中国药科大学生命科学与技术学院二级教授、博导。国家杰出青年基金获得者、国务院政府特殊津贴获得者、中科院“百人计划”获得者、新世纪百千万人才工程国家级人选、国务院突出贡献中青年专家、国家重点研发计划项目负责人、江苏省“双创团队”领军人才、中国药科大学兴药杰出科学家。现任中国病理生理学会蛋白质修饰与疾病专业委员会副主委、江苏省生物技术学会副理事长等职。
长期聚焦于发现并解析宿主模式识别受体的特异性识别、细胞信号转导关键通路的组成与动态变化、早期免疫应答反应的时空特性，阐释固有免疫与急性炎症相关的分子调控机制。特别关注泛素与类泛素化修饰调控固有免疫和炎症的新功能与新机制，并从天然小分子化合物库中筛选并研究调控相关通路的先导化合物。在Nature，Cell，Immunity，Nature Immunology，PNAS，Autophagy，Journal of Cell Biology，Cell Reports，PLOS Pathogens，Molecular and Cellular Biology等期刊发表研究论文100余篇，他引超过8000余次；主编《泛素家族介导的蛋白质降解和细胞自噬》等著作。
1. 国家自然科学基金委员会, 面上项目, 82171751, 自噬下调cGAS-STING信号的新功能与分子机制研究, 2022-01-01 至 2025-12-31, 60万元, 在研, 主持
2. 中华人民共和国科学技术部, 国家重点研发计划, 2021YFF0702000, 基于新靶点的重大传染病人源化 动物模型研发, 2021-12 至 2025-11, 365万元, 在研, 主持
3. 国家自然科学基金委员会，创新研究群体项目，82321005，代谢调控与药物靶标发现，2024-01-01至2028-12-31，1000万元，在研，参与
4. 中华人民共和国科学技术部,国家重点研发计划, 2022YFC2303200, 重要感染中病原-共生微生物-宿 主互作和干预, 2022-12 至 2025-11, 122.5万元, 在研, 参与
5. 国家自然科学基金委员会, 重点项目, 31730018, cGAS-STING信号转导通路的调控新机制及相关先导 化合物研究, 2018-01-01 至 2022-12-31, 308万元, 资助期满, 主持
1. Mingyu Pan; Tongyu Hu; Jiao Lyu; Yue Yin; Jing Sun; Quanyi Wang; Lingxiao Xu; Haiyang Hu; Chen Wang; CSNK1A1/CK1α suppresses autoimmunity by restraining the CGAS-STING1 signaling, Autophagy, 2024, 20(3)
2. Ze Hong; Saihua Chen; Jing Sun; Dan Cheng; Hanli Guo; Jiahao Mei; Xiang Zhang; Munire Maimaiti; Haiping Hao; Peng Cao; Haiyang Hu; Chen Wang; STING signaling in islet macrophages impairs insulin secretion in obesity, Sci China Life Sci, 2023, Oct(25)
3. Mingyu Pan; Yue Yin; Tongyu Hu; Xinxia Wang; Tian Jia; Jing Sun; Quanyi Wang; Wei Meng; Juanjuan Zhu; Chunsun Dai; Haiyang Hu; Chen Wang ; UXT attenuates the CGAS-STING1 signaling by targeting STING1 for autophagic degradation, Autophagy, 2022, 19(2)
4. Ze Hong; Jiahao Mei; Chenhui Li; Guohui Bai; Munire Maimaiti; Haiyang Hu; Wenying Yu; Li Sun; Lele Zhang; Dan Cheng; Yixian Liao; Senlin Li; Yanping You; Hongbin Sun; Jing Huang; Xing Liu; Judy Lieberman; Chen Wang; STING inhibitors target the cyclic dinucleotide binding pocket, Proc Natl Acad Sci U S A, 2021, 118(24)
5. Chenhui Li; Lele Zhang; Dong Qian; Mingxing Cheng; Haiyang Hu; Ze Hong; Ye Cui; Huansha Yu; Quanyi Wang; Juanjuan Zhu; Wei Meng; Jinfu Xu; Yi Sun; Peng Zhang; Chen Wang ; RNF111- facilitated Neddylation Potentiates cGAS-mediated Antiviral Innate Immune Response, PLOS Pathogens, 2021, 17(3)
6. Ze Hong; Tianchi Ma; Xing Liu; Chen Wang; cGAS‐STING pathway: post‐translational modifications and functions in sterile inflammatory diseases, The FEBS Journal, 2021, 289(20)
7. Shufang Cui; Qiuya Yu; Lei Chu; Ye Cui; Ming Ding; Quanyi Wang; Hongyun Wang; Yu Chen; Xing Liu; Chen Wang ; Nuclear cGAS Functions Non-canonically to Enhance Antiviral Immunity via Recruiting Methyltransferase Prmt5, Cell Reports, 2020, 33(10)
8. Mingyu Pan; Yue Yin; Xinxia Wang; Quanyi Wang; Lele Zhang; Haiyang Hu; Chen Wang ; Mice deficient in UXT exhibit retinitis pigmentosa-like features via aberrant autophagy activation, Autophagy, 2020, 17(8)
9. Lele Zhang; Ning Wei; Ye Cui; Ze Hong; Xing Liu; Qiang Wang; Senlin Li; Heng Liu; Huansha Yu; Yanni Cai; Quanyi Wang; Juanjuan Zhu; Wei Meng; Zhengjun Chen; Chen Wang; The deubiquitinase CYLD is a specific checkpoint of the STING antiviral signaling pathway, PLoS Pathogens, 2018, 14(11)
10. Senlin Li; Ze Hong; Zhe Wang; Fei Li; Jiahao Mei; Lulu Huang; Xiwen Lou; Simeng Zhao; Lihua Song; Wei Chen; Qiang Wang; Heng Liu; Yanni Cai; Huansha Yu; Huimin Xu; Guangzhi Zeng; Quanyi Wang; Juanjuan Zhu; Xing Liu; Ninghua Tan; Chen Wang; The cyclopeptide Astin C specifically inhibits the innate immune CDN sensor STING, Cell Reports, 2018, 25(12)
