1. Liu, S.-S., Jiang, T.-X., …, Li, N-N.*, Gao, N.* & Qiu, X.-B.* (2024). Molecular mechanisms underlying the BIRC6-mediated regulation of apoptosis and autophagy. Nature Communications 15(1):891.
2. Chai, Q., …, Qiu, X.-B.*, Wang, J.*, Liu, C.H.*. (2022) A bacterial phospholipid phosphatase inhibits host pyroptosis by hijacking ubiquitin. Science 378(6616):eabq0132.
3. Wang, J., Ge, P., Lei, Z., ..., Gao, G.F. *, Qiu, X.-B. *, Liu, C.H. *(2021)Mycobacterium tuberculosis protein kinase G acts as an unusual ubiquitinating enzyme to impair host immunity. EMBO Reports 22(6): e52175.
4. Jiang, T.X., …, Lin, K.* and Qiu, X.-B. * (2021). Proteasome activator PA200 maintains stability of histone marks during transcription and aging. Theranostics 11(3): 1458-1472.
5. Jiang, T.X., Zhou, J.B., Zhu, Q.Q., …, Goldberg, A.L. *, and Qiu, X.B.*. (2019). SIP/CacyBP Promotes Autophagy by Regulating Levels of BRUCE/Apollon, which Stimulates LC3-I Degradation. Proc. Natl. Acad. Sci. USA 116:13404-13413.
6. Jiang, T.X.*, Zhao, M., and Qiu, X.B.* (2018). Substrate receptors of proteasomes. Biological Reviews 93, 1765-1777
7. Wang, J., Li, B.-X., Ge, P.-P., Li, J., Wang, Q., Gao, G.F.*, Qiu, X.-B.*, and Liu, C.H.* (2015) Mycobacterium tuberculosis suppresses innate immunity by coopting the host ubiquitin system. Nature Immunology 16, 237-245.
8. Qian, M., ..., Wang, L., Goldberg, A.L., Shen, Y., and Qiu, X.-B.*. (2013) Acetylation-Mediated Proteasomal Degradation of Core Histones during DNA Repair and Spermatogenesis. Cell 153, 1012-1024.
9. Qiu, X.B.*, Ouyang, S.Y., Li, C.J., Miao, S., Wang, L., and Goldberg, A.L. * (2006) hRpn13/ADRM1/GP110 is a novel proteasome subunit that binds the deubiquitinating enzyme, UCH37. EMBO J. 25,5742-5753.
10. 邱小波*、张宏、王琛和王琳芳 主编。《泛素家族介导的蛋白质降解和细胞自噬》,科学出版社,2020年6月。
蛋白质降解及其靶向药物研发 |
1、国家基金委原创探索计划项目,直接结合蛋白酶体的非泛素依赖型蛋白水解靶向嵌合体NUTAC技术的研发, 82350006, 2024.1-2026.12,项目负责人。
2、国家基金委重点项目,蛋白酶体介导蛋白质降解、细胞稳态及相关信号转导的机制,32330027,2024.1-2028.12,项目负责人。
3、国家重点研发计划(发育编程及其代谢调节专项)项目,代谢性细胞器对神经组织、睾丸等发育的调节作用及其机制,2019YFA0802100,2019.12-2024.11,项目负责人。
1. Liu, S.-S., Jiang, T.-X., …, Li, N-N.*, Gao, N.* & Qiu, X.-B.* (2024). Molecular mechanisms underlying the BIRC6-mediated regulation of apoptosis and autophagy. Nature Communications 15(1):891.
2. Chai, Q., …, Qiu, X.-B.*, Wang, J.*, Liu, C.H.*. (2022) A bacterial phospholipid phosphatase inhibits host pyroptosis by hijacking ubiquitin. Science 378(6616):eabq0132.
3. Wang, J., Ge, P., Lei, Z., ..., Gao, G.F. *, Qiu, X.-B. *, Liu, C.H. *(2021)Mycobacterium tuberculosis protein kinase G acts as an unusual ubiquitinating enzyme to impair host immunity. EMBO Reports 22(6): e52175.
4. Jiang, T.X., …, Lin, K.* and Qiu, X.-B. * (2021). Proteasome activator PA200 maintains stability of histone marks during transcription and aging. Theranostics 11(3): 1458-1472.
5. Jiang, T.X., Zhou, J.B., Zhu, Q.Q., …, Goldberg, A.L. *, and Qiu, X.B.*. (2019). SIP/CacyBP Promotes Autophagy by Regulating Levels of BRUCE/Apollon, which Stimulates LC3-I Degradation. Proc. Natl. Acad. Sci. USA 116:13404-13413.
6. Jiang, T.X.*, Zhao, M., and Qiu, X.B.* (2018). Substrate receptors of proteasomes. Biological Reviews 93, 1765-1777
7. Wang, J., Li, B.-X., Ge, P.-P., Li, J., Wang, Q., Gao, G.F.*, Qiu, X.-B.*, and Liu, C.H.* (2015) Mycobacterium tuberculosis suppresses innate immunity by coopting the host ubiquitin system. Nature Immunology 16, 237-245.
8. Qian, M., ..., Wang, L., Goldberg, A.L., Shen, Y., and Qiu, X.-B.*. (2013) Acetylation-Mediated Proteasomal Degradation of Core Histones during DNA Repair and Spermatogenesis. Cell 153, 1012-1024.
9. Qiu, X.B.*, Ouyang, S.Y., Li, C.J., Miao, S., Wang, L., and Goldberg, A.L. * (2006) hRpn13/ADRM1/GP110 is a novel proteasome subunit that binds the deubiquitinating enzyme, UCH37. EMBO J. 25,5742-5753.
10. 邱小波*、张宏、王琛和王琳芳 主编。《泛素家族介导的蛋白质降解和细胞自噬》,科学出版社,2020年6月。