靶向RNA和RNA结合蛋白的小分子药物发现

与RNA剪接相关的靶点发现和药物开发

中国药科大学高层次人才科研启动经费（主持）

1. Zhichao Tang^†, Shalakha Hegde^†, Siyuan Hao, Manikandan Selvaraju, Jianming Qiu, Jingxin Wang*. Chemical-guided SHAPE sequencing (cgSHAPE-seq) informs the binding site of RNA-degrading chimeras targeting SARS-CoV-2 5’ untranslated region, Nature Communications, 16, 483 (2025).

2. Zhichao Tang, Sana Akhter, Ankita Ramprasad, Xiao Wang, Mikhail Reibarkh, Jinan Wang, Sadikshya Aryal, Srinivas S Thota, Junxing Zhao, Justin T Douglas, Philip Gao, Erik D Holmstrom, Yinglong Miao, Jingxin Wang*. Recognition of single-stranded nucleic acids by small-molecule splicing modulators, Nucleic Acids Research2021, 49(14), 7870–7883.

3. Shalakha Hegde^†, Sana Akhter^†, Zhichao Tang^†, Chang Qi, Chenguang Yu, Anna Lewicka, Yu Liu, Kushal Koirala, Mikhail Reibarkh, Kevin P. Battaile, Anne Cooper, Scott Lovell, Erik D. Holmstrom, Xiao Wang, Joseph A. Piccirilli, Qi Gao*, Yinglong Miao*, Jingxin Wang*.Mechanistic Studies of Small Molecule Ligands Selective to RNA Single GBulges. Nucleic Acids Research2025, 53(12), gkaf559.

4. Zhichao Tang^†, Junxing Zhao^†, Ying Li^†, Shallu Tomer, Manikandan Selvaraju, Nicholas Tien, Diyun Sun, David K. Johnson, Anjie Zhen, Pingwei Li, Jingxin Wang*. Structural and Biological Evaluations of a Non-Nucleoside STING Agonist Specific for Human STINGA230 Variants. ACS Med. Chem. Lett.2024, 15, 5, 653–658.

5. Zhichao Tang^†, Shalakha Hegde^†, Junxing Zhao^†, Shoutian Zhu, Kristen A. Johnson, Christian L. Lorson, Jingxin Wang*. CRISPR-Mediated Enzyme Fragment Complementation Assay for Quantification of the Stability of Splice Isoforms, ChemBioChem2022, doi: 10.1002/cbic.202200012.

6. Junxing Zhao, Zhichao Tang, Manikandan Selvaraju, Kristen A. Johnson, Justin T. Douglas, Philip F. Gao, H. Michael Petrassi, Michael Zhuo Wang, Jingxin Wang*. Cellular Target Deconvolution of Small Molecules Using a Selection-Based Genetic Screening Platform, ACS Central Science2022, doi.org/10.1021/acscentsci.2c00609.