余海翔，教授，博士生导师。佛罗里达国际大学博士，杜克大学医学中心博士后。国家级高层次青年人才计划入选者。主要研究领域为功能化核酸适配体的定向进化和应用。在利用适配体技术进行毒品等小分子靶标现场快检、构建适配体酶抑制剂类核酸药物等方向取得突出进展。近年来在Nat. Commun.、Nucleic Acid Res.、Angew. Chem. Int. Ed.、J. Am. Chem. Soc. 等国际权威期刊发表科研论文37篇，被引用超过1700次，其中第一/通讯作者（含共同）13篇。申请发明专利10项，获授权9项。现主持江苏省自然科学基金一项。
功能适配体定向进化策略
适配体生物传感器
适配体药物开发
2024 中国药科大学兴药领军学者引进计划
2022024年江苏省自然科学基金青年基金项目 (BK20241586) 4 中国药科大学兴药领军学者引进计划
Yu H., Canoura J., Byrd C., Alkhamis O., Bacon A., Yan A., Sullenger B. A. & Xiao Y. (2025) Improving Aptamer Affinity and Determining Sequence–Activity Relationships via Motif-SELEX. J. Am. Chem. Soc. 147, 9472–9486. (期刊论文)
Yu H., Kumar S., Frederiksen J.W., Kolyadko V.N., Pitoc G., Layzer J., Yan A., Rempel R., Francis S., Krishnaswamy S. & Sullenger B.A. (2024) Aptameric hirudins as selective and reversible EXosite-ACTive site (EXACT) inhibitors. Nat. Commun. 15, 3977. (期刊论文)
Yu H. （共一）, Alkhamis O., Canoura J., Liu Y., & Xiao Y. (2021) Advances and challenges in small‐molecule DNA aptamer isolation, characterization, and sensor development. Angew. Chem., Int. Ed., 60, 16800 – 16823. (期刊论文)
Yu H., Chen, Z., Liu Y., Alkhamis O., Song Z., & Xiao Y. (2021) Fabrication of aptamer-modified paper electrochemical devices for on-site biosensing. Angew. Chem., Int. Ed., 133, 3030 – 3037. (期刊论文)
Yu H., Luo Y., Alkhamis O., Canoura J., & Xiao Y. (2021) Isolation of natural DNA aptamers for challenging small-molecule targets, cannabinoids. Anal. Chem. 93, 3172 – 3180.
Xiao Y., Alkhamis O. & Yu H. DNA Aptamer-Cyanine Complexes as Generic Colorimetric Sensors, 2021-08-07, 美国, 17/396,663 (专利)
Yang W., Yu H., Liu Y. & Xiao Y. Method for Isolating Cross-Reactive Aptamer and Use Thereof, 2021-07-13, 美国, 17/117,317 (专利)
Xiao Y., Luo Y. & Yu H.; Material and Method for Colorimetric Detection of Small-Molecule Targets, 2021-03-16, 美国, 16/902,717 (专利)
Xiao Y. & Yu H. Aptamers That Bind to Natural and Synthetic Cannabinoids, 2021-02-02, 美国, 16/901,723 (专利)
Xiao Y. & Yu H.; Materials and Methods for Rapid and Specific Detection of Synthetic Cathinones, 2020-06-16, 美国, 15/900,061 (专利)
