衰老分子机制及老年相关疾病研究

中国药科大学高层次人才科研启动基金

科技部重点研发计划—2022YFC2303200，2022.12至2024.12，490万，课题负责人

国家自然科学基金-面上项目（82271602），2023.01-2026.12，52万，主持

国家自然科学基金-优秀青年科学基金项目（82022025），2021.01至2023.12，150万，主持

国家自然科学基金-重大研究计划培育项目（91949124），2020.01-2022.12，81万，结题

国家自然科学基金-面上项目（81871114），2019.01-2022.12，56万，结题

1、Meng F#, Qian M#, Peng B#, Wang X, Peng L, Zheng K, Liu Z, Tang X, Zhang S, Sun S, Cao X, Pang Q, Zhao B, Ma W, Songyang Z, Xu B, Zhu WG, Xu X*, Liu B*. Synergy between SIRT1 and SIRT6 helps recognize DNA breaks and potentiate the DNA damage response and repair. eLife. 2020, Jun 15;9:e55828.   

2、Peng L#, Qian M#*, Liu Z, Tang X, Sun J, Jiang Y, Sun S, Cao X, Pang Q, Liu B*. Deacetylase-independent function of SIRT6 couples GATA4 transcription factor and epigenetic activation against cardiomyocyte apoptosis. Nucleic Acids Research. 2020, May 21;48(9):4992-5005.  

3、Liu Z#, Qian M#, Tang X, Hu W, Sun S, Li G, Zhang S, Meng F, Cao X, Sun J, Xu C, Tan B, Pang Q, Zhao B, Wang Z, Guan Y, Ruan X, Liu B.* SIRT7 couples light-driven body temperature cues to hepatic circadian phase coherence and gluconeogenesis. Nature Metabolism. 2019 1, 1141–1156.  

4、Qian M, Liu B*. Pharmaceutical Intervention of Aging. Adv Exp Med Biol. 2018; 1086:235-254.   

5、Qian M#, Liu Z#, Peng L, Tang X, Meng F, Ao Y, Zhou M, Wang M, Cao X, Qin B, Wang Z, Zhou Z, Wang G, Gao Z, Xu J, Liu B*. Boosting ATM Activity alleviates ageing and extends lifespan in a mouse model of progeria. eLife. 2018 May 2; 7:e34836.   

6、Qian M#, Pang Y#, Liu CH#, Haratake K#, Du BY#, Ji DY, Wang GF, Zhu QQ, Song W, Yu Y, Zhang XX, Chen LB, Zhang ZH, et al, Wang L, Goldberg AL, Shen Y, Qiu XB*. Acetylation-Mediated Proteasomal Degradation of Core Histones during DNA Repair and Spermatogenesis. Cell. 2013 May, 153, 1012–1024.