yubin Zhang, Zhe Li, Liang Jin, Yitao Xu, Daniel Sanchis, Junmei Ye. Deletion of AKT2 preserves cardiac function by blocking IL-6-mediated injury and restores blood pressure during angiotensin II/high salt diet-induced hypertension. J Hypertension. 2018 Apr;36(4): 834-846. doi: 10.1097/HJH.0000000000001613.（IF=4.081）
| 糖尿病性心肌及肝脏损伤分子机制；心肌梗死后心肌细胞修复及再生；心力衰竭的分子机制及治疗靶标。 |
1. 江苏省面上基金，（编号：BK20191324）：2019年7月—2022年6月，SIRT6通过AKT2/AMPK信号通路调控糖尿病性心肌病变的机制研究。10万，已结题，主持。
2. 国家自然科学青年基金，（编号：81500179）：2016年1月—2018年12月，心脏Endo G缺失导致心肌肥大的机制研究。18万，已结题，主持。
3. 江苏省青年基金，（编号：BK201510696）：2015年7月—2018年6月，心肌细胞Endo G缺失导致心肌肥大的分子机制研究。20万，已结题，主持。
4. 江苏省留学回国人员资助项目：2015年1月-2019年12月，心肌细胞EndoG缺失导致心肌肥厚的机制。2万，已结题，主持。
1) Weixian Kong#, Jiawen Chen#, Xinjia Ruan#, Xie Li, Xiaozhi Xu, Mengmeng Bao, Yuru Shao, Xiaohong Bian, Ruiyan Li, Qizhou Jiang, Yubin Zhang, Zhe Li*, Fangrong Yan*, Junmei Ye*. Cardiac Injury Activates STING Signaling via Upregulating SIRT6 in Macrophages After Myocardial Infarction. Life Sciences. (IF=6.1)（2024）
2) Kong W#, Peng Y#, Ji C#, Liu Z, Gao S, Zhang Y, Chen J, Li X, Bao M, Zhang Y, Jiang Q, Wang F, Li Z*, Bian X*, Ye J*. Akt2 deficiency alleviates oxidative stress in the heart and liver via upregulating SIRT6 during high-fat diet-induced obesity. Clin Sci (Lond). 2023 May 15:CS20230433. Clin Sci (Lond). 2023 May 31;137(10):823-841. (IF=6.0). doi: 10.1042/CS20230433.
3) Shuya Gao#, Qingchen Yang#, Yue Peng, Weixian Kong, Zekun Liu, Zhe Li, Jiawen Chen, Mengmeng Bao, Xie Li, Yubin Zhang, Xiaohong Bian, Liang Jin, Hanwen Zhang, Yuexin Zhang, Daniel Sanchis*, Fangrong Yan*, Junmei Ye*. SIRT6 regulates obesity-induced oxidative stress via ENDOG/SOD2 signaling in the heart. Cell Biol Toxicol. . 2023 Aug;39(4):1489-1507.
doi: 10.1007/s10565-022-09735-z. (IF=6.819)
4) Shuya Gao#, Qingchen Yang#, Zekun Liu, Weixian Kong, Jiawen Chen, Xie Li, Yue Peng, Mengmeng Bao, Xiaohong Bian, Yuexin Zhang, Qizhou Jiang, Zhe Li, Yubin Zhang*, Fangrong Yan*, Junmei Ye*. Metformin alleviates HFD-induced oxidative stress in hepatocyte via activating SIRT6/PGC-1α/ENDOG signaling. Clin Sci (Lond). 2022, Nov 30;136(22):1711-1730. (IF=6.0)
doi: 10.1042/CS20220242.
5) Yue Peng, Qingchen Yang, Shuya Gao, Zekun Liu, Weixian Kong, Xiaohong Bian, Zhe Li*, Junmei Ye*. IL-6 protects cardiomyocytes from oxidative stress at the early stage of LPS-induced sepsis. Biochem Biophys Res Commun. 2022 May 7;603:144-152.
doi: 10.1016/j.bbrc.2022.03.013. (IF=3.575)
6) Mengxiao Wang, Bingbing Li, Fujian Qin, Junmei Ye*, Liang Jin*. Obesity induced Ext1 reduction mediates the occurrence of NAFLD. Biochem Biophys Res Commun. 2022 Jan 22;589:123-130.
doi: 10.1016/j.bbrc.2021.12.017. (IF=3.575)
7) Xiaofan Lu#, Caoyu Ji#, Liyun Jiang, Yue Zhu, Yujie Zhou, Jialin Meng, Jun Gao, Tao Lu*, Junmei Ye*, Fangrong Yan*. Tumour microenvironment-based molecular profiling reveals ideal candidates for high-grade serous ovarian cancer immunotherapy. Cell Prolif . 2021 Mar;54(3):e12979.
doi: 10.1111/cpr.12979. （IF=8.755）
8) Miao Chen#, Caoyu Ji#, Qingchen Yang, Shuya Gao, Yue Peng, Zhe Li, Xingyu Gao, Yaoting Li, Nan Jiang, Yubin Zhang, Xiaohong Bian, Caiping Chen, Kaidi Zhang, Daniel Sanchis*, Fangrong Yan*, Junmei Ye*. AKT2 regulates development and metabolic homeostasis via AMPK-dependent pathway in skeletal muscle. Clin Sci (Lond). 2020 Sep 18;134(17):2381-2398.
doi: 10.1042/CS20191320.（IF=6.124）
9) Chen D#, Li Z#, Bao P, Chen M, Zhang M, Yan F, Xu Y, Ji C, Hu X, Sanchis D*, Zhang Y*, Ye J*. Nrf2 deficiency aggravates Angiotensin II-induced cardiac injury by increasing hypertrophy and enhancing IL-6/STAT3-dependent inflammation. Biochim Biophys Acta Mol Basis Dis. 2019 Jun1; 1865(6):1253-1264.
doi: 10.1016/j.bbadis.2019.01.020.（IF=5.108）
10) Shuai Yang#, Dandan Chen#, Fan Chen, Xinmei Zhao, Yubin Zhang, Zhe Li, Liang Jin, Yitao Xu, Daniel Sanchis, Junmei Ye. Deletion of AKT2 preserves cardiac function by blocking IL-6-mediated injury and restores blood pressure during angiotensin II/high salt diet-induced hypertension. J Hypertension. 2018 Apr;36(4): 834-846. doi: 10.1097/HJH.0000000000001613.（IF=4.081）
