1. Shi R, Tao Y, Tang H, Wu C, Fei J, Ge H, Gu HF*, Wu J*, Abelmoschus Manihot ameliorates the levels of circulating metabolites in diabetic 2 nephropathy by modulating gut microbiota in NOD mice. Microbial Biotechnology 2023 Apr;16(4): 813–826
2. Wu C, Song Y, Yu Y, Xu Q, Cui X, Wang Y, Wu J*, Gu HF*. Single-Cell Transcriptional Landscape Reveals the Regulatory Network and Its Heterogeneity of Renal Mitochondrial Damages in Diabetic Kidney Disease. Int J Mol Sci. 2023 Aug 31;24(17):13502
3. Wang P†, Liu D†, Zhou Z, Liu F, Shen Y, You Q, Lu S*, Wu J*,The role of protein arginine deiminase 4-dependent neutrophil extracellular traps formation in ulcerative colitis. Front Immunol 2023,14: 1144976
4. You Q, Shen Y, Wu Y, Li Y, Liu C, Huang F, Gu HF*, Wu J*, Neutrophil Extracellular Traps Caused by Gut Leakage Trigger the Autoimmune Response in Nonobese Diabetic Mice. Front Immunol 2022,12:711423
5. Shen Y, You Q, Wu Y, Wu J*, Inhibition of PAD4-mediated NET formation by clamidine prevents diabetes development in nonobese diabetic mice, Eur J Pharmacol 2021 Nov 09
6. Dong W, Liu D, Zhang T, You Q, Huang F, Wu J*,Oral delivery of staphylococcal nuclease ameliorates DSS induced ulcerative colitis in mice via degrading intestinal neutrophil extracellular traps,Ecotoxicology and Environmental Safety,2021,215:112161
7. Chen Y, Wu J, Wang J, Zhang W, Xu B, Xu X, Zong L*Targeted delivery of antigen to intestinal dendritic cells induces oral tolerance and prevents autoimmune diabetes in NOD mice,Diabetologia,2018 Jun;61(6):1384-96
8. Lang J, Wang X, Liu K, He D, Niu P, Cao R, Jin L, Wu J*. Oral delivery of staphylococcal nuclease by Lactococcus lactis prevents type 1 diabetes mellitus in NOD mice.Appl Microbiol Biotechnol. 2017 Sep, 101:7653–62
1、mRNA疫苗在内的各种新型疫苗研制;
2、自身免疫性疾病(IBD,T1D等)发病机理与靶标发现;
3、肠道微生物与疾病。
l 国家自然科学基金面上项目(NETs在溃疡性结肠炎肠道粘膜损伤中的致病机理及干预研究,No:81973224)
l 国家自然科学基金面上项目(葡萄球菌核酸酶介导NETs降解在T1DM防治中的作用机制研究,No:81673340)
l 国家自然科学基金面上项目(乳酸菌在粘膜给药疫苗递呈载体中的应用,No:81172973)
l 江苏省基础研究计划(自然科学基金)(乳酸菌递呈的葡萄球菌核酸酶在T1DM防治中的作用与机制研究,No:BK20161462)
l 国家自然科学基金青年基金(疫苗多肽纳米载药新分子的研究,No:30500458)
1. Shi R, Tao Y, Tang H, Wu C, Fei J, Ge H, Gu HF*, Wu J*, Abelmoschus Manihot ameliorates the levels of circulating metabolites in diabetic 2 nephropathy by modulating gut microbiota in NOD mice. Microbial Biotechnology 2023 Apr;16(4): 813–826
2. Wu C, Song Y, Yu Y, Xu Q, Cui X, Wang Y, Wu J*, Gu HF*. Single-Cell Transcriptional Landscape Reveals the Regulatory Network and Its Heterogeneity of Renal Mitochondrial Damages in Diabetic Kidney Disease. Int J Mol Sci. 2023 Aug 31;24(17):13502
3. Wang P†, Liu D†, Zhou Z, Liu F, Shen Y, You Q, Lu S*, Wu J*,The role of protein arginine deiminase 4-dependent neutrophil extracellular traps formation in ulcerative colitis. Front Immunol 2023,14: 1144976
4. You Q, Shen Y, Wu Y, Li Y, Liu C, Huang F, Gu HF*, Wu J*, Neutrophil Extracellular Traps Caused by Gut Leakage Trigger the Autoimmune Response in Nonobese Diabetic Mice. Front Immunol 2022,12:711423
5. Shen Y, You Q, Wu Y, Wu J*, Inhibition of PAD4-mediated NET formation by clamidine prevents diabetes development in nonobese diabetic mice, Eur J Pharmacol 2021 Nov 09
6. Dong W, Liu D, Zhang T, You Q, Huang F, Wu J*,Oral delivery of staphylococcal nuclease ameliorates DSS induced ulcerative colitis in mice via degrading intestinal neutrophil extracellular traps,Ecotoxicology and Environmental Safety,2021,215:112161
7. Chen Y, Wu J, Wang J, Zhang W, Xu B, Xu X, Zong L*Targeted delivery of antigen to intestinal dendritic cells induces oral tolerance and prevents autoimmune diabetes in NOD mice,Diabetologia,2018 Jun;61(6):1384-96
8. Lang J, Wang X, Liu K, He D, Niu P, Cao R, Jin L, Wu J*. Oral delivery of staphylococcal nuclease by Lactococcus lactis prevents type 1 diabetes mellitus in NOD mice.Appl Microbiol Biotechnol. 2017 Sep, 101:7653–62