王中原，理学博士。教授、博导。2007年于吉林大学获学士学位，2010年于吉林大学获硕士学位，2014年于清华大学获博士学位。2014-2021年就职于深圳大学医学部基础医学院，期间赴美国加州大学尔湾分校和哈佛医学院访学一年。2021年起任中国药科大学生命科学与技术学院教授，博士生导师。主要从事蛋白质修饰与稳态在肿瘤、衰老等生理、病理过程中的机制研究，并开发具有高度靶向性的先导化合物，为疾病治疗提供全新的方案和策略。
| 肿瘤发生、发展的机制研究及药物靶向治疗 |
目前正主持中国药科大学高层次人才启动经费项目，国家自然科学基金面上项目等。
1. Zhongyuan Wang#, Liang Zhou#, Yejun Wang, Quanzhou Peng, Huan Li, Xin Zhang, Zijie Su, Jiaxing Song, Qi Sun, Sapna Sayed, Shanshan Liu, Desheng Lu*. The CK1δ/ε-AES axis regulates tumorigenesis and metastasis in colorectal cancer. Theranostics, 2021, 11(9): 4421-4435.
2. Zhongyuan Wang#, Liang Zhou#, Yanpeng Xiong, Shubin Yu, Huan Li, Jiaoyang Fan, Fan Li, Zijie Su, Jiaxing Song, Qi Sun, Shan-Shan Liu, Yuqing Xia, Liang Zhao, Shiyue Li, Fang Guo, Peng Huang, Dennis A. Carson*, and Desheng Lu*. Salinomycin exerts anti-colorectal cancer activity by targeting the β-catenin/TCF complex. Br J Pharmacol, 2019,176(17):3390-3406.
3. Zijie Su#, Jiaxing Song#, Zhongyuan Wang#, Liang Zhou, Yuqing Xia, Shubin Yu, Qi Sun, Shan-shan Liu, Liang Zhao, Shiyue Li, Lei Wei, Dennis A. Carson*, Desheng Lu*. Tumor promoter TPA activates Wnt/β-catenin signaling in a casein kinase 1-dependent manner. Proc Natl Acad Sci U S A, 2018, 115(32): E7522-E7531.
4. Zhongyuan Wang#, Bo Li#, Liang Zhou, Shubin Yu, Zijie Su, Jiaxing Song, Qi Sun,a Ou Sha, Xiaomei Wang, Wenqi Jiang, Karl Willert, Lei Wei, Dennis A. Carson*, Desheng Lu*. Prodigiosin inhibits Wnt/β-catenin signaling and exerts anticancer activity in breast cancer cells. Proc Natl Acad Sci U S A, 2016, 113(46): 13150-13155.
5. Zhongyuan Wang#, Yanping Wu#, Haifeng Wang, Yangqing Zhang, Lin Mei, Xuexun Fang, Xudong Zhang, Fang Zhang, Hongbo Chen, Ying Liu, Yuyang Jiang, Shengnan Sun, Yi Zheng, Na Li, Laiqiang Huang*. Interplay of mevalonate and Hippo pathways regulates RHAMM transcription via YAP to modulate breast cancer cell motility. Proc Natl Acad Sci U S A, 2014, 111(1): E89-98. (Selected as Editors’ Choice of Science Signaling)
