生物技术与生物制药；衰老的分子生物学

1. 国家自然科学基金，S100A6/CacyBP介导蛋白质稳态调控的机制及其在治疗阿尔茨海默病中的研究，负责人

2. 国家自然科学基金，多肽SNP-9靶向调控CacyBP对阿尔茨海默病tau蛋白病变的作用及机理，负责人

3. 国家自然科学基金，ERK1/2介导糖基转移酶GnT-III调控内质网稳态在AD中作用及机理，负责人

4. 国家自然科学基金，受体N-糖链对GLP-1防治糖尿病认知障碍的影响及机制，负责人

5. 国家自然科学基金，GLP-1受体介导的GSK-3β/PP2A平衡在糖尿病合并AD治疗中的作用及其机制研究，负责人

6. 企业合作项目，基于中国人群的肝癌共享新生抗原库的建立及治疗性疫苗研究，负责人

7. “重大新药创制”科技重大专项，治疗非酒精性脂肪性肝炎新型生物药PsTag600-FGF21的研发，负责人

8. “重大新药创制”科技重大专项，基于成药性的均一多糖药物制备及质量控制关键技术研究，负责人

9. 国家863项目，Ⅰ类抗肿瘤新药真菌多糖YCP的临床前研究，负责人

10. 国家自然科学基金，海洋真菌多糖YCP的免疫受体分析及作用机制研究，负责人

1. Jun Yin#, Qun Wang#, Shan Hou, Lichen Bao, Wenbing Yao*, Xiangdong Gao*. Potent Protein Delivery into Mammalian Cells via a Supercharged Polypeptide. Journal of the American Chemical Society, 2018, 140(49): 17234–17240.

2.  Yifan Yang#, Haichao Zhu#, Dingkang Liu, Hong Luo, Ruilong Chang, Yue Ji, Wenbing Yao*, Jun Yin*, Xiangdong Gao*. A Versatile Platform for the Tumor-Targeted Intracellular Delivery of Peptides, Proteins, and siRNA. Advanced Functional Materials, 2023, 2301011.

3. Dingkang Liu, Haibo Rong, Ye Chen, Qun Wang, Sijia Qian, Yue Ji, Wenbing Yao*, Jun Yin*, Xiangdong Gao*，Targeted disruption of mitochondria potently reverses multidrug resistance in cancer therapy. British Journal Of Pharmacology，2022, 179, 3346–3362

4. Siyuan Yao, Jiafan Wang, Zheng Xu, Yue Meng, Yue Xue, Fan Yang, Wenbing Yao*, Xiangdong Gao*, Song Chen*. A peptide rich in glycine-serine-alanine repeats ameliorates Alzheimer-type neurodegeneration. British Journal of Pharmacology. 2023, 180, 1878–1896

5. Song Chen#, Suting Chen#, Yan Sun, Zheng Xu, Ying Wang, Siyuan Yao, Wenbing Yao*, Xiangdong Gao*. Fibroblast growth factor 21 ameliorates neurodegeneration in rat and cellular models of Alzheimer’s disease. Redox Biology，2019,22: 101133. 

6. Dingkang Liu#, Lichen Bao#, Haichao Zhu, Yali Yue, Jing Tian, Xiangdong Gao*, Jun Yin*. Microenvironment-responsive anti-PD-L1 x CD3 bispecific T-cell engager for solid tumor immunotherapy. Journal Of Controlled Release. 2023, 354, 606–614

7. Lichen Bao#,, Jun Yin#,, Wen Gao, Qun Wang, Wenbing Yao*, Xiangdong Gao*. A long-acting FGF21 alleviates hepatic steatosis and inflammation in a mouse model of non-alcoholic steatohepatitis partly through an FGF21-adiponectin-IL17A pathway. British journal of pharmacology, 2018, 175(16):3379-3393. 

8. We Liu i#,, Xing Lv #, Wenhua Huang, Wenbing Yao *, Xiangdong Gao*. Characterization and hypoglycemic effect of a neutral polysaccharide extracted from the residue of Codonopsis Pilosula. Carbohydrate Polymers, 2018, 197:215-226. 

9. Yameng Liu#,, Wei Liu#,, Jing Li, Shuai Tang, Majie Wang, Wenhua Huang, Wenbing Yao*, Xiangdong Gao*. A polysaccharide extracted from Astragalus membranaceus residue improves cognitive dysfunction by altering gut microbiota in diabetic mice. Carbohydrate Polymers, 2019,205:500-512.

10. Jun Yin#,, Dingkang#, Liu, Lichen Bao, Qun Wang, Ye Chen, Shan Hou, Yali Yue, Wenbing Yao*, Xiangdong Gao*. Tumor targeting and microenvironment-responsive multifunctional fusion protein for pro-apoptotic peptide delivery. Cancer letters, 2019,452:38-50.