刘玮，女，博士，副教授，江苏徐州人。曾赴美国北卡罗来纳大学药学院、美国马里兰大学药学院访学。科研方向为糖类创新药物及活体生物药的研发，主持国家自然科学基金2项，国家重点研发计划子课题子任务1项，省级项目6项，参与多项重大新药创制、863等项目，发表SCI论文50余篇，授权专利5项，在糖类药物的合成及构建、结构解析、质量控制、功能评价、糖生物工程应用、肠道菌的基因工程改造等方面积累了丰富的经验。入选江苏省六大高峰人才，江苏省青蓝工程”优秀青年骨干教师计划。
| 生物大分子的结构与功能 |
1、 国家重点研发计划，基于成药性特征的微生物天然产物合成生物学创制，科技部，子课题子任务负责人，2018YFA0902000，2019.7-2024.6，经费104.6万元；
2、 国家自然科学基金面上项目，基于糖组解码和谱效关系的肿节风糖类特征标识研究及在质控中的应用，81673589, 2017.1-2020.12，经费52万元；
3、 国家自然科学基金青年基金，基于结构特征的枸杞多糖多元指纹图谱体系的构建及应用，31301473，2014.1-2016.12，经费24万元；
4、 江苏省自然科学基金面上项目，基于糖链编辑及遗传密码扩增的蛋白聚糖的分子构建及评价，BK20191317，2019.7-2022.6，经费10万元；
5、 企业横向项目，枸杞多糖中糖类检测方法的建立及方法学验证，2023.10-2024.10，经费15万元。
1. Cai Yang1, Si Zhenyuan1, Jiang Ying,Ye Meng, Wang Feng, Yang Xiaobing, Yu Juping*, Gao Xiangdong**, Liu Wei***. Structure-activity relationship of low molecular Astragalus membranaceus polysaccharides produced by Bacteroides. Carbohydrate polymers. 2023,121036, 316C.
2. Si Zhenyuan1, Cai Yang1, Zhao Lang, Han Lu, Wang Feng, Yang Xiaobing, Gao Xiangdong*, Meiling Lu**, and Liu Wei***. Structure and function characterization of the α-L-arabinofuranosidase from the white-rot fungus Trametes hirsuta.Applied Microbiology and Biotechnology. 2023, 107, 3967-3981.
3. Ye Meng, Feng Qi, Jiang Ying, Wang Feng, Shi Xuexia, Yang Xiaobing, Gao Xiangdong *, and Liu Wei **. Structure characterization and anti-rheumatoid arthritis activity of a polysaccharide from Notopterygium incisum. Molecular Nutrition and Food Research,2023, 67(15):2200713.
4. Feng Qi 1, Si Yu 1, Zhu Lingling, Wang Feng, Fang Junqiang, Pan Chun, Gao Xiangdong *, Liu Wei **. Anti-inflammatory effects of a SERP 30 polysaccharide from the residue of Sarcandra glabra against lipopolysaccharide-induced acute respiratory distress syndrome in mice, Journal of Ethnopharmacology, 2022, 293,115262.
5. Yu Juping 1, Ye Meng 1, Li Kaidong, Wang Feng, Shi Xuexia , Pan Chun, Yang Xiaobing, Gao Xiangdong *, Liu Wei **. Fragments of a pectin from Arctium lappa L: Molecular properties and intestinal regulation activity. Journal of Functional Food, 2022, 88, 104900.
6. Liu Wei 1, Gong Xingqun1, Luo Jianhua, Jiang Liangliang, Lu Weisheng, Pan Chun, Yao Wenbing, Gao Xiangdong*, Tian Hong **. A purified acidic polysaccharide from Sarcandra glabra as vaccine adjuvant to enhance anti-tumor effect of cancer vaccine. Carbohydrate Polymers, 2021, 263, 117967.
7. Tang Shuai 1, Liu Wei 1, Zhao Qianqian, Li Kaidong, Zhu Jingyi, Yao Wenbing *, Gao Xiangdong **, Combination of polysaccharides from Astragalus membranaceus and Codonopsis pilosula ameliorated mice colitis and underlying mechanisms. Journal of Ethnopharmacology, 2021, 264, 113280.
8. Ye Meng, Yu Juping, Shi Xuexia, Zhu Jingyi, Gao Xiangdong*, Liu Wei **. Polysaccharide catabolism by the human gut bacterium-Bacteroides thetaiotaomicron: advances and perspectives. Critical Reviews in Food Science and Nutrition,2021, 61(21):3569-3588.
9. Sun Xuyang, Zhao Qianqian, Si Yu, Li Kaidong, Zhu Jingyi, Gao Xiangdong*, Liu Wei **. Bioactive structural basis of proteoglycans from Sarcandra glabra based on spectrum-effect relationship. Journal of Ethnopharmacology, 2020, 259, 112941.
10. Liu Wei 1, Tang Shuai1, Zhao Qianqian, Zhang Wanyue, Li Kaidong, Yao Wenbing*, Gao Xiangdong **. The α-D-glucan from marine fungus Phoma herbarum YS4108 ameliorated mice colitis by repairing mucosal barrier and maintaining intestinal homeostasis. International Journal of Biological Macromolecules. 2020,149: 1180-1188.
