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张雯翔
职称:副教授
邮箱:wenxiangzhang@cpu.edu.cn
学院:生命科学与技术学院
实验室:江宁校区教学楼B207室
招生学科:生物学
办公室:江宁校区教学楼B207室
个人简历


代谢性疾病的分子病理学
研究方向


代谢性疾病的分子病理学
主持在研项目情况

1. 国家重点研发计划青年科学家项目(编号2022YFA0807200),2022.12-2027.11,项目骨干,50万元,在研

2. 国家自然科学基金青年基金项目(编号81800512),2019. 01-2021. 12,主持,21万,已结题;

3. 江苏省自然科学基金青年基金项目(编号BK20180577),2018. 07-2021. 06,主持,20万,已结题;

4. 江苏省博士后科研资助计划, 2017. 09-2018. 10,主持,2万,已结题

近年代表性科研成果

1. Siyu Chen#, Wenxiang Zhang#, Xiao Li, Zhengyu Cao, Chang Liu*. DNA polymerase beta connects tumorigenicity with the circadian clock in liver cancer through the epigenetic demethylation of Per1. Cell Death & Disease (2024), online.

2. Yujie Shi, Yixing Zhou, Yonghong Xiong, Shiyao Zhang, Mingming Song, Xiaofei An, Chang Liu, Wenxiang Zhang*, Siyu Chen*. Host Gasdermin D restrains systemic endotoxemia by capturing Proteobacteria in the colon of high-fat diet-feeding mice. Gut Microbes (2021), 13(1): e1946369.

3. Mingming Song, Chang Liu, Siyu Chen*, Wenxiang Zhang*. Nanocarrier-based drug delivery for melanoma therapeutics. International Journal of Molecular Sciences (2021), 22: 1873.

4. Siyu Chen#, Wenxiang Zhang#, Chen Sun#, Mingming Song#, Shuang Liu, Mengyi Xu, Xiaojing Zhang, Li Liu, Chang Liu*. Systemic nanoparticle-mediated delivery of pantetheinase Vanin-1 regulates lipolysis and adiposity in abdominal white adipose tissue. Advanced Science (2020), 7: 2000542.

5. Wenxiang Zhang#, Zhewen Dong#, Mengyi Xu, Shiyao Zhang, Chang Liu*, Siyu Chen*. SWI/SNF complex subunit BAF60a represses hepatic ureagenesis through a crosstalk between YB-1 and PGC-1α. Molecular Metabolism (2020), 32: 85-96.

6. Wenxiang Zhang, Wei Shao, Zhewen Dong, Shiyao Zhang, Chang Liu*, Siyu Chen*. Cloxiquine, a traditional antituberculosis agent, suppresses the growth and metastasis of melanoma cells through activation of PPARγ. Cell Death & Disease (2019), 10: 404.

7. Wenxiang Zhang#, Peng Wang#, Siyu Chen, Tingming Liang*, Chang Liu*. Rhythmic expression of miR-27 targets the clock gene bmal1 through post-transcriptional regulation in the mouse liver. FASEB Journal (2016), 30: 2151-2560.

8. Siyu Chen#, Wenxiang Zhang#, Chunqi Tang, Xiaoli Tang, Chang Liu*. Vanin-1 is a key activator for the hepatic gluconeogenesis. Diabetes (2014), 63: 2073-2085.