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刘畅
职称:教授
邮箱:changliu@cpu.edu.cn
学院:生命科学与技术学院
实验室:江宁校区教学楼B207室
招生学科:生物学,微生物与生化药学
办公室:江宁校区教学楼B207室
个人简历

1. Sun C, Liang J, Zheng J, Mao S, Chen S, Aikemu A, Liu C*. Brown adipose Vanin-1 is required for the maintenance of mitochondrial homeostasis and prevents diet-induced metabolic dysfunction. Molecular Metabolism (2024), in press.

2. Chen S, Zhang W, Li X, Cao Z, Liu C*. DNA polymerase beta connects tumorigenicity with the circadian clock in liver cancer through the epigenetic demethylation of Per1. Cell Death and Disease (2024), 15(1): 78.

3. Song M, Zhu B, Qiu S, Tian J, Li J, Chen D, Liu C*. Codelivery of afuresertib and celecoxib by IL4RPep-1-targeting nanoparticles for effective treatment against melanoma. Applied Materials Today. (2023) 33, 101868.

4. Zhang S, Xu M, Shen Z, Shang C, Zhang W, Chen S, Liu C*. Green light exposure aggravates high-fat diet feeding-induced hepatic steatosis and pancreatic dysfunction in male mice. Ecotoxicology and Environmental Safety (2021), 225(16): 112802-12.

5. Chen S, Zhang W, Sun C, Song M, Liu S, Xu M, Zhang X, Liu L, Liu C*. Systemic nanoparticle-mediated delivery of pantetheinase Vanin-1 regulates lipolysis and adiposity in abdominal white adipose tissue. Advanced Science (2020), 7(14): 2000542.

6. Rabearivony A, Li H, Zhang S, Chen S, An X, Liu C*. Housing temperature affects the circadian rhythm of hepatic metabolism and clock genes. Journal of Endocrinology (2020), 247(2): 183-195.

7. Chen S, Feng M, Zhang S, Dong Z, Wang Y, Zhang W, Liu C*. Angptl8 mediates food-driven resetting of hepatic circadian clock in mice. Nature Communications (2019), 10: 3518.

8. Zhang S, Zhang Y, Zhang W, Chen S, Liu C*. Chronic exposure to green light aggravates high-fat diet-induced obesity and metabolic disorders in male mice. Ecotoxicology and Environmental Safety (2019), 178: 94-104.

研究方向

能量代谢调控与靶向药物开发

主持在研项目情况

国家重点研发计划子课题2021YFF0702000):基于新靶点的重大传染病人源化动物模型研发, 2021-2025资助金额80万元。

国家自然科学基金重大研究计划培育项目(编号92057112):HlncRNA-1整合肝脏生物钟和糖脂代谢的分子机制研究,2021-2023,资助金额81万元。

国家自然科学基金面上项目(编号31771298):肝源因子Betatrophin重设肝脏生物时钟的分子机制研究,2018-2021,资助金额60万元。

基金委优秀青年科学基金项目(编号31422028):能量代谢的分子调控机制,2015-2017,资助金额100万元。

中央组织部青年拔尖人才计划项目,2013-2015,资助金额240万元。

科技部973重大研究计划项目子课题生物钟在发育中的调节机制(编号2012CB947601),2012-2016,资助金额180万元。

江苏省杰出青年基金项目(编号BK20140041):能量代谢性疾病的分子病理学,2014-2016,资助金额100万元。

国家自然科学基金面上项目(编号31271261):高血脂通过抑制Smarcd1损害血管平滑肌细胞生物时钟和生理稳态的分子机制,2013-2016,资助金额80万元。

近年代表性科研成果

1. Sun C, Liang J, Zheng J, Mao S, Chen S, Aikemu A, Liu C*. Brown adipose Vanin-1 is required for the maintenance of mitochondrial homeostasis and prevents diet-induced metabolic dysfunction. Molecular Metabolism (2024), in press.

2. Chen S, Zhang W, Li X, Cao Z, Liu C*. DNA polymerase beta connects tumorigenicity with the circadian clock in liver cancer through the epigenetic demethylation of Per1. Cell Death and Disease (2024), 15(1): 78.

3. Song M, Zhu B, Qiu S, Tian J, Li J, Chen D, Liu C*. Codelivery of afuresertib and celecoxib by IL4RPep-1-targeting nanoparticles for effective treatment against melanoma. Applied Materials Today. (2023) 33, 101868.

4. Zhang S, Xu M, Shen Z, Shang C, Zhang W, Chen S, Liu C*. Green light exposure aggravates high-fat diet feeding-induced hepatic steatosis and pancreatic dysfunction in male mice. Ecotoxicology and Environmental Safety (2021), 225(16): 112802-12.

5. Chen S, Zhang W, Sun C, Song M, Liu S, Xu M, Zhang X, Liu L, Liu C*. Systemic nanoparticle-mediated delivery of pantetheinase Vanin-1 regulates lipolysis and adiposity in abdominal white adipose tissue. Advanced Science (2020), 7(14): 2000542.

6. Rabearivony A, Li H, Zhang S, Chen S, An X, Liu C*. Housing temperature affects the circadian rhythm of hepatic metabolism and clock genes. Journal of Endocrinology (2020), 247(2): 183-195.

7. Chen S, Feng M, Zhang S, Dong Z, Wang Y, Zhang W, Liu C*. Angptl8 mediates food-driven resetting of hepatic circadian clock in mice. Nature Communications (2019), 10: 3518.

8. Zhang S, Zhang Y, Zhang W, Chen S, Liu C*. Chronic exposure to green light aggravates high-fat diet-induced obesity and metabolic disorders in male mice. Ecotoxicology and Environmental Safety (2019), 178: 94-104.