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张洁琳
职称:副教授
邮箱:jlzhang@cpu.edu.cn
学院:生命科学与技术学院
实验室:江宁校区学院实验楼一期318室
招生学科:微生物与生化药学,生物与医药
办公室:江宁校区学院实验楼一期315室
个人简历

1. Zhang, J., Grandi E., Fu H., Saravanan T., Bothof L., Tepper P.G., Thunnissen A.-M. W.H. & Poelarends, G.J., “Enantioselective synthesis of chiral synthons for artificial dipeptide sweeteners catalyzed by an engineered C-N lyase”, Angew. Chem. Int. Ed.59, 429-435 (2020).

2. Zhang, J., Fu, H., Tepper, P.G. & Poelarends, G.J., “Biocatalytic enantioselective hydroaminations for production of N-cycloalkyl-substituted L-aspartic acids using two C-N lyases”, Adv. Synth. Catal.361, 2433-2437 (2019).

3. Fu, H.*, Zhang, J.*, Saifuddin, M.*, Cruiming, G., Tepper, P.G. & Poelarends, G.J., “Chemoenzymatic asymmetric synthesis of the metallo-β-lactamase inhibitor aspergillomarasmine A and related aminocarboxylic acids”, Nat. Catal.1, 186-191 (2018).

4. Fu, H., Zhang, J., Tepper, P.G., Bunch, L., Jensen, A. & Poelarends, G.J., “Chemoenzymatic synthesis and pharmacological characterization of functionalized aspartate analogues as novel excitatory amino acid transporter inhibitors”, J. Med. Chem., 61, 7741-7753 (2018).

5. Zhang, J., Tao, S., Zhang, B., Wu, X. & Chen, Y., “A Microparticle-Based Strategy for Controlled Release of Substrate for the Biocatalytic Preparation of L-Homophenylalanine”, ACS Catal.4 1584-1587 (2014). 

研究方向

药物合成生物学,生物催化,酶工程,新酶的发现与酶工程改造,绿色生物制造,多酶级联反应

主持在研项目情况

1. 国家自然科学基金青年项目,820036272021-2023,主持

2. 江苏省自然科学基金青年项目,BK202005652020-2023,主持

近年代表性科研成果

1. Zhang, J., Grandi E., Fu H., Saravanan T., Bothof L., Tepper P.G., Thunnissen A.-M. W.H. & Poelarends, G.J., “Enantioselective synthesis of chiral synthons for artificial dipeptide sweeteners catalyzed by an engineered C-N lyase”, Angew. Chem. Int. Ed.59, 429-435 (2020).

2. Zhang, J., Fu, H., Tepper, P.G. & Poelarends, G.J., “Biocatalytic enantioselective hydroaminations for production of N-cycloalkyl-substituted L-aspartic acids using two C-N lyases”, Adv. Synth. Catal.361, 2433-2437 (2019).

3. Fu, H.*, Zhang, J.*, Saifuddin, M.*, Cruiming, G., Tepper, P.G. & Poelarends, G.J., “Chemoenzymatic asymmetric synthesis of the metallo-β-lactamase inhibitor aspergillomarasmine A and related aminocarboxylic acids”, Nat. Catal.1, 186-191 (2018).

4. Fu, H., Zhang, J., Tepper, P.G., Bunch, L., Jensen, A. & Poelarends, G.J., “Chemoenzymatic synthesis and pharmacological characterization of functionalized aspartate analogues as novel excitatory amino acid transporter inhibitors”, J. Med. Chem., 61, 7741-7753 (2018).

5. Zhang, J., Tao, S., Zhang, B., Wu, X. & Chen, Y., “A Microparticle-Based Strategy for Controlled Release of Substrate for the Biocatalytic Preparation of L-Homophenylalanine”, ACS Catal.4 1584-1587 (2014).