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陈思禹
职称:教授
邮箱:siyuchen@cpu.edu.cn
学院:生命科学与技术学院
实验室:江宁校区教学楼B207室
招生学科:生物学,微生物与生化药学
办公室:江宁校区教学楼B207室
个人简历

1. Chen S$, Zhang W$, Sun C$, Song M$, Liu S, Xu M, Zhang X, Liu L & Liu C*. (2020). Systemic Nanoparticle-Mediated Delivery of Pantetheinase Vanin-1 Regulates Lipolysis and Adiposity in Abdominal White Adipose Tissue. Advanced Science, 7(14): 2000542.【一区,IF=15.84

2. Song M, Zhang S, Tao Z, Li J, Shi Y, Xiong Y, Zhang W, Liu C & Chen S*. (2021). MMP-12 siRNA improves the homeostasis of the small intestine and metabolic dysfunction in high-fat diet feeding-induced obese mice. Biomaterials, 278: 121183.【一区,IF=12.479

3. Chen S$, Feng M$, Zhang S, Dong Z, Wang Y, Zhang W & Liu C*. (2019). Angptl8 mediates food-driven resetting of hepatic circadian clock in mice. Nature Communications, 10(1): 1-16.【一区,IF=11.878

4. Shi Y$, Zou Y$, Xiong Y$, Zhang S$, An X, Liu C, Zhang W* & Chen S*. (2021). Host Gasdermin D restrains systemic endotoxemia by capturing Proteobacteria in the colon of high-fat diet-feeding mice. Gut Microbes, 13(1): 1946369.【一区,IF=10.245

5. Song M$, Dong S$, An X, Zhang W, Shen N, Li Y, Guo C, Liu C, Li X* & Chen S*. (2022). Erythrocyte-biomimetic nanosystems to improve antitumor effects of paclitaxel on epithelial cancers. Journal of Controlled Release, 345: 744-754.【一区,IF=11.467

6. Chen S$, Zhang W$, Li X, Cao Z, Liu C*. (2024). DNA polymerase beta connects tumorigenicity with the circadian clock in liver cancer through the epigenetic demethylation of Per1. Cell Death & Disease, 15(1): 78.【一区,IF=9.0

7. Zhang W$, Dong Z$, Xu M, Zhang S, Liu C* & Chen S*. (2020). SWI/SNF complex subunit BAF60a represses hepatic ureagenesis through a crosstalk between YB-1 and PGC-1α. Molecular Metabolism, 32, 85–96. 【一区,IF=8.1

8. Song M, Xia W, Tao Z, Zhu B, Zhang W, Liu C* & Chen S*. (2021). Self-assembled polymeric nanocarrier-mediated co-delivery of metformin and doxorubicin for melanoma therapy. Drug Delivery, 28(1), 594–606. 【二区,IF=6

9. Zhang W, Shao W, Dong Z, Zhang S, Liu C* & Chen S*. (2019). Cloxiquine, a traditional antituberculosis agent, suppresses the growth and metastasis of melanoma cells through activation of PPARγ. Cell Death & Disease, 10(6), 404.【一区,IF=9

Chen S$, Li X$, Liu L, Liu C* & Han X*. (2018). Ophiopogonin D alleviates high-fat diet-induced metabolic syndrome and changes the structure of gut microbiota in mice. FASEB Journal, 32(3), 1139–1153.【二区,IF=4.8

研究方向


代谢性疾病的靶标发现和干预策略研究
主持在研项目情况

1. 主持国家重点研发计划青年科学家项目(编号2022YFA08070200),400万,2022.12-2027.11

2. 主持江苏省自然科学基金优秀青年基金(编号BK20220151),50万,2022.07-2025.06

3. 主持国家自然科学基金青年基金项目(编号31800992),26万,2019. 01-2021.12

4. 主持江苏省自然科学基金青年基金项目(编号BK20180554),20万,2018.07-2021.06

5. 主持中国药科大学高层次人才引进启动经费,100万,2018.01-2023.11

6. 主持中国药科大学生命科学与技术学院青年教师发展促进项目,10万,2020.07-2021.12

7. 主持中国药科大学中央基本业务费项目,8万,2018.01-2019.12

近年代表性科研成果

1. Chen S$, Zhang W$, Sun C$, Song M$, Liu S, Xu M, Zhang X, Liu L & Liu C*. (2020). Systemic Nanoparticle-Mediated Delivery of Pantetheinase Vanin-1 Regulates Lipolysis and Adiposity in Abdominal White Adipose Tissue. Advanced Science, 7(14): 2000542.【一区,IF=15.84

2. Song M, Zhang S, Tao Z, Li J, Shi Y, Xiong Y, Zhang W, Liu C & Chen S*. (2021). MMP-12 siRNA improves the homeostasis of the small intestine and metabolic dysfunction in high-fat diet feeding-induced obese mice. Biomaterials, 278: 121183.【一区,IF=12.479

3. Chen S$, Feng M$, Zhang S, Dong Z, Wang Y, Zhang W & Liu C*. (2019). Angptl8 mediates food-driven resetting of hepatic circadian clock in mice. Nature Communications, 10(1): 1-16.【一区,IF=11.878

4. Shi Y$, Zou Y$, Xiong Y$, Zhang S$, An X, Liu C, Zhang W* & Chen S*. (2021). Host Gasdermin D restrains systemic endotoxemia by capturing Proteobacteria in the colon of high-fat diet-feeding mice. Gut Microbes, 13(1): 1946369.【一区,IF=10.245

5. Song M$, Dong S$, An X, Zhang W, Shen N, Li Y, Guo C, Liu C, Li X* & Chen S*. (2022). Erythrocyte-biomimetic nanosystems to improve antitumor effects of paclitaxel on epithelial cancers. Journal of Controlled Release, 345: 744-754.【一区,IF=11.467

6. Chen S$, Zhang W$, Li X, Cao Z, Liu C*. (2024). DNA polymerase beta connects tumorigenicity with the circadian clock in liver cancer through the epigenetic demethylation of Per1. Cell Death & Disease, 15(1): 78.【一区,IF=9.0

7. Zhang W$, Dong Z$, Xu M, Zhang S, Liu C* & Chen S*. (2020). SWI/SNF complex subunit BAF60a represses hepatic ureagenesis through a crosstalk between YB-1 and PGC-1α. Molecular Metabolism, 32, 85–96. 【一区,IF=8.1

8. Song M, Xia W, Tao Z, Zhu B, Zhang W, Liu C* & Chen S*. (2021). Self-assembled polymeric nanocarrier-mediated co-delivery of metformin and doxorubicin for melanoma therapy. Drug Delivery, 28(1), 594–606. 【二区,IF=6

9. Zhang W, Shao W, Dong Z, Zhang S, Liu C* & Chen S*. (2019). Cloxiquine, a traditional antituberculosis agent, suppresses the growth and metastasis of melanoma cells through activation of PPARγ. Cell Death & Disease, 10(6), 404.【一区,IF=9

Chen S$, Li X$, Liu L, Liu C* & Han X*. (2018). Ophiopogonin D alleviates high-fat diet-induced metabolic syndrome and changes the structure of gut microbiota in mice. FASEB Journal, 32(3), 1139–1153.【二区,IF=4.8