活体分子影像探针开发：荧光、光声、PET、MRI等成像方法
靶向药物开发：新药筛选，信号通路、机制研究
诊疗一体化新药开发：肿瘤成像、心血管动脉粥样硬化等疾病研究
活体分子影像探针开发：荧光、光声、PET、MRI等成像方法
靶向药物开发：新药筛选，信号通路、机制研究
诊疗一体化新药开发：肿瘤成像、心血管动脉粥样硬化等疾病研究
中国药科大学高层次人才科研启动经费（主持）
Xu Zhi, Fangjian Cai, Xiang Ming Yi, Lei Zhang*, Aiping Wang, Zhen Shen*. Trident anchoring-lipid droplets strategy for fluorescence/super-resolution/lifetime imaging and diagnosis of fatty liver in vivo. Chem. Eng. J., 2024, 490, 151810.
Xu Zhi, Yufen Sun, Fangjian Cai, Sisi Wang, Hu Gao, Fan Wu*, Lei Zhang*, Zhen Shen*. Oxidized Low-Density Lipoprotein (Ox-LDL)-Triggered Double-Lock Probe for Spatiotemporal Lipoprotein Oxidation and Atherosclerotic Plaque Imaging. Adv. Healthcare Mater., 2023, 2301595.
Hu Gao+, Xu Zhi+, Fan Wu*, Yue Zhao, Fangjian Cai, Pengfei Li, Zhen Shen*. Molecular Engineering of Corrole Radicals by Polycyclic Aromatic Fusion: Towards Open-Shell Near-Infrared Materials for Efficient Photothermal Therapy. Angew. Chem. Int. Ed., 2023, e202309208.
Yufeng Zhou, Jianan Dai, Jinzhi Qi, Jichun Wu, Yubo Huang, Baoxing Shen*, Xu Zhi*, Fu, Yongqian*. Construction of a red emission fluorescent probe for selectively detection of cysteine in living cells. Spectrochim. Acta, Part A, 2023, 286, 121946.
Xu Zhi, Ying Qian*. A novel red-emission phenothiazine fluorescent protein chromophore based on oxygen‒chlorine bond (O–Cl) formation for real-time detection of hypochlorous acid in cells. Talanta, 2021, 222, 121503.
Xu Zhi, Wenhui Xiang, Ying Qian*. Modulation of fluorescent protein chromophore for photodynamic therapy and two-photon fluorescent imaging in living cells. J. Lumin., 2021, 240, 118424.
Xu Zhi, Baoxing Shen, Ying Qian*. A novel carbazolyl GFP chromophore analogue: synthesis strategy and acidic pH-activatable lysosomal probe for tracing endogenous viscosity changes. New J. Chem., 2020, 44, 8823.
沈珍; 支旭; 张蕾,一种检测OX-LDL的探针前药和探针及其检测血管动脉粥样硬化的应用, CN116836188A。(中国发明专利)
