1）免疫细胞治疗实体肿瘤的创新药物开发
2）新型多功能融合受体的高通量筛选与研究
3）创新型肿瘤疫苗药物的研究
4）基于AI设计的重组人胶原蛋白的合成生物学研究
1）免疫细胞治疗实体肿瘤的创新药物开发
2）新型多功能融合受体的高通量筛选与研究
3）创新型肿瘤疫苗药物的研究
4）基于AI设计的重组人胶原蛋白的合成生物学研究
（1）主持国家科技部十一五医药重大专项“虫草多糖胶囊治疗慢性肾病新药的临床前研究”；
（2）主持国家科技部十二五医药重大专项“虫草多糖治疗慢性肾功能衰竭新药的临床研究”（批准号：2011ZX09101-009-02，时间：2011.1-2014.12）
（3）主持国家自然科学基金面上项目“虫草多糖对TGF-β1介导的慢性肾功能衰竭作用机制研究”（批准号：81173527， 时间：2012.1-2015.12）。
（4）主持国家自然科学基金面上项目“基于“肠道菌群-SCFAs-GPCR/HDAC-mTOR”研究虫草多糖治疗慢性肾病的作用机制（批准号：81773985）2018.1-2021.12
近年代表性科研成果
（1）Wang M, Zhang Z, Yang Y, Peng X, Yin H. A targeted MAVS fusion protein for controlled innate immune activation and antitumor therapy. Oncoimmunology. 2025 Dec;14(1):2478850.
（2）Wang C, Zhang Z, Zha Z, Lu C, Wang H, Yue L, Yin H. Characterization of Recombinant Human Type II Collagen from CHO Cells, Functional Assessment of Chondrocytes and Alleviation of Cartilage Degeneration. Int J Mol Sci. 2025 Oct 21;26(20):10232.
（3）Sun R, Yang X, Liu S, Wang T, Du P, Yang Y, Hua Z, Zha Z, Fan M, Yang M, Yin H. A novel long-acting recombinant follicle-stimulating hormone with hyperglycosylation exhibits improved pharmacokinetic and bioactivity on promoting follicle growth. Biochem Pharmacol. 2025 Jul;237:116944.
（4）Du P, Wang T, Wang R, Liu S, Wang H, Yin H. A Novel Recombinant Human FGF21 Analog with High Glycosylation Has a Prolonged Half-Life and Affects Glycemic and Body Weight Control. Int J Mol Sci. 2025 Mar 16;26(6):2672.
（5）Liu S, Wang J, Li Y, Wang M, Du P, Zhang Z, Li W, Sun R, Fan M, Yang M, Yin H. A Multivalent mRNA Therapeutic Vaccine Exhibits Breakthroughs in Immune Tolerance and Virological Suppression of HBV by Stably Presenting the Pre-S Antigen on the Cell Membrane. Pharmaceutics. 2025 Feb 7;17(2):211.
（6）Wang C, Guo X, Fan M, Yue L, Wang H, Wang J, Zha Z, Yin H. Production of recombinant human type I collagen homotrimers in CHO cells and their physicochemical and functional properties. J Biotechnol. 2024 Nov 20;395:149-160.
（7）Tang H, Li Q, Zha Z, Jiao Y, Yang B, Cheng Z, Wang T, Yin H. Xylan acetate ester ameliorates ulcerative colitis through intestinal barrier repair and inflammation inhibition via regulation of macrophage M1 polarization. Int J Biol Macromol. 2024 Sep 12;280(Pt 1):135551.
（8）Tang H, Zha Z, Tan Y, Li Y, Jiao Y, Yang B, Xiong Q, Yin H, Wang H. Extraction and characterization of polysaccharide from fermented mycelia of Coriolus versicolor and its efficacy for treating nonalcoholic fatty liver disease. Int J Biol Macromol. 2023 Sep 1;248:125951.
（9）Zhang Z, Liu C, Wang M, Sun R, Yang Z, Hua Z, Wu Y, Wu M, Wang H, Qiu W, Yin H, Yang M. Treating solid tumors with TCR-based chimeric antigen receptor targeting extra domain B-containing fibronectin. J Immunother Cancer. 2023 Aug;11(8):e007199.
