1.探究腺苷的释放来源及其对动物行为的调控机制。

2.探究胆碱能神经元调节纹状体神经元PKA及动物行为的作用机制。

3.探究多巴胺缺失对纹状体神经元PKA的影响，并以此为依据，开发出以PKA为靶标来干预和治疗多巴胺紊乱相关疾病的新型策略。

4.探究睡眠剥夺后PKA的变化及其对学习记忆和情绪的影响。

1.中国国家博士后基金（主持）      2015M580920        11/05/2015 -06/01/2017  5万

2. 深圳市科技创新基金（主持）  JCYJ20160428154351820 睡眠期间钙离子树突峰电位对阿尔茨海默症发病进程的影响   06/23/2016–06/30/2018   40万                                 

3. 深圳市科技创新基金（主持） JCYJ20170807144417251学习过程中钙离子树突峰电位和新树突棘的相互关系研究     03/09/2018–03/31/2020   50万 

1. L. Ma, Julian Day-Cooney, Omar Pedro Jaidar Benavides, Michael A. Muniak, Maozhen Qin, Jun B. Ding, Tianyi Mao, and Haining Zhong. Locomotion activates PKA in both direct and indirect pathway striatal projection neurons. Nature. 2022 Nov;611(7937):762-768.   https://www.nature.com/articles/s41586-022-05407-4

2. L. Ma*, B. C. Jongbloets*, W. H. Xiong*, J. B. Melander, M. Qin, T. J. Lameyer, M. F. Harrison, B. V. Zemelman, T. Mao and H. Zhong (2018). A Highly Sensitive A-Kinase Activity Reporter for Imaging Neuromodulatory Events in Awake Mice. Neuron 99(4): 665-679 e665. https://www.sciencedirect.com/science/article/pii/S0896627318305944

3. Li, W*., L. Ma*, G. Yang and W. B. Gan (2017). REM sleep selectively prunes and maintains new synapses in development and learning. Nature Neuroscience 20(3): 427-437. (Co-first author) https://www.nature.com/articles/nn.4479

4. L. Ma*, Q. Qiao*, J. W. Tsai, G. Yang, W. Li and W. B. Gan (2016). Experience-dependent plasticity of dendritic spines of layer 2/3 pyramidal neurons in the mouse cortex. Developmental Neurobiology 76(3): 277-286.

5. B. C. Jongbloets*, L. Ma*, T. Mao and H. Zhong (2019). Visualizing Protein Kinase A Activity In Head-Fixed Behaving Mice Using In Vivo Two-Photon Fluorescence Lifetime Imaging Microscopy. J. Vis. Exp. (148), e59526, doi:10.3791/59526 (2019). (Co-first author).

6. L. Ma, BC Jongbloets, WH Xiong, H Zhong, T Mao (2019). Imaging neuromodulatory signaling events at single cell resolution in behaving animal. Microscopy and Microanalysis 25 (S2), 1130-1131

7. Q. Qiao*, L. Ma*, W. Li, J. W. Tsai, G. Yang and W. B. Gan (2016). Long-term stability of axonal boutons in the mouse barrel cortex. Developmental Neurobiology 76(3): 252-261. (Co-first author)

8. Yang, G., C. S. Lai, J. Cichon, L. Ma, W. Li and W. B. Gan (2014). Sleep promotes branch-specific formation of dendritic spines after learning. Science 344(6188): 1173-1178.

9. Q Qiao, C Wu, L. Ma, H Zhang, M Li, X Wu, WB Gan. Motor learning-induced new dendritic spines are preferentially involved in the learned task than existing spines. Cell Reports. 2022 Aug 16;40 (7), 111229  

10. Zhong H, Ceballos CC, Massengill CI, Muniak MA, L. Ma, Qin M, Petrie SK, Mao T. High-fidelity, efficient, and reversible labeling of endogenous proteins using CRISPR-based designer exon insertion. eLife. 2021 Jun 8;10. 

11. Bai Y, Li M, Zhou Y, L. Ma, Qiao Q, Hu W, Li W, Wills ZP, Gan WB. Abnormal dendritic calcium activity and synaptic depotentiation occur early in a mouse model of Alzheimer's disease. Molecular Neurodegeneration. 2017 Nov 14;12(1):86.