1. Luting Yu, Yihan Zhou, Shaozheng Sun, Runlin Wang, Weihong Yu, Hanyu Xiao, Zhuxi Yu*, Chen Luo*. Tumor-suppressive effect of Reg3A in COAD is mediated by T cell activation in nude mice. Biomedicine & Pharmacotherapy, 2023, 169: 115922.
2. Luting Yu, Liang Li, Junli Liu, Hao Sun, Xiang Li, Hanyu Xiao, Martin Omondi Alfred, Min Wang, Xuri Wu, Yan Gao*, Chen Luo*; Recombinant Reg3α Prevents Islet β-Cell Apoptosis and Promotes β-Cell Regeneration. International Journal of Molecular Sciences, 2022, 23(18): 10584.
3. Pei Du, Xiaonan Wang, Tianqi Yin, Xueqing Zhang, Zhiyuan Zhang, Weihong Yu, Min Wang, Chen Luo*, Luting Yu*. Anti-tumor effect of single-chain antibody to Reg3a in colorectal cancer. Experimental Cell Research, 2020, 396(1): 112278.
4. Yu, L., Li, X., Zhang, Z., Du, P., Liu, J. L., Li, Y., Yin, T., Yu, W., Sun, H., Wang, M., Luo, C*. Dimorphic autoantigenic and protective effects of Reg2 peptide in the treatment of diabetic beta-cell loss. Diabetes Obes Metab, 2019, 21(5): 1209.
5. Zhang, X. Q., Yu, L. T., Du, P., Yin, T. Q., Zhang, Z. Y., Xu, Y., Li, X., Li, Y. J., Wang, M.*, Luo, C.* Single-chain antibody against Reg4 suppresses gastric cancer cell growth and enhances 5-FU-induced cell death in vitro. Anticancer Agents Med Chem, 2018, 19(5): 610.
6. Yu, L. T.; Yang, M. Q.; Liu, J. L.; Alfred, M. O.; Li, X.; Zhang, X. Q.; Zhang, J.; Wu, M. Y.; Wang, M.*; Luo, C.*. Recombinant Reg3alpha protein protects against experimental acute pancreatitis in mice. Mol Cell Endocrinol, 2016, 422: 150.
7. Chen Luo, Lu-Ting Yu, Meng-Qi Yang, Xiang Li, Zhi-Yuan Zhang, Martin O Alfred, Jun-Li Liu* & Min Wang*. Recombinant Reg3β protein protects against streptozotocin induced β-cell damage and diabetes. Scientific Reports, 2016, 10.1038/srep35640.
8. Luo Y, Yu L, Yu T, Jiang F, Cai X, Zhao Y, Pan S*, Luo C*. The association of DNA methyltransferase 1 gene polymorphisms with susceptibility to childhood acute lymphoblastic leukemia. Biomed Pharmacother, 2015, 73: 35.
9. Luo C, Li B, Liu L, Yin HP, Wang M*, Liu JL*. Transcriptional activation of Reg2 and Reg3β genes by glucocorticoids and interleukin-6 in pancreatic acinar and islet cells. Mol Cell Endocrinol, 2013, 365(2): 187.
10. 罗晨, 张东文, 周艺涵, 庾璐婷, 封颖, 徐可奕, 李昕. 一对RegⅣ单链抗体及其含有该抗体试剂盒和检测方法. 2023, 中国专利, 申请号: 2023100573337.
| 糖尿病胰岛损伤与再生 |
1. 人源Reg2蛋白单链抗体制备和血清ELSIA方法建立，横向项目，2024-01-01，进行中，主持
2. 人源Reg3A和Reg4蛋白单链抗体制备，横向项目，2023-05-23，进行中，主持
3. 基于Reg家族蛋白的糖尿病早期筛查与发病治疗关键技术研究，纵向项目，2023-01-01，进行中，厅局级，主持
4. Reg2蛋白促进去分化β细胞再成熟的作用和机制研究，纵向项目，2022-01-01，进行中，国家级，主持
5. Reg3α促腺泡细胞向胰岛素分泌细胞转化再生治疗糖尿病的作用和机制研究，纵向项目，2017-01-01，已结题，国家级，主持
6. 重组Reg蛋白促胰岛β细胞增殖、抗凋亡作用及其机制的研究，纵向项目，2013-07-01，已结题，省部级，主持
1. Luting Yu, Yihan Zhou, Shaozheng Sun, Runlin Wang, Weihong Yu, Hanyu Xiao, Zhuxi Yu*, Chen Luo*. Tumor-suppressive effect of Reg3A in COAD is mediated by T cell activation in nude mice. Biomedicine & Pharmacotherapy, 2023, 169: 115922.
2. Luting Yu, Liang Li, Junli Liu, Hao Sun, Xiang Li, Hanyu Xiao, Martin Omondi Alfred, Min Wang, Xuri Wu, Yan Gao*, Chen Luo*; Recombinant Reg3α Prevents Islet β-Cell Apoptosis and Promotes β-Cell Regeneration. International Journal of Molecular Sciences, 2022, 23(18): 10584.
3. Pei Du, Xiaonan Wang, Tianqi Yin, Xueqing Zhang, Zhiyuan Zhang, Weihong Yu, Min Wang, Chen Luo*, Luting Yu*. Anti-tumor effect of single-chain antibody to Reg3a in colorectal cancer. Experimental Cell Research, 2020, 396(1): 112278.
4. Yu, L., Li, X., Zhang, Z., Du, P., Liu, J. L., Li, Y., Yin, T., Yu, W., Sun, H., Wang, M., Luo, C*. Dimorphic autoantigenic and protective effects of Reg2 peptide in the treatment of diabetic beta-cell loss. Diabetes Obes Metab, 2019, 21(5): 1209.
5. Zhang, X. Q., Yu, L. T., Du, P., Yin, T. Q., Zhang, Z. Y., Xu, Y., Li, X., Li, Y. J., Wang, M.*, Luo, C.* Single-chain antibody against Reg4 suppresses gastric cancer cell growth and enhances 5-FU-induced cell death in vitro. Anticancer Agents Med Chem, 2018, 19(5): 610.
6. Yu, L. T.; Yang, M. Q.; Liu, J. L.; Alfred, M. O.; Li, X.; Zhang, X. Q.; Zhang, J.; Wu, M. Y.; Wang, M.*; Luo, C.*. Recombinant Reg3alpha protein protects against experimental acute pancreatitis in mice. Mol Cell Endocrinol, 2016, 422: 150.
7. Chen Luo, Lu-Ting Yu, Meng-Qi Yang, Xiang Li, Zhi-Yuan Zhang, Martin O Alfred, Jun-Li Liu* & Min Wang*. Recombinant Reg3β protein protects against streptozotocin induced β-cell damage and diabetes. Scientific Reports, 2016, 10.1038/srep35640.
8. Luo Y, Yu L, Yu T, Jiang F, Cai X, Zhao Y, Pan S*, Luo C*. The association of DNA methyltransferase 1 gene polymorphisms with susceptibility to childhood acute lymphoblastic leukemia. Biomed Pharmacother, 2015, 73: 35.
9. Luo C, Li B, Liu L, Yin HP, Wang M*, Liu JL*. Transcriptional activation of Reg2 and Reg3β genes by glucocorticoids and interleukin-6 in pancreatic acinar and islet cells. Mol Cell Endocrinol, 2013, 365(2): 187.
10. 罗晨, 张东文, 周艺涵, 庾璐婷, 封颖, 徐可奕, 李昕. 一对RegⅣ单链抗体及其含有该抗体试剂盒和检测方法. 2023, 中国专利, 申请号: 2023100573337.
