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李赫羽
职称:教授
邮箱:heyuli@cpu.edu.cn
学院:生命科学与技术学院
实验室:江宁校区学院实验楼二期323室
招生学科:生物学、微生物与生化药学
办公室:江宁校区学院实验楼二期310室
个人简历

Li H, Liu C, Li R, Zhou L, Ran Y, Yang Q, Huang H, Lu H, Song H, Yang B,  Ru H, Lin S, Zhang L*. AARS1 and AARS2 Sense L-lactate to regulate cGAS as global lysine lactyltransferase. Nature. (IF=50.5) (2024 Oct;634(8036):1229-1237) 

Li H, Zhou F*, Zhang L*. STING, a critical contributor to SARS-CoV-2 immunopathology. Signal Transduct Target Ther. (IF=39.3) (2022 Mar 30;7(1):106)

Li H, Zhou F*, Zhang L*. ADP-riboxanation: a new pyroptosis evasion strategy. J Mol Cell Biol. (IF=8.2) (2022 Mar 21;14(1):mjab077)

Xie F#, Zhou X#, Li H, Su P, Liu S, Li R, Zou J, Wei X, Pan C, Zhang Z, Zheng M, Liu Z, Meng X, Ovaa H, Ten Dijke P*, Zhou F*, Zhang L*. USP8 promotes cancer progression and extracellular vesicle-mediated CD8+ T cell exhaustion by deubiquitinating the TGF-β receptor TβRII. EMBO J. (IF=9.4) (2022 Aug 16;41(16):e108791)

Xie F#, Zhou X#, Su P, Li H, Tu Y, Du J, Pan C, Wei X, Zheng M, Jin K, Miao L, Wang C, Meng X, van Dam H, Ten Dijke P, Zhang L*, Zhou F*. Breast cancer cell-derived extracellular vesicles promote CD8+ T cell exhaustion via TGF-β type II receptor signaling. Nat Commun. (IF=14.7) (2022 Aug 1;13(1):4461)

Xie F#, Su P#, Pan T#, Zhou X, Li H, Huang H, Wang A, Wang F, Huang J, Yan H, Zeng L, Zhang L*, Zhou F*. Engineering Extracellular Vesicles Enriched with Palmitoylated ACE2 as COVID-19 Therapy. Adv Mater. (IF=29.4) (2021 Dec;33(49):e2103471)

Yang Q, Wang B, Zheng Q, Li H, Meng X*, Zhou F*, Zhang L*. A Review of Gut Microbiota-Derived Metabolites in Tumor Progression and Cancer Therapy. Adv Sci (Weinh). (IF=15.1) (2023 May;10(15):e2207366)

 Xie F, Zhou X, Fang M, Li H, Su P, Tu Y, Zhang L, Zhou F*. Extracellular Vesicles in Cancer Immune Microenvironment and Cancer Immunotherapy. Adv Sci (Weinh). (IF=15.1) (2019 Oct 23;6(24):1901779) 


研究方向

代谢与蛋白质动态调控


主持在研项目情况


近年代表性科研成果

Li H, Liu C, Li R, Zhou L, Ran Y, Yang Q, Huang H, Lu H, Song H, Yang B,  Ru H, Lin S, Zhang L*. AARS1 and AARS2 Sense L-lactate to regulate cGAS as global lysine lactyltransferase. Nature. (IF=50.5) (2024 Oct;634(8036):1229-1237) 

Li H, Zhou F*, Zhang L*. STING, a critical contributor to SARS-CoV-2 immunopathology. Signal Transduct Target Ther. (IF=39.3) (2022 Mar 30;7(1):106)

Li H, Zhou F*, Zhang L*. ADP-riboxanation: a new pyroptosis evasion strategy. J Mol Cell Biol. (IF=8.2) (2022 Mar 21;14(1):mjab077)

Xie F#, Zhou X#, Li H, Su P, Liu S, Li R, Zou J, Wei X, Pan C, Zhang Z, Zheng M, Liu Z, Meng X, Ovaa H, Ten Dijke P*, Zhou F*, Zhang L*. USP8 promotes cancer progression and extracellular vesicle-mediated CD8+ T cell exhaustion by deubiquitinating the TGF-β receptor TβRII. EMBO J. (IF=9.4) (2022 Aug 16;41(16):e108791)

Xie F#, Zhou X#, Su P, Li H, Tu Y, Du J, Pan C, Wei X, Zheng M, Jin K, Miao L, Wang C, Meng X, van Dam H, Ten Dijke P, Zhang L*, Zhou F*. Breast cancer cell-derived extracellular vesicles promote CD8+ T cell exhaustion via TGF-β type II receptor signaling. Nat Commun. (IF=14.7) (2022 Aug 1;13(1):4461)

Xie F#, Su P#, Pan T#, Zhou X, Li H, Huang H, Wang A, Wang F, Huang J, Yan H, Zeng L, Zhang L*, Zhou F*. Engineering Extracellular Vesicles Enriched with Palmitoylated ACE2 as COVID-19 Therapy. Adv Mater. (IF=29.4) (2021 Dec;33(49):e2103471)

Yang Q, Wang B, Zheng Q, Li H, Meng X*, Zhou F*, Zhang L*. A Review of Gut Microbiota-Derived Metabolites in Tumor Progression and Cancer Therapy. Adv Sci (Weinh). (IF=15.1) (2023 May;10(15):e2207366)

 Xie F, Zhou X, Fang M, Li H, Su P, Tu Y, Zhang L, Zhou F*. Extracellular Vesicles in Cancer Immune Microenvironment and Cancer Immunotherapy. Adv Sci (Weinh). (IF=15.1) (2019 Oct 23;6(24):1901779)