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欧瑜
职称:教授
邮箱:ouyu2008@126.com
学院:生命科学与技术学院
实验室:江宁校区学院实验楼一期322室
招生学科:微生物与生化药学,生物学,生物与医药
办公室:江宁校区学院实验楼一期333室
个人简历

1. Yunbiao Lu, Rongrong Huang, Zhongkan Sun, Yu Ou*. A bovine milk-derived peptide ameliorates pancreatic β-cell dedifferentiation through PI3K/Akt/FOXO1 signaling in type 2 diabetes. Food & Function, 2023, 14(17):8018-8029.

2. Peng Ma, Yu Ou*. Correlation between the dopaminergic system and inflammation disease: a review. Molecular Biology Reports, 2023, 50(8):7043-7053.

3. Peng Ma, Rongrong Huang, Yu Ou*. A soy glycinin derived octapeptide protects against MCD diet induced non-alcoholic fatty liver disease in mice. Food Science and Human Wellness, 2022, 011(006):1544-1554.

4. Rongrong Huang, Yunbiao Lu, Zhifei Xie, Xuegan Yang, Yu Ou*. A bovine milk-derived peptide ameliorates alloxan-injured pancreatic β cells through IRS2/PI3K/Akt signaling. Life Science. 2022, 308:120907.

5. Qihao Li, Wen Peng, Zhaoyu Zhang, Xin Pei, Zhongkan Sun, Yu Ou* . A phycocyanin derived eicosapeptide attenuates lung fibrosis development. European Journal Of Pharmacology, 2021, 908:174356.

6. Peng Ma, Rongrong Huang, Jingyao Jiang, Yuan Ding, Tingting Li, Yu Ou*. Potential Use of C-phycocyanin in Non-Alcoholic Fatty Liver Disease. Biochemical and Biophysical Research Communications, 2020, 526(4): 906-912.  

7. Zhiheng Ren, Zhifei Xie, Danni Cao, Mufeng Gong, Lei Yang, Zhu Zhou, Yu Ou *. C-Phycocyanin inhibits hepatic gluconeogenesis and increases glycogen synthesis via activating Akt and AMPK in insulin resistance hepatocytes. Food & Function, 2018, 23;9(5):2829-2839.

8. Gaoyong Liao, Bing Gao, Yingnv Gao, Xuegan Yang, Xiaodong ChengYu Ou*. Phycocyanin Inhibits Tumorigenic Potential of Pancreatic Cancer Cells: Role of Apoptosis and Autophagy. Scientific Reports, 2016, 6:34564.

9. Yingnv Gao, Gaoyong Liao, Chenxi Xiang, Xuegan Yang, Xiaodong Cheng*, Yu Ou*. Effects of Phycocyanin on INS-1 Pancreatic β-Cell Mediated by PI3K/Akt/FoxO1 signaling pathway. International Journal of Biological Macromolecules, 2016, 83: 185-194.

10. Yingnv Gao, Chen Liu, Guoqing Wan, Xinshuo Wang, Xiaodong Cheng, Yu Ou*. Phycocyanin prevents methylglyoxal-induced mitochondrial-dependent apoptosis in INS-1 cells by Nrf2. Food & Function, 2016, 7: 1129-1137.

 

研究方向

糖脂代谢

主持在研项目情况

重大新药创制专项:抗类风湿一类新药PEG-HM-3临床前研究

江苏省科技支撑计划-社会发展项目:降糖新药藻蓝蛋白的研究开发。

江苏省“六大人才高峰”人才项目:基于胰岛素信号转导通路探讨藻蓝蛋白抗2型糖尿病机制。

教育部重点项目:重组水蛭素Ⅲ防治糖性白内障的机制研究。

中央高校基本科研业务费专项资金重点基础研究项目:藻蓝蛋白治疗2型糖尿病作用机制的研究。

 

近年代表性科研成果

1. Yunbiao Lu, Rongrong Huang, Zhongkan Sun, Yu Ou*. A bovine milk-derived peptide ameliorates pancreatic β-cell dedifferentiation through PI3K/Akt/FOXO1 signaling in type 2 diabetes. Food & Function, 2023, 14(17):8018-8029.

2. Peng Ma, Yu Ou*. Correlation between the dopaminergic system and inflammation disease: a review. Molecular Biology Reports, 2023, 50(8):7043-7053.

3. Peng Ma, Rongrong Huang, Yu Ou*. A soy glycinin derived octapeptide protects against MCD diet induced non-alcoholic fatty liver disease in mice. Food Science and Human Wellness, 2022, 011(006):1544-1554.

4. Rongrong Huang, Yunbiao Lu, Zhifei Xie, Xuegan Yang, Yu Ou*. A bovine milk-derived peptide ameliorates alloxan-injured pancreatic β cells through IRS2/PI3K/Akt signaling. Life Science. 2022, 308:120907.

5. Qihao Li, Wen Peng, Zhaoyu Zhang, Xin Pei, Zhongkan Sun, Yu Ou* . A phycocyanin derived eicosapeptide attenuates lung fibrosis development. European Journal Of Pharmacology, 2021, 908:174356.

6. Peng Ma, Rongrong Huang, Jingyao Jiang, Yuan Ding, Tingting Li, Yu Ou*. Potential Use of C-phycocyanin in Non-Alcoholic Fatty Liver Disease. Biochemical and Biophysical Research Communications, 2020, 526(4): 906-912.  

7. Zhiheng Ren, Zhifei Xie, Danni Cao, Mufeng Gong, Lei Yang, Zhu Zhou, Yu Ou *. C-Phycocyanin inhibits hepatic gluconeogenesis and increases glycogen synthesis via activating Akt and AMPK in insulin resistance hepatocytes. Food & Function, 2018, 23;9(5):2829-2839.

8. Gaoyong Liao, Bing Gao, Yingnv Gao, Xuegan Yang, Xiaodong ChengYu Ou*. Phycocyanin Inhibits Tumorigenic Potential of Pancreatic Cancer Cells: Role of Apoptosis and Autophagy. Scientific Reports, 2016, 6:34564.

9. Yingnv Gao, Gaoyong Liao, Chenxi Xiang, Xuegan Yang, Xiaodong Cheng*, Yu Ou*. Effects of Phycocyanin on INS-1 Pancreatic β-Cell Mediated by PI3K/Akt/FoxO1 signaling pathway. International Journal of Biological Macromolecules, 2016, 83: 185-194.

10. Yingnv Gao, Chen Liu, Guoqing Wan, Xinshuo Wang, Xiaodong Cheng, Yu Ou*. Phycocyanin prevents methylglyoxal-induced mitochondrial-dependent apoptosis in INS-1 cells by Nrf2. Food & Function, 2016, 7: 1129-1137.