1、蛋白质降解在肿瘤发生发展的作用及分子机理

2、基于蛋白质降解的抗肿瘤药物的开发与应用

1)Zhang M†, Dai Z, Zhao X, Wang G, Lai R*. Anticarin β Inhibits Human Glioma Progression by Suppressing Cancer Stemness via STAT3. Front Oncol. 2021;11:715673. 2021 Aug 2. doi:10.3389/fonc.2021.715673

2)Wang G†, Zhang M†, Meng P†, Long C†, Luo X†, Yang X, Wang Y, Zhang Z, Mwangi J, Kamau PM, Dai Z, Ke Z, Zhang Y, Chen W, Zhao X, Gei F, Lv Q, Rong M, Li D, Jin Y*, Sheng X*, Lai R*. Anticarin-β shows a promising anti-osteosarcoma effect by specifically inhibiting CCT4 to impair proteostasis. Acta Pharm Sin B. 2022 May;12(5):2268-2279. doi: 10.1016/j.apsb.2021.12.024.

3)Zheng F†, Zhang M†, Yang X, Wu F, Wang G, Feng X, Ombati R, Zuo R, Yang C, Liu J, Lai R*, Luo X*, Long C*. Prostaglandin E1 Is an Efficient Molecular Tool for Forest Leech Blood Sucking. Front Vet Sci. 2021 Jan 7;7:615915. doi: 10.3389/fvets.2020.615915.