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王灿
职称:副教授
邮箱:wangcan1993@cpu.edu.cn
学院:生命科学与技术学院
实验室:江宁校区学院实验楼一期102室
招生学科:生物学,生物与医药
办公室:江宁校区学院实验楼一期325室
个人简历

·Wang, C., Tay, L., Hu, W., Corre, M., & Graille, M. (2025). TRMT112, a master activator of several methyltransferases modifying factors involved in RNA maturation and translation. Frontiers in RNA research, doi: 10.3389/frnar.2025.1556979.

·Wang, C., Ulryck, N., Herzel, L., Pythoud, N., Kleiber, N., Guerineau, V., Jactel, V., Moritz, C., Bohnsack, M. T., Carapito, C., Touboul, D., Bohnsack, K. E., & Graille, M. (2023). N 2-methylguanosine modifications on human tRNAs and snRNA U6 are important for cell proliferation, protein translation and pre-mRNA splicing. Nucleic Acids Res, 51(14), 7496-7519. https://doi.org/10.1093/nar/gkad487

·Wang, C., van Tran, N., Jactel, V., Guerineau, V., & Graille, M. (2020). Structural and functional insights into Archaeoglobus fulgidus m2G10 tRNA methyltransferase Trm11 and its Trm112 activator. Nucleic Acids Res, 48(19), 11068-11082. https://doi.org/10.1093/nar/gkaa830


研究方向

1. RNA修饰在肿瘤发生过程中的作用机制及探究其作为基因检测标记物的潜质;

2. 分子层面探究生物大分子(如剪接体,核糖体及RNA-蛋白复合物)的缺陷与疾病早期的关系。


主持在研项目情况

·中国药科大学高层次人才科研启动经费(主持


近年代表性科研成果

·Wang, C., Tay, L., Hu, W., Corre, M., & Graille, M. (2025). TRMT112, a master activator of several methyltransferases modifying factors involved in RNA maturation and translation. Frontiers in RNA research, doi: 10.3389/frnar.2025.1556979.

·Wang, C., Ulryck, N., Herzel, L., Pythoud, N., Kleiber, N., Guerineau, V., Jactel, V., Moritz, C., Bohnsack, M. T., Carapito, C., Touboul, D., Bohnsack, K. E., & Graille, M. (2023). N 2-methylguanosine modifications on human tRNAs and snRNA U6 are important for cell proliferation, protein translation and pre-mRNA splicing. Nucleic Acids Res, 51(14), 7496-7519. https://doi.org/10.1093/nar/gkad487

·Wang, C., van Tran, N., Jactel, V., Guerineau, V., & Graille, M. (2020). Structural and functional insights into Archaeoglobus fulgidus m2G10 tRNA methyltransferase Trm11 and its Trm112 activator. Nucleic Acids Res, 48(19), 11068-11082. https://doi.org/10.1093/nar/gkaa830