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沈辉
职称:教授
邮箱:shhui@cpu.edu.cn
学院:生命科学与技术学院
实验室:江宁校区学院实验楼一期219室
招生学科:生物学,微生物与生化药学
办公室:江宁校区学院实验楼一期204室
个人简历

1. MinZhou, HuiShe#, ChuanHuang#. Lysosomes join the circular RNA decay machinery. Trends in Cell Biology (2026).

2. Shiyuan Chen*, Canchen*, Wang, Junyi Hu, Ting Luo, Qian Li#, Hui Shen#. Noncoding RNAs are indispensable architects and regulators of biomolecular condensates. Non-coding RNA Research(2026).

3. Minxiang Zhong*, Shiyuan Chen*, Wengqi Lu, Ting Luo, Ruiya Shi, Jinzhou Li, Hui Shen#. Liquid-liquid phase separation of DDX3X: mechanisms, pathological implications, and therapeutic potential. International Journal of Biological Macromolecules (2025).

4. Michael C Owens*, Hui Shen*, Amber Yanas, Maria Saraí Mendoza-Figueroa, Ellen Lavorando, Xiaoyu Wei, Him Shweta, Hsin-Yao Tang, Yale E Goldman#, Kathy Fange Liu#. Specific catalytically impaired DDX3X mutants form sexually dimorphic hollow condensates. Nature Communications (2024).

5. Yulia Gonskikh*, Julian Stoute*, Hui Shen*, Krista Budinich, Bianca Pingul, Kollin Schultz, Heidi Elashal, Ronen Marmorstein, Junwei Shi, Kathy Fange Liu#. Noncatalytic regualtion of 18S rRNA methyltransferase DIMT1 in acute myeloid leukemia. Genes and Development (2023).

6. Hui Shen*, Amber Yanas*, Michael C Owens, Celia Zhang, Clark Fritsch, Charlotte M Fare, Katie E Copley, James Shorter, Yale E Goldman, Kathy Fange Liu#. Sexually dimorphic RNA helicases DDX3X and DDX3Y differentially regulate RNA metabolism through phase separation. Molecular cell (2022).

7. Hui Shen, Yulia Gonskikh, Julian Stoute, Kathy Fange Liu#. Human DIMT1 generates N26, 6A-dimethylation–containing small RNAs. Journal of Biological Chemistry (2021).

8. Hui Shen, Robert Jordan Ontiveros, Michael C Owens, Monica Yun Liu, Uday Ghanty, Rahul M Kohli, Kathy Fange Liu#. Journal of Biological Chemistry (2021).

9. Hui Shen, Julian Stoute, Kathy Fange Liu#. Structural and catalytic roles of the human 18S rRNA methyltransferases DIMT1 in ribosome assembly and translation. Journal of Biological Chemistry (2020).

10. R Jordan Ontiveros*, Hui Shen*, Julian Stoute, Amber Yanas, Yixiao Cui, Yuyu Zhang, Kathy Fange Liu#. Coordination of mRNA and tRNA methylations by TRMT10A. Proceedings of the National Academy of Sciences (2020).

11. Shuhuai Yu*, Hui Shen*, Yuanyuan Cheng, Yingying Zhu, Xu Li#, Wanmeng Mu#. Structural and functional basis of difructose anhydride III hydrolase, which sequentially converts inulin using the same catalytic residue. ACS Catalysis (2018).

12. Hui Shen*, Yuwei Zhu*, Chongyuan Wang, Hui Yan, Maikun Teng, Xu Li#. Structural and histone binding ability characterization of the ARB2 domain of a histone deacetylase Hda1 from Saccharomyces cerevisiae. Scientific reports (2016).

13. Hui Shen*, Hong Wang*, Qiao Liu, Huihui Liu, Maikun Teng, Xu Li#. Structural insights into RNA recognition properties of glyceraldehyde3phosphate dehydrogenase 3 from Saccharomyces cerevisiae. IUBMB life (2014).

14. Hui Shen, Huihui Liu, Hong Wang, Maikun Teng, Xu Li#. Preliminary crystallographic analysis of RraB from Escherichia coli. Acta Crystallographica Section F: Structural Biology and Crystallization Communications (2013).





