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张方方
职称:副教授
邮箱:1620194592@cpu.edu.cn
学院:生命科学与技术学院
实验室:江宁校区学院实验楼一期218室
招生学科:微生物与生化药学
办公室:江宁校区学院实验楼一期213室
个人简历

 Fangfang Zhang, Dongshen Ma, Wanli zhao, Danwei Wang, Tingsheng Liu, Yue Liu, Yue Yang, Yuho ng Liu, Jinming Mu, Bingbing Li, Yanfeng Zhang, Yi Pan, Changying Guo, Hong Du, Ling Li, Xianghui Fu*, Zhengyu Cao*, Liang Jin*, Obesity-induced overexpression of miR-802 impairs insulin transcription and secretion. Nature Communications202011(1)1822. (第一作者,2020 IF= 12.121).

 Fangfang Zhang#, Yue Yang#, Xi Chen, Yue Liu, Qianxing Hu, Bin Huang, Yuhong Liu, Yi Pan, Yanfeng Zhang, Dechen Liu, Rui Liang, Guoqing Li, Qiong Wei*, Ling Li*, Liang Jin*, The long non-coding RNA βFaar regulates islet β-cell function and survival during obesity in mice. Nature Communications202112(1)3997. (第一作者,2021 IF:14.919).

 Qianxing Hu#, Jinming Mu#, Yuhong Liu#, Yue Yang, Yue Liu, Yi Pan, Yanfeng Zhang, Ling Li, Dechen Liu, Jianqiu Chen*, Fangfang Zhang*, Liang Jin*, Obesity-induced miR-455 upregulation promotes adaptive pancreatic β-cell proliferation through the CPEB1/CDKN1B pathway. Diabetes202271(3)394-411. (共同通讯作者,2022 IF= 9.460). 

  Yue Liu; Yue Yang; Chenying Xu; Jianxing Liu; Jiale Chen; Guoqing Li; Bin Huang; Yi Pan; Yanfeng Zhang; Qiong Wei; Stephen J. Pandol; Fangfang Zhang*; Ling Li*; Liang Jin*; Circular RNA circGlis3 protects against islet β-cell dysfunction and apoptosis in obesity, Nature Communications, 2023, 14(1): 351. (共同通讯作者,2022 IF=16.6).

 Fangfang Zhang, Yuhong Liu, Danwei Wang, Tingsheng Liu, Yue Yang, Jiamin Guo, Yi Pan, Yanfeng Zhang, Hong Du, Ling Li, Liang Jin*, Obesity-induced reduced expression of lncRNA ROIT impairs insulin transcription by downregulation of Nkx6.1 methylation. Diabetologia, 2020, 63(4): 811-824. (第一作者,2020 IF= 7.518).

研究方向

代谢稳态的靶标挖掘机干预措施

主持在研项目情况

 国家自然科学基金委,面上项目,82370804circPde5a介导线粒体-内质网通讯维持钙稳态改善胰岛β细胞功能的机制研究,2024.01-2027.1249万元。

 国家自然科学基金青年基金,82100858miR-802/TRAF3通路在肥胖诱导的脂肪炎症和胰岛素抵抗中的作用机制研究,2022.01-2024.1230万。

 江苏省青年基金,BK20200569,肥胖降低lncRNA Traf3ip2 as表达介导胰岛β细胞功能损害的机制研究,2020.07-2023.0620万元。

 国家博士后科学基金第15批特别资助(站中),2022T1550726lnc-βFaar/Rab18通过维持脂肪组织脂质稳态改善胰岛素抵抗的作用机制,2022.07-2023.0718万元。

 国家博士后科学基金第67批面上资助,2020M671661miR-802靶向Med13介导胰岛素抵抗的作用机制研究,2020.07-2022.068万元。

 江苏省博士后科研资助1412000016,脂代谢响应型lncRNA Traf3ip2-as改善胰岛β细胞功能的作用机制研究,2020.07-2022.062万元。

近年代表性科研成果

 Fangfang Zhang, Dongshen Ma, Wanli zhao, Danwei Wang, Tingsheng Liu, Yue Liu, Yue Yang, Yuho ng Liu, Jinming Mu, Bingbing Li, Yanfeng Zhang, Yi Pan, Changying Guo, Hong Du, Ling Li, Xianghui Fu*, Zhengyu Cao*, Liang Jin*, Obesity-induced overexpression of miR-802 impairs insulin transcription and secretion. Nature Communications202011(1)1822. (第一作者,2020 IF= 12.121).

 Fangfang Zhang#, Yue Yang#, Xi Chen, Yue Liu, Qianxing Hu, Bin Huang, Yuhong Liu, Yi Pan, Yanfeng Zhang, Dechen Liu, Rui Liang, Guoqing Li, Qiong Wei*, Ling Li*, Liang Jin*, The long non-coding RNA βFaar regulates islet β-cell function and survival during obesity in mice. Nature Communications202112(1)3997. (第一作者,2021 IF:14.919).

 Qianxing Hu#, Jinming Mu#, Yuhong Liu#, Yue Yang, Yue Liu, Yi Pan, Yanfeng Zhang, Ling Li, Dechen Liu, Jianqiu Chen*, Fangfang Zhang*, Liang Jin*, Obesity-induced miR-455 upregulation promotes adaptive pancreatic β-cell proliferation through the CPEB1/CDKN1B pathway. Diabetes202271(3)394-411. (共同通讯作者,2022 IF= 9.460). 

  Yue Liu; Yue Yang; Chenying Xu; Jianxing Liu; Jiale Chen; Guoqing Li; Bin Huang; Yi Pan; Yanfeng Zhang; Qiong Wei; Stephen J. Pandol; Fangfang Zhang*; Ling Li*; Liang Jin*; Circular RNA circGlis3 protects against islet β-cell dysfunction and apoptosis in obesity, Nature Communications, 2023, 14(1): 351. (共同通讯作者,2022 IF=16.6).

 Fangfang Zhang, Yuhong Liu, Danwei Wang, Tingsheng Liu, Yue Yang, Jiamin Guo, Yi Pan, Yanfeng Zhang, Hong Du, Ling Li, Liang Jin*, Obesity-induced reduced expression of lncRNA ROIT impairs insulin transcription by downregulation of Nkx6.1 methylation. Diabetologia, 2020, 63(4): 811-824. (第一作者,2020 IF= 7.518).