廉腾飞，中国药科大学教授、博士生导师，入选国家级高层次青年人才项目。2017年博士毕业于北京大学，2017年10月进入美国National Institutes of Health进行博士后研究，2024年12月加入中国药科大学生命科学与技术学院。长期致力于利用生物化学、分子生物学、结构生物学、计算生物学等方法探究重大疾病相关的药物靶标蛋白的工作机理，以此为基础进行新药靶点的发现以及药物设计。近年来以第一或通讯作者在Nature Structural & Molecular Biology、Molecular Cell、Nature Communications、Developmental Cell等国际知名学术期刊发表多篇论文。热忱欢迎优秀硕士、博士研究生、博士后等加盟合作。
药物靶点蛋白的工作机理
新药靶点发现以及药物设计
Tengfei Lian#, Ruifang Guan, Bing-Rui Zhou, Yawen Bai. Structural mechanism of synergistic targeting of CX3CR1 nucleosome by PU.1 and C/EBPa. Nature Structural & Molecular Biology, 31, 633–643 (2024) (#First author and co-corresponding author，第一作者兼共同通讯作者).
Ruifang Guan*, Tengfei Lian*, Bing-Rui Zhou, Yawen Bai. Structural mechanism of LIN28B nucleosome targeting by OCT4. Molecular Cell, 83, no 12 (2023): 1970-1982 (*Co-first authors).
Tongyi Dou, Tengfei Lian, Shi Shu, Yi He, Jiansen Jiang. The substrate and inhibitor binding mechanism of polyspecific transporter OAT1 revealed by high-resolution cryo-EM. (Nature Structural & Molecular Biology), 2023.
Pengxiang Huang*, Bradley M. Wierbowski*, Tengfei Lian*, Charlene Chan, Sara Garcia-Linares, Jiansen Jiang, Adrian Salic. Structural basis of Hedgehog ligand-receptor complex assembly catalyzed by a lipid-binding coreceptor. Developmental Cell, 2022 Feb 25:S1534-5807(22)00074-0 (*Co-first authors)
Ruifang Guan*, Tengfei Lian*, Bing-Rui Zhou, Emily He, Carl Wu, Martin Singleton, and Yawen Bai. Structural and dynamic mechanisms of CBF3-guided centromeric nucleosome formation. Nature communications 12, no. 1 (2021): 1-10. (*Co-first authors)
Guardia, Carlos M*, Xiao-Feng Tan*, Tengfei Lian*, Mitra S. Rana*, Wenchang Zhou, Eric T. Christenson, Augustus J. Lowry, Jose D. Faraldo-Gómez, Juan S. Bonifacino, Jiansen Jiang, and Anirban Banerjee, Structure of Human ATG9A, the Only Transmembrane Protein of the Core Autophagy Machinery. Cell Reports 31, no. 13 (2020): 107837. (*Co-first authors)
Rui Ma, Tengfei Lian, Rick Huang, Jonathan P. Renn, Jennifer D. Petersen, Joshua Zimmerberg, Patrick E. Duffy, and Niraj H. Tolia. Structural basis for placental malaria mediated by Plasmodium falciparum VAR2CSA. Nature Microbiology 6, no. 3 (2021): 380-391.
Tengfei Lian*, Yong-ping Xu*, Lan-fen Li, Xiao-dong Su, (2017) Crystal Structure of tetrameric Arabidopsis MYC2 reveals the mechanism of enhanced interaction with DNA, Cell Reports, 19:1334-1342. (*Co-first authors)
Jian-shi Jin*, Tengfei Lian*, Chan Gu*, Kai Yu, Yi Qin Gao, Xiao-Dong Su, (2016) The effects of cytosine methylation on general transcriptional factors, Scientific Reports, 6:29119. (* Co- first authors)
Jian-shi Jin, Tengfei Lian, X. Sunney Xie, Xiao-Dong Su, (2014) High-accuracy mapping protein binding stability on nucleosomal DNA using single-molecule method, Journal of Molecular Cell Biology, 6(5):438-40.
