1. RNA修饰在肿瘤发生过程中的作用机制及探究其作为基因检测标记物的潜质；

2. 分子层面探究生物大分子（如剪接体，核糖体及RNA-蛋白复合物）的缺陷与疾病早期的关系。

·中国药科大学高层次人才科研启动经费（主持）

·Wang, C., Tay, L., Hu, W., Corre, M., & Graille, M. (2025). TRMT112, a master activator of several methyltransferases modifying factors involved in RNA maturation and translation. Frontiers in RNA research, doi: 10.3389/frnar.2025.1556979.

·Wang, C., Ulryck, N., Herzel, L., Pythoud, N., Kleiber, N., Guerineau, V., Jactel, V., Moritz, C., Bohnsack, M. T., Carapito, C., Touboul, D., Bohnsack, K. E., & Graille, M. (2023). N 2-methylguanosine modifications on human tRNAs and snRNA U6 are important for cell proliferation, protein translation and pre-mRNA splicing. Nucleic Acids Res, 51(14), 7496-7519. https://doi.org/10.1093/nar/gkad487

·Wang, C., van Tran, N., Jactel, V., Guerineau, V., & Graille, M. (2020). Structural and functional insights into Archaeoglobus fulgidus m2G10 tRNA methyltransferase Trm11 and its Trm112 activator. Nucleic Acids Res, 48(19), 11068-11082. https://doi.org/10.1093/nar/gkaa830