支旭，男，中国药科大学生命科学与技术学院特聘副研究员，硕士生导师。硕士毕业于东南大学（导师：钱鹰教授），博士毕业于南京大学（导师：沈珍教授）。本课题组长期围绕活体功能成像、机制探索方面存在的难题，开展“化学材料-医学影像-机制研究”交叉融合的医学成像前沿研究。运用交叉学科方法，设计合成智能响应型小分子药物，用于活体及细胞内的靶向示踪、高分辨成像与治疗，并阐明其深层生物学机制，为药物研发提供新理论与新工具。近年来以第一或通讯作者在Chem. Eng. J.、Angew. Chem. Int. Ed.、Adv. Healthcare Mater.等国际知名期刊发表多篇研究论文。热忱欢迎对影像学、生化药学等学科感兴趣的本科生、研究生加入我们课题组。
活体分子影像探针开发：荧光、光声、PET、MRI等成像方法
靶向药物开发：新药筛选，信号通路、机制研究
诊疗一体化新药开发：肿瘤成像、心血管动脉粥样硬化等疾病研究
中国药科大学高层次人才科研启动经费（主持）
Xu Zhi, Fangjian Cai, Xiang Ming Yi, Lei Zhang*, Aiping Wang, Zhen Shen*. Trident anchoring-lipid droplets strategy for fluorescence/super-resolution/lifetime imaging and diagnosis of fatty liver in vivo. Chem. Eng. J., 2024, 490, 151810.
Xu Zhi, Yufen Sun, Fangjian Cai, Sisi Wang, Hu Gao, Fan Wu*, Lei Zhang*, Zhen Shen*. Oxidized Low-Density Lipoprotein (Ox-LDL)-Triggered Double-Lock Probe for Spatiotemporal Lipoprotein Oxidation and Atherosclerotic Plaque Imaging. Adv. Healthcare Mater., 2023, 2301595.
Hu Gao+, Xu Zhi+, Fan Wu*, Yue Zhao, Fangjian Cai, Pengfei Li, Zhen Shen*. Molecular Engineering of Corrole Radicals by Polycyclic Aromatic Fusion: Towards Open-Shell Near-Infrared Materials for Efficient Photothermal Therapy. Angew. Chem. Int. Ed., 2023, e202309208.
Yufeng Zhou, Jianan Dai, Jinzhi Qi, Jichun Wu, Yubo Huang, Baoxing Shen*, Xu Zhi*, Fu, Yongqian*. Construction of a red emission fluorescent probe for selectively detection of cysteine in living cells. Spectrochim. Acta, Part A, 2023, 286, 121946.
Xu Zhi, Ying Qian*. A novel red-emission phenothiazine fluorescent protein chromophore based on oxygen‒chlorine bond (O–Cl) formation for real-time detection of hypochlorous acid in cells. Talanta, 2021, 222, 121503.
Xu Zhi, Wenhui Xiang, Ying Qian*. Modulation of fluorescent protein chromophore for photodynamic therapy and two-photon fluorescent imaging in living cells. J. Lumin., 2021, 240, 118424.
Xu Zhi, Baoxing Shen, Ying Qian*. A novel carbazolyl GFP chromophore analogue: synthesis strategy and acidic pH-activatable lysosomal probe for tracing endogenous viscosity changes. New J. Chem., 2020, 44, 8823.
沈珍; 支旭; 张蕾,一种检测OX-LDL的探针前药和探针及其检测血管动脉粥样硬化的应用, CN116836188A。(中国发明专利)
