1、教育经历
(1) 2016-09 至 2021-06, 南京大学, 生物学, 博士
(2) 2013-09 至 2016-06, 南京医科大学, 遗传学, 硕士
(3) 2009-09 至 2013-06, 宁夏医科大学, 生物技术, 学士
2、工作经历
(1) 2021-07 至 今, 在站, 中国药科大学
3、学术荣誉
4、学术兼职
1、肿瘤免疫机制及靶向肿瘤的特异性T细胞研究
1. 中国博士后科学基金, 第70批面上资助, 1602100015, 可变多聚腺苷酸化调控外泌体介导的CD47蛋白选择性分泌机制研究, 2021-09 至 今, 8万元, 在研, 主持
1. Shuang Qu*, Zichen Jiao*, Geng Lu*, Bing Yao, Ting Wang, Weiwei Rong, Jiahan Xu, Ting Fan , Xinlei Sun, Rong Yang , Jun Wang, Yongzhong Yao, Guifang Xu, Xin Yan, Tao Wang#, Hongwei Liang#, Ke Zen#. PD-L1 lncRNA splice isoform promotes lung adenocarcinoma progression via enhancing c-Myc activity. Genome Biol (IF: 13.2). 2021 Apr 13;22(1):104. doi: 10.1186/s13059-021-02331-0. PMID: 33849634; PMCID: PMC8042710.
2. Xiaodong Xu*, Shuang Qu*, Changming Zhang , Mingchao Zhang , Weisong Qin , Guisheng Ren , Hao Bao, Limin Li, Ke Zen#, Zhihong Liu#. CD8 T Cell-Derived Exosomal miR-186-5p Elicits Renal Inflammation via Activating Tubular TLR7/8 Signal Axis. Adv Sci (IF: 15.1). 2023 Sep;10(25):e2301492. doi: 10.1002/advs.202301492. Epub 2023 Jul 3. PMID: 37395441; PMCID: PMC10477851.
3. Yujie Zhu* , Mingchao Zhang* , Weiran Wang*, Shuang Qu*, Minghui Liu , Weiwei Rong , Wenwen Yang , Hongwei Liang , Caihong Zeng , Xiaodong Zhu , Limin Li , Zhihong Liu# , Ke Zen#. Polynucleotide phosphorylase protects against renal tubular injury via blocking mt-dsRNA-PKR-eIF2α axis. Nat Commun (IF: 16.6). 2023 Mar 3;14(1):1223. doi: 10.1038/s41467-023-36664-0. PMID: 36869030; PMCID: PMC9984537.
4. Zhou Yang*, Wei Su* , Xiyi Wei* , Shuang Qu* , Dan Zhao , Jingwan Zhou , Yunjun Wang , Qing Guan , Chao Qin# , Jun Xiang# , Ke Zen# , Bing Yao# . HIF-1α drives resistance to ferroptosis in solid tumors by promoting lactate production and activating SLC1A1. Cell Rep (IF:9.995). 2023 Aug 29;42(8):112945. doi: 10.1016/j.celrep.2023.112945. Epub 2023 Aug 4. PMID: 37542723.
5. Shuang Qu*, Zichen Jiao*, Geng Lu*, Jiahan Xu , Bing Yao , Ting Wang , Jun Wang , Yongzhong Yao , Xin Yan , Tao Wang# , Hongwei Liang# , Ke Zen# . Human lung adenocarcinoma CD47 is upregulated by interferon-γ and promotes tumor metastasis. Mol Ther Oncolytics (IF: 6.3). 2022 May 3;25:276-287. doi: 10.1016/j.omto.2022.04.011. PMID: 35663227; PMCID: PMC9127120.
6. Shuang Qu*, Jiahui Wu , Qianyi Bao , Bing Yao, Rui Duan , Xiang Chen , Lingyun Li , Hongyan Yuan , Yucui Jin , Changyan Ma#. Osterix promotes the migration and angiogenesis of breast cancer by upregulation of S100A4 expression. J Cell Mol Med (IF: 5.3). 2019 Feb;23(2):1116-1127. doi: 10.1111/jcmm.14012. Epub 2018 Nov 18. PMID: 30450809; PMCID: PMC6349213.4.
7. Tingting Zhao*, Dongdong Zhan*, Shuang Qu*, Song Jiang, Wenhua Gan, Weisong Qin, Chunxia Zheng , Fang Cheng , Yinghui Lu , Mingwei Liu , Jinsong Shi , Hongwei Liang , Yi Wang , Jun Qin , Ke Zen# , Zhihong Liu#. Transcriptomics-proteomics Integration reveals alternative polyadenylation driving inflammation-related protein translation in patients with diabetic nephropathy. J Transl Med (IF: 8.44). 2023 Feb 6;21(1):86. doi: 10.1186/s12967-023-03934-w. PMID: 36747266; PMCID: PMC9900993.
8. Nan Wang*, Shuang Qu*, Wu Sun*, Ziyi Zeng, Hongwei Liang , Chen-Yu Zhang , Xi Chen , Ke Zen# . Direct quantification of 3' terminal 2'-O-methylation of small RNAs by RT-qPCR. RNA (IF: 4.5). 2018 Nov;24(11):1520-1529. doi: 10.1261/rna.065144.117. Epub 2018 Aug 3. PMID: 30076204; PMCID: PMC6191718.