研究方向

RNA结合蛋白液-液相分离性质在基因表达调控中的功能及机制


主持在研项目情况


1. 2024年江苏省青年基金项目(BK20241585)。

2. 2024年南京市留学人员科技创新项目择优资助。

3. 国自然青年基金(32500485)。



近年代表性科研成果

1. MinZhou, HuiShe#, ChuanHuang#. Lysosomes join the circular RNA decay machinery. Trends in Cell Biology (2026).

2. Shiyuan Chen*, Canchen*, Wang, Junyi Hu, Ting Luo, Qian Li#, Hui Shen#. Noncoding RNAs are indispensable architects and regulators of biomolecular condensates. Non-coding RNA Research(2026).

3. Minxiang Zhong*, Shiyuan Chen*, Wengqi Lu, Ting Luo, Ruiya Shi, Jinzhou Li, Hui Shen#. Liquid-liquid phase separation of DDX3X: mechanisms, pathological implications, and therapeutic potential. International Journal of Biological Macromolecules (2025).

4. Michael C Owens*, Hui Shen*, Amber Yanas, Maria Saraí Mendoza-Figueroa, Ellen Lavorando, Xiaoyu Wei, Him Shweta, Hsin-Yao Tang, Yale E Goldman#, Kathy Fange Liu#. Specific catalytically impaired DDX3X mutants form sexually dimorphic hollow condensates. Nature Communications (2024).

5. Yulia Gonskikh*, Julian Stoute*, Hui Shen*, Krista Budinich, Bianca Pingul, Kollin Schultz, Heidi Elashal, Ronen Marmorstein, Junwei Shi, Kathy Fange Liu#. Noncatalytic regualtion of 18S rRNA methyltransferase DIMT1 in acute myeloid leukemia. Genes and Development (2023).

6. Hui Shen*, Amber Yanas*, Michael C Owens, Celia Zhang, Clark Fritsch, Charlotte M Fare, Katie E Copley, James Shorter, Yale E Goldman, Kathy Fange Liu#. Sexually dimorphic RNA helicases DDX3X and DDX3Y differentially regulate RNA metabolism through phase separation. Molecular cell (2022).

7. Hui Shen, Yulia Gonskikh, Julian Stoute, Kathy Fange Liu#. Human DIMT1 generates N26, 6A-dimethylation–containing small RNAs. Journal of Biological Chemistry (2021).

8. Hui Shen, Robert Jordan Ontiveros, Michael C Owens, Monica Yun Liu, Uday Ghanty, Rahul M Kohli, Kathy Fange Liu#. Journal of Biological Chemistry (2021).

9. Hui Shen, Julian Stoute, Kathy Fange Liu#. Structural and catalytic roles of the human 18S rRNA methyltransferases DIMT1 in ribosome assembly and translation. Journal of Biological Chemistry (2020).

10. R Jordan Ontiveros*, Hui Shen*, Julian Stoute, Amber Yanas, Yixiao Cui, Yuyu Zhang, Kathy Fange Liu#. Coordination of mRNA and tRNA methylations by TRMT10A. Proceedings of the National Academy of Sciences (2020).

11. Shuhuai Yu*, Hui Shen*, Yuanyuan Cheng, Yingying Zhu, Xu Li#, Wanmeng Mu#. Structural and functional basis of difructose anhydride III hydrolase, which sequentially converts inulin using the same catalytic residue. ACS Catalysis (2018).

12. Hui Shen*, Yuwei Zhu*, Chongyuan Wang, Hui Yan, Maikun Teng, Xu Li#. Structural and histone binding ability characterization of the ARB2 domain of a histone deacetylase Hda1 from Saccharomyces cerevisiae. Scientific reports (2016).

13. Hui Shen*, Hong Wang*, Qiao Liu, Huihui Liu, Maikun Teng, Xu Li#. Structural insights into RNA recognition properties of glyceraldehyde3phosphate dehydrogenase 3 from Saccharomyces cerevisiae. IUBMB life (2014).

14. Hui Shen, Huihui Liu, Hong Wang, Maikun Teng, Xu Li#. Preliminary crystallographic analysis of RraB from Escherichia coli. Acta Crystallographica Section F: Structural Biology and Crystallization Communications (2013).