1. 国家自然科学基金委员会, 面上项目, 82171751, 自噬下调cGAS-STING信号的新功能与分子机制研究, 2022-01-01 至 2025-12-31, 60万元, 在研, 主持
2. 中华人民共和国科学技术部, 国家重点研发计划, 2021YFF0702000, 基于新靶点的重大传染病人源化 动物模型研发, 2021-12 至 2025-11, 365万元, 在研, 主持
3. 国家自然科学基金委员会，创新研究群体项目，82321005，代谢调控与药物靶标发现，2024-01-01至2028-12-31，1000万元，在研，参与
4. 中华人民共和国科学技术部,国家重点研发计划, 2022YFC2303200, 重要感染中病原-共生微生物-宿 主互作和干预, 2022-12 至 2025-11, 122.5万元, 在研, 参与
5. 国家自然科学基金委员会, 重点项目, 31730018, cGAS-STING信号转导通路的调控新机制及相关先导 化合物研究, 2018-01-01 至 2022-12-31, 308万元, 资助期满, 主持
1. Mingyu Pan; Tongyu Hu; Jiao Lyu; Yue Yin; Jing Sun; Quanyi Wang; Lingxiao Xu; Haiyang Hu; Chen Wang; CSNK1A1/CK1α suppresses autoimmunity by restraining the CGAS-STING1 signaling, Autophagy, 2024, 20(3)
2. Ze Hong; Saihua Chen; Jing Sun; Dan Cheng; Hanli Guo; Jiahao Mei; Xiang Zhang; Munire Maimaiti; Haiping Hao; Peng Cao; Haiyang Hu; Chen Wang; STING signaling in islet macrophages impairs insulin secretion in obesity, Sci China Life Sci, 2023, Oct(25)
3. Mingyu Pan; Yue Yin; Tongyu Hu; Xinxia Wang; Tian Jia; Jing Sun; Quanyi Wang; Wei Meng; Juanjuan Zhu; Chunsun Dai; Haiyang Hu; Chen Wang ; UXT attenuates the CGAS-STING1 signaling by targeting STING1 for autophagic degradation, Autophagy, 2022, 19(2)
4. Ze Hong; Jiahao Mei; Chenhui Li; Guohui Bai; Munire Maimaiti; Haiyang Hu; Wenying Yu; Li Sun; Lele Zhang; Dan Cheng; Yixian Liao; Senlin Li; Yanping You; Hongbin Sun; Jing Huang; Xing Liu; Judy Lieberman; Chen Wang; STING inhibitors target the cyclic dinucleotide binding pocket, Proc Natl Acad Sci U S A, 2021, 118(24)
5. Chenhui Li; Lele Zhang; Dong Qian; Mingxing Cheng; Haiyang Hu; Ze Hong; Ye Cui; Huansha Yu; Quanyi Wang; Juanjuan Zhu; Wei Meng; Jinfu Xu; Yi Sun; Peng Zhang; Chen Wang ; RNF111- facilitated Neddylation Potentiates cGAS-mediated Antiviral Innate Immune Response, PLOS Pathogens, 2021, 17(3)
6. Ze Hong; Tianchi Ma; Xing Liu; Chen Wang; cGAS‐STING pathway: post‐translational modifications and functions in sterile inflammatory diseases, The FEBS Journal, 2021, 289(20)
7. Shufang Cui; Qiuya Yu; Lei Chu; Ye Cui; Ming Ding; Quanyi Wang; Hongyun Wang; Yu Chen; Xing Liu; Chen Wang ; Nuclear cGAS Functions Non-canonically to Enhance Antiviral Immunity via Recruiting Methyltransferase Prmt5, Cell Reports, 2020, 33(10)
8. Mingyu Pan; Yue Yin; Xinxia Wang; Quanyi Wang; Lele Zhang; Haiyang Hu; Chen Wang ; Mice deficient in UXT exhibit retinitis pigmentosa-like features via aberrant autophagy activation, Autophagy, 2020, 17(8)
9. Lele Zhang; Ning Wei; Ye Cui; Ze Hong; Xing Liu; Qiang Wang; Senlin Li; Heng Liu; Huansha Yu; Yanni Cai; Quanyi Wang; Juanjuan Zhu; Wei Meng; Zhengjun Chen; Chen Wang; The deubiquitinase CYLD is a specific checkpoint of the STING antiviral signaling pathway, PLoS Pathogens, 2018, 14(11)
10. Senlin Li; Ze Hong; Zhe Wang; Fei Li; Jiahao Mei; Lulu Huang; Xiwen Lou; Simeng Zhao; Lihua Song; Wei Chen; Qiang Wang; Heng Liu; Yanni Cai; Huansha Yu; Huimin Xu; Guangzhi Zeng; Quanyi Wang; Juanjuan Zhu; Xing Liu; Ninghua Tan; Chen Wang; The cyclopeptide Astin C specifically inhibits the innate immune CDN sensor STING, Cell Reports, 2018, 25(12)
