1、mRNA疫苗在内的各种新型疫苗研制；

2、自身免疫性疾病（IBD,T1D等）发病机理与靶标发现；

3、肠道微生物与疾病。

l 国家自然科学基金面上项目（NETs在溃疡性结肠炎肠道粘膜损伤中的致病机理及干预研究，No：81973224）

l 国家自然科学基金面上项目（葡萄球菌核酸酶介导NETs降解在T1DM防治中的作用机制研究，No：81673340）

l 国家自然科学基金面上项目（乳酸菌在粘膜给药疫苗递呈载体中的应用，No：81172973）

l 江苏省基础研究计划（自然科学基金）（乳酸菌递呈的葡萄球菌核酸酶在T1DM防治中的作用与机制研究，No：BK20161462）

l 国家自然科学基金青年基金（疫苗多肽纳米载药新分子的研究，No：30500458）

1. Shi R, Tao Y, Tang H, Wu C, Fei J, Ge H, Gu HF*, Wu J*, Abelmoschus Manihot ameliorates the levels of circulating metabolites in diabetic 2 nephropathy by modulating gut microbiota in NOD mice. Microbial Biotechnology 2023 Apr;16(4): 813–826

2. Wu C, Song Y, Yu Y, Xu Q, Cui X, Wang Y, Wu J*, Gu HF*. Single-Cell Transcriptional Landscape Reveals the Regulatory Network and Its Heterogeneity of Renal Mitochondrial Damages in Diabetic Kidney Disease. Int J Mol Sci. 2023 Aug 31;24(17):13502

3. Wang P†, Liu D†, Zhou Z, Liu F, Shen Y, You Q, Lu S*, Wu J*,The role of protein arginine deiminase 4-dependent neutrophil extracellular traps formation in ulcerative colitis. Front Immunol 2023,14: 1144976

4. You Q,  Shen Y,  Wu Y,  Li Y,  Liu C,  Huang F,  Gu HF*,  Wu J*, Neutrophil Extracellular Traps Caused by Gut Leakage Trigger the Autoimmune Response in Nonobese Diabetic Mice. Front Immunol 2022,12:711423

5. Shen Y,  You Q,  Wu Y,  Wu J*, Inhibition of PAD4-mediated NET formation by clamidine prevents diabetes development in nonobese diabetic mice, Eur J Pharmacol 2021 Nov 09

6. Dong W, Liu D, Zhang T, You Q, Huang F, Wu J*，Oral delivery of staphylococcal nuclease ameliorates DSS induced ulcerative colitis in mice via degrading intestinal neutrophil extracellular traps，Ecotoxicology and Environmental Safety，2021，215：112161

7. Chen Y, Wu J, Wang J, Zhang W, Xu B, Xu X, Zong L*Targeted delivery of antigen to intestinal dendritic cells induces oral tolerance and prevents autoimmune diabetes in NOD mice，Diabetologia，2018 Jun;61(6):1384-96

8. Lang J, Wang X, Liu K, He D, Niu P, Cao R, Jin L, Wu J*. Oral delivery of staphylococcal nuclease by Lactococcus lactis prevents type 1 diabetes mellitus in NOD mice.Appl Microbiol Biotechnol. 2017 Sep, 101:7653–62