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沈辉
职称:教授
邮箱:shhui@cpu.edu.cn
学院:生命科学与技术学院
实验室:江宁校区学院实验楼一期219室
招生学科:生物学,微生物与生化药学
办公室:江宁校区学院实验楼一期204室
个人简历

RNA enzymology

研究方向

RNA enzymology

主持在研项目情况

暂无

近年代表性科研成果

*一作

1. Gonskikh Y*, Stoute J*, Shen H*, Budinich K, Pingul B, Schultz K, Marmorstein R, Shi JW, Liu KF. Identification of an RNA-binding region in 18S dimethyladenosine methyltransferase DIMT1 essential for proliferation of acute myeloid leukemia cells. Genes & Dev (2023) 37(7-8):321-335.

2. Shen H*, Yanas A*, Owens MC, Zhang C, Fritsch C, Fare CM, Copley KE, Shorter J, Goldman YE, Liu KF. Sexually dimorphic RNA helicases DDX3X and DDX3Y differentially regulate RNA metabolism through phase separation. Mol Cell (2022) 82:1-16.

3. Shen H, Gonskikh Y, Stoute J, Liu KF. Human DIMT1 generates N26,6A-dimethylation-containing small RNAs. J Biol Chem (2021) 297(4):101146.

4. Shen H*, Ontiveros RJ*, Owens MC, Liu MY, Ghanty U, Kohli RM, Liu KF. TET-mediated 5-methylcytosine oxidation in tRNA promotes translation. J Biol Chem (2021) 296:100087.

5. Shen H, Stoute J, Liu KF. Structural and catalytic roles of the human 18S rRNA methyltransferases DIMT1 in ribosome assembly and translation. J Biol Chem (2020) 295(34):12058-12070.

6. Ontiveros RJ*, Shen H*, Stoute J, Yanas A, Cui YX, Zhang YY, Liu KF. Coordination of mRNA and tRNA methylations by TRMT10A. Proc Natl Acad Sci (2020) 117(14):7782-7791.

7. Yu SH*, Shen H*, Cheng YY, Zhu YY, Li X#, Mu WM#. Structural and functional basis of difructose anhydride III hydrolase, which sequentially converts inulin using the same catalytic residue. ACS Catal (2018) 8(11):10683-10697.

8. Shen H*, Zhu YW*, Wang CY, Yan H, Teng MK, Li X. Structural and histone binding ability characterization of the ARB2 domain of a histone deacetylase Hda1 from Saccharomyces cerevisiae. Sci Rep (2016) 6:33905. 

9. Shen H*, Wang H*, Liu Q, Teng MK, Li X. Structural insights into RNA recognition properties of glyceraldehyde-3-phosphate dehydrogenase 3 from Saccharomyces cerevisiae. IUBMB Life (2014) 66(9):631-638.

10. Shen H, Liu HH, Wang H, Teng MK, Li X. Preliminary crystallographic analysis of RraB from Escherichia coli. Acta Crystallogr. F (2013) 69:1268-1271.