(1)器官衰老及其病变的分子机理；

(2)靶向细胞衰老维持器官功能稳态的策略研究。

科技部重点研发项目，2022YFC2303200，课题负责人

国家自然科学基金-面上项目，主持

科技部重点研发项目，2023YFA1801900，骨干

国家自然科学基金-优秀青年科学基金项目，主持

国家自然科学基金-重大研究计划培育项目，主持

国家自然科学基金-面上项目，主持

江苏省双创团队（核心）

1. Peng L#, Xiang S#, Wang T, Yang M, Duan Y, Ma X, Li S, Yu C, Zhang X, Hu H, Liu Z, Sun J, Sun C, Wang C, Liu B*, Wang Z*, Qian M*. The hepatic clock orchestrates with HIF-1a to coordinate nucleotide availability during liver damage repair. Nature Metabolism. 2024 (In press)

2. Wang K#, Zhang X#, Fan Y, Zhou L, Duan Y, Li S, Sun Z, Zhang C, Yang H, Yuan W, Peng L, Ma X, Xiang S, Wang T, Yang M, Zhang Z, Wang J, Wang Z*, Qian M*. Reactivation of MAPK-SOX2 pathway confers ferroptosis sensitivity in KRASG12C inhibitor resistant tumors. Redox Biology. 2024 Nov 5;78:103419.

3. Zhang X#, Duan Y#, Li S, Zhang Z, Peng L, Ma X, Wang T, Xiang S, Chen G, Zhou D, Lu D*, Qian M*, Wang Z*. CRISPR screening identifies PRMT1 as a key pro-ferroptotic gene via a two-layer regulatory mechanism. Cell Reports. 2024 Sep 24;43(9):114662.

4. Peng L#, Zhou L#, Li H, Zhang X, Li S, Wang K, Yang M, Ma X, Zhang D, Xiang S, Duan Y, Wang T, Sun C, Wang C, Lu D*, Qian M*, Wang Z*. Hippo signaling-controlled MHC-I antigen processing and presentation pathway potentiates antitumor immunity. Cell Reports. 2024 Apr 23;43(4):114003.

5. Peng L#, Qian M#*, Liu Z, Tang X, Sun J, Jiang Y, Sun S, Cao X, Pang Q, Liu B*. Deacetylase-independent function of SIRT6 couples GATA4 transcription factor and epigenetic activation against cardiomyocyte apoptosis. Nucleic Acids Research. 2020, May 21;48(9):4992-5005. 

6. Meng F#, Qian M#, Peng B#, Wang X, Peng L, Zheng K, Liu Z, Tang X, Zhang S, Sun S, Cao X, Pang Q, Zhao B, Ma W, Songyang Z, Xu B, Zhu WG, Xu X*, Liu B*. Synergy between SIRT1 and SIRT6 helps recognize DNA breaks and potentiate the DNA damage response and repair. eLife. 2020, Jun 15;9:e55828.  

7. Liu Z#,Qian M#, Tang X, Hu W, Sun S, Li G, Zhang S, Meng F, Cao X, Sun J, Xu C, Tan B, Pang Q, Zhao B, Wang Z, Guan Y, Ruan X, Liu B.* SIRT7 couples light-driven body temperature cues to hepatic circadian phase coherence and gluconeogenesis. Nature Metabolism. 2019 1, 1141–1156. 

8. Qian M, Liu B*. Pharmaceutical Intervention of Aging. Adv Exp Med Biol. 2018; 1086:235-254.  

9. Qian M#, Liu Z#, Peng L, Tang X, Meng F, Ao Y, Zhou M, Wang M, Cao X, Qin B, Wang Z, Zhou Z, Wang G, Gao Z, Xu J, Liu B*. Boosting ATM Activity alleviates ageing and extends lifespan in a mouse model of progeria. eLife. 2018 May 2; 7:e34836.  

10. Qian M#, Pang Y#, Liu CH#, Haratake K#, Du BY#, Ji DY, Wang GF, Zhu QQ, Song W, Yu Y, Zhang XX, Chen LB, Zhang ZH, et al, Wang L, Goldberg AL, Shen Y, Qiu XB*. Acetylation-Mediated Proteasomal Degradation of Core Histones during DNA Repair and Spermatogenesis. Cell. 2013 May, 153, 1012–1024.