纳米药物、新型疫苗佐剂、蛋白多肽类药物及其复杂制剂方面的开发研究 |
纳米药物、新型疫苗佐剂、蛋白多肽类药物及其复杂制剂方面的开发研究 |
1. 江苏省自然科学基金青年项目,BK20160757,一种靶向基质金属蛋白酶9的纳米诊疗探针的研究
2. 江苏省自然科学基金青年项目,BK20210981,鲍曼不动杆菌纳米疫苗Chitosan-PLGA-rOmp22的粘膜免疫效应及其机制研究
3. 江苏省农业科技自主创新资金项目,CX(19)2014,噬菌体裂解酶源新型生物饲料添加剂的开发
4. 国家自然科学基金面上项目,81773028,原癌基因SET在雌激素诱导的基因转录激活中的功能和作用机制
5. 国家重大新药创制科技重大专项:抗肿瘤I类新药多肽AP25的临床前研究及I期临床试验开展(2019ZX09301-110)
6. 国家自然科学基金面上项目,81671803,基于深部肿瘤渗透的新策略高效构建肿瘤靶向治疗的仿生纳米细胞传递系统
代表性论文:
[1] Du X#, Xue J#, Jiang M, et al. A Multi-epitope Peptide rOmp22 Encapsulated in Chitosan-PLGA Nanoparticles as Vaccine Candidate Against Acinetobacter baumannii Infection. International Journal of Nanomedicine, 2021, 16: 1819-1836 (IF=5.115, 共一作者)
[2] Yang P, Wang Y, Yao Z, Gao X, Liu C, Wang X, Wu H, Ding X, Hu J, Lin B, Li Q, Li M, Li X, Chen X, Qi W, Li W, Xue J*, Xu H*. Enhanced Safety and Antitumor Efficacy of Switchable Dual Chimeric Antigen Receptor-Engineered T Cells against Solid Tumors through a Synthetic Bifunctional PD-L1-Blocking Peptide. J Am Chem Soc. 2020, 142(44):18874-18885. (IF=14.62,共通讯)
[3] Li W, Xue J, Xu H*. Combined administration of PTX and S-HM-3 in TPGS/Solutol micelle system for oncotarget therapy. International Journal of Nanomedicine, 2019, 14: 1011-1026. (IF=4.37)
[4] Zhang E, Gu J, Xue J, et al. Accurate control of dual-receptor-engineered T cell activity through a bifunctional anti-angiogenic peptide. Journal of hematology & oncology, 2018, 1(1): 44. (IF=7.33)
[5] Jianpeng Xue, Lingling Shan, Haiyan Chen, Yang Li, Hongyan Zhu, Dawei Deng, Zhiyu Qian, Samuel Achilefu, Yueqing Gu. Visual detection of STAT5B gene expression in living cell using the hairpin DNA modified gold nanoparticle beacon. Biosens Bioelectron. 2013, 41:71-77. (IF=5.437)
[6] Tang Rui, Xue Jianpeng, Xu Baogang, Shen Danwen, Sudlow Gail, Achilefu Samuel. Tunable Ultrasmall Visible-to-Extended Near-Infrared Emitting Silver Sulfide Quantum Dots for Integrin-Targeted Cancer Imaging. ACS Nano. 2015, 9(1):220-30. (IF=12.033)
代表性专著:
1. (美)亚当斯·I·莱文(Adam I.Levine) 主编; 吕建平 主译,《模拟医学》(第三部分 模拟在医学各学科中的应用, 第1章 模拟在麻醉学中的应用-薛建鹏译),人民卫生出版社, 2017年。
2. 徐寒梅主编《新药非临床研究与开发》(薛建鹏 执行主编),中国医药科技出版社,2020年。
3. Laura A. Sordillo and Peter P. Sordillo 主编,《Biophotonics, Tryptophan and Disease》(Chapter 15 Tryptophan fluorescence and machine learning to study the aggressiveness of prostate cancer cell lines: A pilot study,Jianpeng Xue, Haiding Mo, Yuke Tian, Rui Tang, and Binlin Wu),Copyright © 2022 Elsevier Inc. All rights reserved.2021,ISBN:978-0-12-822790-9,https://doi.org/10.1016/C2019-0-04827-3