关闭
窦洁
职称:教授
邮箱:doujie@cpu.edu.cn
学院:生命科学与技术学院
实验室:江宁校区学院实验楼一期317室
招生学科:微生物与生化药学
办公室:江宁校区学院实验楼一期313室
个人简历

窦洁女,教授,博,汉族。1997年就职于中国药科大学生命科学与技术学院至今。期间,2013年-2014年,赴美国圣路易斯大学访问;2019年-2020年,任职西藏藏医药大学藏药系。主要社会工作:江苏省微生物学会理事,江苏省免疫学会理事,南京预防医学会病毒与免疫专委会成员。

主要科研领域为抗病毒与抗肿瘤细胞学与免疫学机制研究病毒感染肺纤维化研究、mRNA疫苗研发。至今在国内外核心期刊上发表学术论文余篇,其中SCI 论文40余篇,授权发明专利15项。


研究方向


抗病毒抗肿瘤药物的生物学机制免疫机制研究


主持在研项目情况

l 黄芩苷诱导肿瘤细胞老化参与大肠癌治疗新机制研究,国家自然科学基金面上项目

l 新型注射用聚山梨酯80产业化技术研究

l 芬地柞酸左旋氯哌丁混悬液微生物限度检查方法学研究

l 雷氟唑康抗口腔白色念珠菌体外药效学研究

近年代表性科研成果

l Wang Mengru., Tian Baopeng., Shen Jie., Xu Shilin., Liu Cong., Guan Ling., Guo Min., Dou Jie*.(2023). Bavachin induces apoptosis in colorectal cancer cells through Gadd45a via the MAPK signaling pathway. Chin J Nat Med, 21(1), 36-46. doi:10.1016/S1875-5364(23)60383-8

l Zhang Xue., Su Huiling., Yu Haifei., Ding Jialu., Deng Wanyu., Qin Bo., Zhou Changlin., Dou Jie*, Guo Min.(2022). Eupolyphaga sinensisA Polysaccharide From  Walker With Anti-HBV Activities  and . Front Pharmacol, 13(undefined), 827128. doi:10.3389/fphar.2022.827128

l Guo Min., Ni Jiawei., Yu Jie., Jin Jing., Ma Lingman., Zhang Huixing., Wang Dechuan., Zhang Xue., Dou Jie*, Zhou Changlin.(2019). Antiviral Activity of Benzoic Acid Derivative NC-5 Against Influenza A Virus and Its Neuraminidase Inhibition. Int J Mol Sci, 20(24), undefined. doi:10.3390/ijms20246261

l Xu Jun., Chen Shuo., Jin Jing., Ma Lingman., Guo Min., Zhou Changlin., Dou Jie*.(2019). Inhibition of peptide BF-30 on influenza A virus infection in vitro/vivo by causing virion membrane fusion. Peptides, 112(undefined), 14-22. doi:10.1016/j.peptides.2018.10.004

l Su Meng-Qi., Zhou Yi-Ran., Rao Xuan., Yang Hong., Zhuang Xin-Hao., Ke Xue-Jia., Peng Guang-Yong., Zhou Chang-Lin., Shen Bai-Yong., Dou Jie*.(2018). Baicalein induces the apoptosis of HCT116 human colon cancer cells via the upregulation of DEPP/Gadd45a and activation of MAPKs. Int J Oncol, 53(2), 750-760. doi:10.3892/ijo.2018.4402

l Dou Jie*, Wang Zhou., Ma Leon., Peng Bo., Mao Ke., Li Chengqin., Su Mengqi., Zhou Changlin., Peng Guangyong.(2018). Baicalein and baicalin inhibit colon cancer using two distinct fashions of apoptosis and senescence. Oncotarget, 9(28), 20089-20102. doi:10.18632/oncotarget.24015

l Jin Jing., Chen Yuanjin., Wang Dechuan., Ma Lingman., Guo Min., Zhou Changlin., Dou Jie*.(2018). The inhibitory effect of sodium baicalin on oseltamivir-resistant influenza A virus via reduction of neuraminidase activity. Arch Pharm Res, 41(6), 664-676. doi:10.1007/s12272-018-1022-6

l Wang Zhou., Ma Lingman., Su Mengqi., Zhou Yiran., Mao Ke., Li Chengqin., Peng Guangyong., Zhou Changlin., Shen Baiyong., Dou Jie*.(2018). Baicalin induces cellular senescence in human colon cancer cells via upregulation of DEPP and the activation of Ras/Raf/MEK/ERK signaling. Cell Death Dis, 9(2), 217. doi:10.1038/s41419-017-0223-0

l Jin Jing., Chen Shuo., Wang Dechuan., Chen Yuanjin., Wang Yuxu., Guo Min., Zhou Changlin., Dou Jie*(2018). Oroxylin A suppresses influenza A virus replication correlating with neuraminidase inhibition and induction of IFNs. Biomed Pharmacother, 97(undefined), 385-394. doi:10.1016/j.biopha.2017.10.140

l Kang Wei., Liu Hanhan., Ma Lingman., Wang Mengxiao., Wei Shanshan., Sun Pengbo., Jiang Meiling., Guo Min., Zhou Changlin., Dou Jie*.(2017). Effective antimicrobial activity of a peptide mutant Cbf-14-2 against penicillin-resistant bacteria based on its unnatural amino acids. Eur J Pharm Sci, 105(undefined), 169-177. doi:10.1016/j.ejps.2017.05.030