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丁明
职称:教授
邮箱:mingding@cpu.edu.cn
学院:生命科学与技术学院
实验室:江宁校区实验楼G256室
招生学科:生物学,生物与医药
办公室:江宁校区实验楼G256室
个人简历

Proteomics analysis uncovers plasminogen activator PLAU as a target of the STING pathway for suppression of cancer cell migration and invasion.Tan J, Ge Y, Zhang M, Ding M*.J Biol Chem. 2023 Jan;299(1):102779.

TXLNA enhances TBK1 phosphorylation by suppressing PPM1B recruitment.Tian X, Zhang Z, Ding M*. Biochim Biophys Acta Mol Cell Res. 2023 Oct;1870(7):119550.

Integrated proteomics and phosphoproteomics profiling reveals the cardioprotective mechanism of bioactive compounds derived from Salvia miltiorrhiza Burge.Duan S, Zhang M, Zeng H, Song J, Zhang M, Gao S, Yang H, Ding M*, Li P*.Phytomedicine. 2023 Aug;117:154897.

Secreted IGFBP5 mediates mTORC1-dependent feedback inhibition of IGF-1 signalling. Ding M, Bruick RK, Yu Y. Nat Cell Biol. 2016 ar;18(3):319-27

研究方向


细胞信号通路调控机制及新颖靶向治疗方法
主持在研项目情况

科技部重点研发项目子课题,强活性药效物质的靶标发现及作用机制研究

国家自然科学基金面上项目,FICD蛋白通过催化腺苷化翻译后修饰调控肺鳞癌的机制

研究

近年代表性科研成果

Proteomics analysis uncovers plasminogen activator PLAU as a target of the STING pathway for suppression of cancer cell migration and invasion.Tan J, Ge Y, Zhang M, Ding M*.J Biol Chem. 2023 Jan;299(1):102779.

TXLNA enhances TBK1 phosphorylation by suppressing PPM1B recruitment.Tian X, Zhang Z, Ding M*. Biochim Biophys Acta Mol Cell Res. 2023 Oct;1870(7):119550.

Integrated proteomics and phosphoproteomics profiling reveals the cardioprotective mechanism of bioactive compounds derived from Salvia miltiorrhiza Burge.Duan S, Zhang M, Zeng H, Song J, Zhang M, Gao S, Yang H, Ding M*, Li P*.Phytomedicine. 2023 Aug;117:154897.

Secreted IGFBP5 mediates mTORC1-dependent feedback inhibition of IGF-1 signalling. Ding M, Bruick RK, Yu Y. Nat Cell Biol. 2016 ar;18(3):319-27