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尹骏
职称:副教授
邮箱:junyin@cpu.edu.cn
学院:生命科学与技术学院
实验室:江宁校区学院实验楼一期214室
招生学科:微生物与生化药学,生物与医药
办公室:江宁校区学院实验楼一期213室
个人简历


生物药物成药性研究/聚多肽技术的开发及应用
研究方向


生物药物成药性研究/聚多肽技术的开发及应用
主持在研项目情况

1. 国家自然科学基金青年项目:超电荷聚多肽介导的Cas9蛋白选择性递释及其在治疗非小细胞肺癌中的应用,81703402,主持

2. 中国博士后基金面上资助:聚多肽与Cas9融合蛋白的构建及在肿瘤基因编辑中的应用,2017M611957,主持

3. 中国博士后特别资助项目:新型长效靶向抗耐药肿瘤蛋白DNA药物偶联物的开发,2019T120486,主持

4. 江苏省自然科学基金面上项目:聚多肽融合FGF21蛋白调控肝巨噬细胞Ly6C表型转换在非酒精性脂肪性肝炎相关纤维化中的作用及机制研究,BK20221524,主持

5. 重大新药创制科技重大专项:治疗非酒精性脂肪性肝炎新型生物药PsTag600-FGF21的研发,2019ZX09201001-003-002,参与排二

近年代表性科研成果

1. Haichao Zhu#, Hong Luo#, Ruilong Chang, Yifan Yang, Dingkang Liu, Yue Ji, Hai Qin*, Haibo Rong*, Jun Yin*. Protein-based delivery systems for RNA delivery. Journal of Controlled Release. 2023, 363:253-274.

2. Yue Ji#, Dingkang Liu#, Haichao Zhu, Lichen Bao, Ruilong Chang, Xiangdong Gao*, Jun Yin*. Unstructured Polypeptides as a Versatile Drug Delivery Technology. Acta Biomaterialia. 2023, 164:74-93. 

3. Yifang Yang#, Haichao Zhu#, Dingkang Liu, Hong Luo, Ruilong Chang, Yue Ji, Wenbing Yao*, Jun Yin*, Xiangdong Gao*. A Versatile Platform for the Tumor-Targeted Intracellular Delivery of Peptides, Proteins, and siRNA. Advanced Functional Materials. 2023, 2301011.

4. Dingkang Liu#, Lichen Bao#, Haichao Zhu, Yue Ji, Tian Jing, Xiangdong Gao*, Jun Yin*. Microenvironment-responsive anti-PD-L1 × CD3 bispecific T-cell engager for solid tumor immunotherapy. Journal of Controlled Release. 2023, 354: 606-614.

5. Dingkang Liu#, Ye Chen#, Qun Wang, Yue Ji, Lichen Bao, Wenbing Yao*, Xiangdong Gao*, Jun Yin*. Tailored protein-conjugated DNA nanoplatform for synergistic cancer therapy. Journal of Controlled Release. 2022, 346:250-259.

6. Dingkang Liu#, Haibo Rong#, Ye Chen, Qun Wang, Sijia Qian, Yue Ji, Wenbing Yao*, Jun Yin*, Xiangdong Gao*. Targeted disruption of mitochondria potently reverses multidrug resistance in cancer therapy. British Journal of Pharmacology. 2022, 179(13):3346-3362.

Qun Wang, Yifan Yang, Dingkang Liu, Yue Ji, Xiangdong Gao*, Jun Yin*, Wenbing Yao*.