（10）Zha Z, Wang X, Wang G, Yin H, Wang H. Synthesis and structural characterization of xylan acetate ester and its antinephritic effects in rats with experimental chronic kidney disease. Int J Biol Macromol. 2023 Jun 15;240:124413.
（11）Zha Z, Miao Y, Tang H, Herrera-Balandrano DD, Yin H, Wang SY. Heparosan-based self-assembled nanocarrier for zinc(II) phthalocyanine for use in photodynamic cancer therapy. Int J Biol Macromol. 2022 Oct 31;219:31-43.
（12）Zhang Z, Liu C, Yang Z, Yin H. CAR-T-Cell Therapy for Solid Tumors Positive for Fibronectin Extra Domain B. Cells. 2022 Sep 14;11(18):2863.
（13）Du P, Wang T, Wang H, Yang M, Yin H. Mucin-fused myeloid-derived growth factor (MYDGF164) exhibits a prolonged serum half-life and alleviates fibrosis in chronic kidney disease. Br J Pharmacol. 2022 Aug;179(16):4136-4156.
（14）Zha Z, Liu Y, Miao Y, Liao S, Wang SY, Tang H, Yin H. Preparation and characterization of 2-deacetyl-3-O-sulfo-heparosan and its antitumor effects via the fibroblast growth factor receptor pathway. Int J Biol Macromol. 2022 Mar 15;201:47-58.
（15）Li R , Kassaye H , Pan Y , Shen Y , Li W , Cheng Y , Guo J , Xu Y , Yin H , Yuan Z . A visible and near-infrared dual-fluorescent probe for discrimination between Cys/Hcy and GSH and its application in bioimaging. Biomater Sci. 2020 Nov 7;8(21):5994-6003.
（16）Zha Z, Lv Y, Tang H, Li T, Miao Y, Cheng J, Wang G, Tan Y, Zhu Y, Xing X, Ding K, Wang Y, Yin H. An orally administered butyrate-releasing xylan derivative reduces inflammation in dextran sulphate sodium-induced murine colitis. Int J Biol Macromol. 2020 Aug 1;156:1217-1233.
（17）Zha Z, Zhang Z, Wei W, Nie W, Chu W, Huang F, Yue L, Wang SY, Yin H. Isolation, structural characterization of polysaccharide from Cephalosporium sinensis mycelia and its anti-nephritic effects in adenine-induced CKD rats. Int J Biol Macromol. 2020 Jul 15;155:340-349.
（18）Tang H, Nie W, Xiao J, Zha Z, Chen Q, Yin H. Structural characterization and anti-inflammatory effect in hepatocytes of a galactoglucan from Antrodia camphorata mycelium. RSC Adv. 2019 Mar 8;9(14):7664-7672.
（19）Zha Z, Wang SY, Chu W, Lv Y, Kan H, Chen Q, Zhong L, Yue L, Xiao J, Wang Y, Yin H. Isolation, purification, structural characterization and immunostimulatory activity of water-soluble polysaccharides from Lepidium meyenii. Phytochemistry. 2018 Mar;147:184-193.
（20）Zhou S, Zhang A, Yin H, Chu W. Bacillus sp. QSI-1 Modulate Quorum Sensing Signals Reduce Aeromonas hydrophila Level and Alter Gut Microbial Community Structure in Fish. Front Cell Infect Microbiol. 2016 Dec 12;6:184.
（21）Lin S, Lyu X, Yu J, Sun L, Du D, Lai Y, Li H, Wang Y, Zhang L, Yin H, Yuan S. MHP-1 inhibits cancer metastasis and restores topotecan sensitivity via regulating epithelial-mesenchymal transition and TGF-β signaling in human breast cancer cells. Phytomedicine. 2016 Sep 15;23(10):1053-63.
（22）Yue L, Wang W, Wang Y, Du T, Shen W, Tang H, Wang Y, Yin H. Bletilla striata polysaccharide inhibits angiotensin II-induced ROS and inflammation via NOX4 and TLR2 pathways. Int J Biol Macromol. 2016 Aug;89:376-88.
