2012年博士毕业于南京大学,现为中国药科大学生命科学与技术学院副教授,博士生导师,中国病理生理学会肾脏病专业委员会青年委员、江苏省免疫学会基础免疫专业委员会委员,入选江苏省优秀青年基金、江苏省“六大人才高峰”人才项目,长期从事肾脏疾病的发病机理及肾脏疾病诊断服务和产品的研发。迄今在Nature communication、Nucleic Acids Res、J AM SOC NEPHROL、Cell Res、J Immunol和Cancer Res等杂志发表论文40余篇,单篇最高引用400余次。
肾脏病与免疫 |
1. 国家自然科学基金面上项目,32170897,信号调节蛋白α介导足细胞抗原递呈在足细胞损伤中的作用和机制研究,2022/01-2025/12,58万元,在研,主持
2. 企业合作项目,基于尿液囊泡蛋白标志物的糖尿病肾病诊断技术开发,2023/12-2025/01,50万元,在研,主持
3. 国家自然科学基金面上项目,31670917,B7-H4作为单核细胞型MDSC功能性表面标志物的研究,2017/01-2020/12,60万元,已结题,主持
4. 江苏省优秀青年科学基金项目,BK20170076,肝细胞核miR-122调控机制的研究,2017/07-2020/06,50万元,已结题,主持
5. 国家自然科学青年基金,31301061、MiR-21和miR-155促进MDSC聚积和功能的作用及机制研究,2014/01-2016/12,23万元,已结题,主持
6. 江苏省自然科学基金青年基金,BK20130564,Importin-8介导miRNA进核及功能的作用及机制研究,2013/07-2016/06,20万元,已结题,主持
7. 国家重点基础研究发展计划(973计划),2012CB517603, miRNA导致肾小球损伤的机制研究,2012/01-2016/12,340万元,已结题,参加
1. Polynucleotide phosphorylase protects against renal tubular injury via blocking mt-dsRNA-PKR-eIF2α axis. Zhu Y, Zhang M, Wang W, Qu S, Liu M, Rong W, Yang W, Liang H, Zeng C, Zhu X, Li L*, Liu Z*, Zen K*. Nat Commun. 2023, 14(1).
2. Complement induces podocyte pyroptosis in membranous nephropathy by mediating mitochondrial dysfunction. Wang H, Lv D, Jiang S, Hou Q, Zhang L, Li S, Zhu X, Xu X, Wen J, Zeng C, Zhang M, Yang F, Chen Z, Zheng C, Li J, Zen K, Liu Z*, Li L*. Cell Death Dis, 2022, 13(3)
3. Signal regulatory protein α protects podocytes through promoting autophagic activity. Li L#, Liu Y#, Li S#, Yang Y, Zeng C, Rong W, Liang H, Zhang M, Zhu X, Kidder K, Liu Y, Liu Z, Zen K. JCI Insight. 2019 Mar 19;5.
4. HIF-1α-induced miR-23a∼27a∼24 cluster promotes colorectal cancer progression via reprogramming metabolism. Jin F#, Yang R#, Wei Y#, Wang D, Zhu Y, Wang X, Lu Y, Wang Y*, Zen K*, Li L*. Cancer Lett. 2019 Jan;440-441:211-222.
5. Nuclear miR-122 directly regulates the biogenesis of cell survival oncomiR miR-21 at the posttranscriptional level. Wang D#, Sun X#, Wei Y#, Liang H, Yuan M, Jin F, Chen X, Liu Y, Zhang CY*, Li L*, Zen K*. Nucleic Acids Res. 2018 Feb 28;46(4):2012-2029.
6. MiR-26 enhances chemosensitivity and promotes apoptosis of hepatocellular carcinoma cells through inhibiting autophagy. Jin F#, Wang Y#, Li M, Zhu Y, Liang H, Wang C, Wang F, Zhang CY*, Zen K*, Li L*. Cell Death Dis. 2017 Jan 12;8(1):e2540.
7. Role of Myeloid-Derived Suppressor Cells in Glucocorticoid-Mediated Amelioration of FSGS. Li L#, Zhang T#, Diao W#, Jin F#, Shi L, Meng J, Liu H, Zhang J, Zeng CH, Zhang MC, Liang S, Liu Y, Zhang CY*, Liu Z*, Zen K*. J Am Soc Nephrol. 2015 Sep;26(9):2183-97.
8. The protective role of myeloid-derived suppressor cells in concanavalin A-induced hepatic injury. Diao W, Jin F, Wang B, Zhang CY, Chen J*, Zen K*, Li L*. Protein Cell. 2014 Sep; 5(9):714-24. doi: 10.1007/s13238-014-0069-5. Epub 2014 Jul 1.
9. Mouse miRNA-709 directly regulates miRNA-15a/16-1 biogenesis at the posttranscriptional level in the nucleus: evidence for a microRNA hierarchy system.Tang R#, Li L#, Zhu D, Hou D, Cao T, Gu H, Zhang J, Chen J*, Zhang CY*, Zen K*. Cell Res. 2012 Mar; 22(3):504-15. doi: 10.1038/cr.2011.137. Epub 2011 Aug 23.
10. Serum microRNA profiles serve as novel biomarkers for HBV infection and diagnosis of HBV-positive hepatocarcinoma. Li LM#, Hu ZB#, Zhou ZX#, Chen X, Liu FY, Zhang JF, Shen HB*, Zhang CY*, Zen K*. Cancer Res. 2010 Dec 1;70(23):9798-807. doi: 10.1158/0008-5472.CAN-10-1001. Epub 2010 Nov 23. Erratum in: Cancer Res. 2011 Mar 1; 71(5):2022.