马磊

职称：教授

邮箱： malei@cpu.edu.cn

学院：生命科学与技术学院

实验室：

招生学科：生物学

办公室：江宁校区学院实验楼二期411室

个人简历

马磊，特聘研究员，博士生导师，课题组长，入选国家级青年人才项目和江苏省特聘教授。依托学校一流的药学相关专业和创新平台，马磊课题组长期致力于神经科学前沿技术的研究。2015年毕业于北京大学生命科学学院，2017年进入Vollum Institute进行博士后研究，2022年在Vollum Institute升职为Staff scientist。 2024年作为独立PI加入中国药科大学生命科学与技术学院，并获得学校高层次人才计划支持。近年来以第一作者（含共同）发表在Nature（独立一作）、Nature Neuroscience、Neuron等国际知名期刊。

研究方向

1.探究腺苷的释放来源及其对动物行为的调控机制。

2.探究胆碱能神经元调节纹状体神经元PKA及动物行为的作用机制。

3.探究多巴胺缺失对纹状体神经元PKA的影响，并以此为依据，开发出以PKA为靶标来干预和治疗多巴胺紊乱相关疾病的新型策略。

4.探究睡眠剥夺后PKA的变化及其对学习记忆和情绪的影响。

主持在研项目情况

1.中国国家博士后基金（主持） 2015M580920 11/05/2015 -06/01/2017 5万

2. 深圳市科技创新基金（主持） JCYJ20160428154351820 睡眠期间钙离子树突峰电位对阿尔茨海默症发病进程的影响 06/23/2016–06/30/2018 40万

3. 深圳市科技创新基金（主持） JCYJ20170807144417251学习过程中钙离子树突峰电位和新树突棘的相互关系研究 03/09/2018–03/31/2020 50万

近年代表性科研成果

1. L. Ma, Julian Day-Cooney, Omar Pedro Jaidar Benavides, Michael A. Muniak, Maozhen Qin, Jun B. Ding, Tianyi Mao, and Haining Zhong. Locomotion activates PKA in both direct and indirect pathway striatal projection neurons. Nature. 2022 Nov;611(7937):762-768. https://www.nature.com/articles/s41586-022-05407-4

2. L. Ma, B. C. Jongbloets, W. H. Xiong, J. B. Melander, M. Qin, T. J. Lameyer, M. F. Harrison, B. V. Zemelman, T. Mao and H. Zhong (2018). A Highly Sensitive A-Kinase Activity Reporter for Imaging Neuromodulatory Events in Awake Mice. Neuron* 99(4): 665-679 e665. https://www.sciencedirect.com/science/article/pii/S0896627318305944

3. Li, W., L. Ma, G. Yang and W. B. Gan (2017). REM sleep selectively prunes and maintains new synapses in development and learning. Nature Neuroscience 20(3): 427-437. (Co-first author) https://www.nature.com/articles/nn.4479

4. L. Ma, Q. Qiao, J. W. Tsai, G. Yang, W. Li and W. B. Gan (2016). Experience-dependent plasticity of dendritic spines of layer 2/3 pyramidal neurons in the mouse cortex. Developmental Neurobiology 76(3): 277-286.

5. B. C. Jongbloets, L. Ma, T. Mao and H. Zhong (2019). Visualizing Protein Kinase A Activity In Head-Fixed Behaving Mice Using In Vivo Two-Photon Fluorescence Lifetime Imaging Microscopy. J. Vis. Exp. (148), e59526, doi:10.3791/59526 (2019). (Co-first author).

6. L. Ma, BC Jongbloets, WH Xiong, H Zhong, T Mao (2019). Imaging neuromodulatory signaling events at single cell resolution in behaving animal. Microscopy and Microanalysis 25 (S2), 1130-1131

7. Q. Qiao, L. Ma, W. Li, J. W. Tsai, G. Yang and W. B. Gan (2016). Long-term stability of axonal boutons in the mouse barrel cortex. Developmental Neurobiology 76(3): 252-261. (Co-first author)

8. Yang, G., C. S. Lai, J. Cichon, L. Ma, W. Li and W. B. Gan (2014). Sleep promotes branch-specific formation of dendritic spines after learning. Science 344(6188): 1173-1178.

9. Q Qiao, C Wu, L. Ma, H Zhang, M Li, X Wu, WB Gan. Motor learning-induced new dendritic spines are preferentially involved in the learned task than existing spines. Cell Reports. 2022 Aug 16;40 (7), 111229

10. Zhong H, Ceballos CC, Massengill CI, Muniak MA, L. Ma, Qin M, Petrie SK, Mao T. High-fidelity, efficient, and reversible labeling of endogenous proteins using CRISPR-based designer exon insertion. eLife. 2021 Jun 8;10.

11. Bai Y, Li M, Zhou Y, L. Ma, Qiao Q, Hu W, Li W, Wills ZP, Gan WB. Abnormal dendritic calcium activity and synaptic depotentiation occur early in a mouse model of Alzheimer's disease. Molecular Neurodegeneration. 2017 Nov 14;12(1):86.

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师资队伍

教授（含特聘研究员）

3. Li, W., L. Ma, G. Yang and W. B. Gan (2017). REM sleep selectively prunes and maintains new synapses in development and learning. Nature Neuroscience 20(3): 427-437. (Co-first author) https://www.nature.com/articles/nn.4479

4. L. Ma, Q. Qiao, J. W. Tsai, G. Yang, W. Li and W. B. Gan (2016). Experience-dependent plasticity of dendritic spines of layer 2/3 pyramidal neurons in the mouse cortex. Developmental Neurobiology 76(3): 277-286.

