药物靶点蛋白的工作机理
新药靶点发现以及药物设计
Tengfei Lian#, Ruifang Guan, Bing-Rui Zhou, Yawen Bai. Structural mechanism of synergistic targeting of CX3CR1 nucleosome by PU.1 and C/EBPa. Nature Structural & Molecular Biology, 31, 633–643 (2024) (#First author and co-corresponding author，第一作者兼共同通讯作者).
Ruifang Guan*, Tengfei Lian*, Bing-Rui Zhou, Yawen Bai. Structural mechanism of LIN28B nucleosome targeting by OCT4. Molecular Cell, 83, no 12 (2023): 1970-1982 (*Co-first authors).
Tongyi Dou, Tengfei Lian, Shi Shu, Yi He, Jiansen Jiang. The substrate and inhibitor binding mechanism of polyspecific transporter OAT1 revealed by high-resolution cryo-EM. (Nature Structural & Molecular Biology), 2023.
Pengxiang Huang*, Bradley M. Wierbowski*, Tengfei Lian*, Charlene Chan, Sara Garcia-Linares, Jiansen Jiang, Adrian Salic. Structural basis of Hedgehog ligand-receptor complex assembly catalyzed by a lipid-binding coreceptor. Developmental Cell, 2022 Feb 25:S1534-5807(22)00074-0 (*Co-first authors)
Ruifang Guan*, Tengfei Lian*, Bing-Rui Zhou, Emily He, Carl Wu, Martin Singleton, and Yawen Bai. Structural and dynamic mechanisms of CBF3-guided centromeric nucleosome formation. Nature communications 12, no. 1 (2021): 1-10. (*Co-first authors)
Guardia, Carlos M*, Xiao-Feng Tan*, Tengfei Lian*, Mitra S. Rana*, Wenchang Zhou, Eric T. Christenson, Augustus J. Lowry, Jose D. Faraldo-Gómez, Juan S. Bonifacino, Jiansen Jiang, and Anirban Banerjee, Structure of Human ATG9A, the Only Transmembrane Protein of the Core Autophagy Machinery. Cell Reports 31, no. 13 (2020): 107837. (*Co-first authors)
Rui Ma, Tengfei Lian, Rick Huang, Jonathan P. Renn, Jennifer D. Petersen, Joshua Zimmerberg, Patrick E. Duffy, and Niraj H. Tolia. Structural basis for placental malaria mediated by Plasmodium falciparum VAR2CSA. Nature Microbiology 6, no. 3 (2021): 380-391.
Tengfei Lian*, Yong-ping Xu*, Lan-fen Li, Xiao-dong Su, (2017) Crystal Structure of tetrameric Arabidopsis MYC2 reveals the mechanism of enhanced interaction with DNA, Cell Reports, 19:1334-1342. (*Co-first authors)
Jian-shi Jin*, Tengfei Lian*, Chan Gu*, Kai Yu, Yi Qin Gao, Xiao-Dong Su, (2016) The effects of cytosine methylation on general transcriptional factors, Scientific Reports, 6:29119. (* Co- first authors)
Jian-shi Jin, Tengfei Lian, X. Sunney Xie, Xiao-Dong Su, (2014) High-accuracy mapping protein binding stability on nucleosomal DNA using single-molecule method, Journal of Molecular Cell Biology, 6(5):438-40.