5. B. C. Jongbloets, L. Ma, T. Mao and H. Zhong (2019). Visualizing Protein Kinase A Activity In Head-Fixed Behaving Mice Using In Vivo Two-Photon Fluorescence Lifetime Imaging Microscopy. J. Vis. Exp. (148), e59526, doi:10.3791/59526 (2019). (Co-first author).

6. L. Ma, BC Jongbloets, WH Xiong, H Zhong, T Mao (2019). Imaging neuromodulatory signaling events at single cell resolution in behaving animal. Microscopy and Microanalysis 25 (S2), 1130-1131

7. Q. Qiao, L. Ma, W. Li, J. W. Tsai, G. Yang and W. B. Gan (2016). Long-term stability of axonal boutons in the mouse barrel cortex. Developmental Neurobiology 76(3): 252-261. (Co-first author)

8. Yang, G., C. S. Lai, J. Cichon, L. Ma, W. Li and W. B. Gan (2014). Sleep promotes branch-specific formation of dendritic spines after learning. Science 344(6188): 1173-1178.

9. Q Qiao, C Wu, L. Ma, H Zhang, M Li, X Wu, WB Gan. Motor learning-induced new dendritic spines are preferentially involved in the learned task than existing spines. Cell Reports. 2022 Aug 16;40 (7), 111229

10. Zhong H, Ceballos CC, Massengill CI, Muniak MA, L. Ma, Qin M, Petrie SK, Mao T. High-fidelity, efficient, and reversible labeling of endogenous proteins using CRISPR-based designer exon insertion. eLife. 2021 Jun 8;10.

11. Bai Y, Li M, Zhou Y, L. Ma, Qiao Q, Hu W, Li W, Wills ZP, Gan WB. Abnormal dendritic calcium activity and synaptic depotentiation occur early in a mouse model of Alzheimer's disease. Molecular Neurodegeneration. 2017 Nov 14;12(1):86.

快捷通道

师资队伍

教授（含特聘研究员）

3. Li, W*., L. Ma*, G. Yang and W. B. Gan (2017). REM sleep selectively prunes and maintains new synapses in development and learning. Nature Neuroscience 20(3): 427-437. (Co-first author) https://www.nature.com/articles/nn.4479

4. L. Ma*, Q. Qiao*, J. W. Tsai, G. Yang, W. Li and W. B. Gan (2016). Experience-dependent plasticity of dendritic spines of layer 2/3 pyramidal neurons in the mouse cortex. Developmental Neurobiology 76(3): 277-286.

5. B. C. Jongbloets*, L. Ma*, T. Mao and H. Zhong (2019). Visualizing Protein Kinase A Activity In Head-Fixed Behaving Mice Using In Vivo Two-Photon Fluorescence Lifetime Imaging Microscopy. J. Vis. Exp. (148), e59526, doi:10.3791/59526 (2019). (Co-first author).

6. L. Ma, BC Jongbloets, WH Xiong, H Zhong, T Mao (2019). Imaging neuromodulatory signaling events at single cell resolution in behaving animal. Microscopy and Microanalysis 25 (S2), 1130-1131

7. Q. Qiao*, L. Ma*, W. Li, J. W. Tsai, G. Yang and W. B. Gan (2016). Long-term stability of axonal boutons in the mouse barrel cortex. Developmental Neurobiology 76(3): 252-261. (Co-first author)

8. Yang, G., C. S. Lai, J. Cichon, L. Ma, W. Li and W. B. Gan (2014). Sleep promotes branch-specific formation of dendritic spines after learning. Science 344(6188): 1173-1178.

9. Q Qiao, C Wu, L. Ma, H Zhang, M Li, X Wu, WB Gan. Motor learning-induced new dendritic spines are preferentially involved in the learned task than existing spines. Cell Reports. 2022 Aug 16;40 (7), 111229

10. Zhong H, Ceballos CC, Massengill CI, Muniak MA, L. Ma, Qin M, Petrie SK, Mao T. High-fidelity, efficient, and reversible labeling of endogenous proteins using CRISPR-based designer exon insertion. eLife. 2021 Jun 8;10.

11. Bai Y, Li M, Zhou Y, L. Ma, Qiao Q, Hu W, Li W, Wills ZP, Gan WB. Abnormal dendritic calcium activity and synaptic depotentiation occur early in a mouse model of Alzheimer's disease. Molecular Neurodegeneration. 2017 Nov 14;12(1):86.

快捷通道

3. Li, W., L. Ma, G. Yang and W. B. Gan (2017). REM sleep selectively prunes and maintains new synapses in development and learning. Nature Neuroscience 20(3): 427-437. (Co-first author) https://www.nature.com/articles/nn.4479

4. L. Ma, Q. Qiao, J. W. Tsai, G. Yang, W. Li and W. B. Gan (2016). Experience-dependent plasticity of dendritic spines of layer 2/3 pyramidal neurons in the mouse cortex. Developmental Neurobiology 76(3): 277-286.

5. B. C. Jongbloets, L. Ma, T. Mao and H. Zhong (2019). Visualizing Protein Kinase A Activity In Head-Fixed Behaving Mice Using In Vivo Two-Photon Fluorescence Lifetime Imaging Microscopy. J. Vis. Exp. (148), e59526, doi:10.3791/59526 (2019). (Co-first author).

7. Q. Qiao, L. Ma, W. Li, J. W. Tsai, G. Yang and W. B. Gan (2016). Long-term stability of axonal boutons in the mouse barrel cortex. Developmental Neurobiology 76(3): 252-261. (Co-first author)