Peng L#, Xiang S#, Wang T, Yang M, Duan Y, Ma X, Li S, Yu C, Zhang X, Hu H, Liu Z, Sun J, Sun C, Wang C, Liu B*, Wang Z*, Qian M*. The hepatic clock orchestrates with HIF-1a to coordinate nucleotide availability during liver damage repair. Nature Metabolism, 2025 Jan;7(1):148-165.
Wang K#, Zhang X#, Fan Y, Zhou L, Duan Y, Li S, Sun Z, Zhang C, Yang H, Yuan W, Peng L, Ma X, Xiang S, Wang T, Yang M, Zhang Z, Wang J, Wang Z*, Qian M*. Reactivation of MAPK-SOX2 pathway confers ferroptosis sensitivity in KRASG12C inhibitor resistant tumors. Redox Biology, 2024 Dec;78:103419.
Zhang X#, Duan Y#, Li S, Zhang Z, Peng L, Ma X, Wang T, Xiang S, Chen G, Zhou D, Lu D*, Qian M*, Wang Z*. CRISPR screening identifies PRMT1 as a key pro-ferroptotic gene via a two-layer regulatory mechanism. Cell Reports, 2024 Sep 24;43(9):114662.
Peng L#, Zhou L#, Li H, Zhang X, Li S, Wang K, Yang M, Ma X, Zhang D, Xiang S, Duan Y, Wang T, Sun C, Wang C, Lu D*, Qian M*, Wang Z*. Hippo signaling-controlled MHC-I antigen processing and presentation pathway potentiates antitumor immunity. Cell Reports, 2024 Apr 23;43(4):114003.
Wang Z#, Zhou L#, Wang Y, Peng Q, Li H, Zhang X, Su Z, Song J, Sun Q, Sayed S, Liu S, Lu D*. The CK1δ/ε-AES axis regulates tumorigenesis and metastasis in colorectal cancer. Theranostics, 2021, 11(9): 4421-4435.
Wang Z#, Zhou L#, Xiong Y, Yu S, Li H, Fan J, Li F, Su Z, Song J, Sun Q, Liu S, Xia Y, Zhao L, Li S, Guo F, Huang P, Carson D*, Lu D*. Salinomycin exerts anti-colorectal cancer activity by targeting the β-catenin/TCF complex. Br J Pharmacol, 2019,176(17):3390-3406.
Su Z#, Song J#, Wang Z#, Zhou L, Xia Y, Yu S, Sun Q, Liu S, Zhao L, Li S, Wei L, Carson D*, Lu D*. Tumor promoter TPA activates Wnt/β-catenin signaling in a casein kinase 1-dependent manner. Proc Natl Acad Sci U S A,2018, 115(32): E7522-E7531.
Wang Z#, Li B#, Zhou L, Yu S, Su Z, Song J, Sun Q, Sha O, Wang X, Jiang W, Willert K, Wei L, Carson D*, Lu D*. Prodigiosin inhibits Wnt/β-catenin signaling and exerts anticancer activity in breast cancer cells. Proc Natl Acad Sci U S A,2016, 113(46): 13150-13155.
肿瘤发生、发展的机制研究及靶向治疗
衰老的分子机制和干预研究
主持多项国家自然科学基金项目、省部级项目及中国药科大学高层次人才启动经费项目等
Peng L#, Xiang S#, Wang T, Yang M, Duan Y, Ma X, Li S, Yu C, Zhang X, Hu H, Liu Z, Sun J, Sun C, Wang C, Liu B*, Wang Z*, Qian M*. The hepatic clock orchestrates with HIF-1a to coordinate nucleotide availability during liver damage repair. Nature Metabolism, 2025 Jan;7(1):148-165.
Wang K#, Zhang X#, Fan Y, Zhou L, Duan Y, Li S, Sun Z, Zhang C, Yang H, Yuan W, Peng L, Ma X, Xiang S, Wang T, Yang M, Zhang Z, Wang J, Wang Z*, Qian M*. Reactivation of MAPK-SOX2 pathway confers ferroptosis sensitivity in KRASG12C inhibitor resistant tumors. Redox Biology, 2024 Dec;78:103419.
Zhang X#, Duan Y#, Li S, Zhang Z, Peng L, Ma X, Wang T, Xiang S, Chen G, Zhou D, Lu D*, Qian M*, Wang Z*. CRISPR screening identifies PRMT1 as a key pro-ferroptotic gene via a two-layer regulatory mechanism. Cell Reports, 2024 Sep 24;43(9):114662.
Peng L#, Zhou L#, Li H, Zhang X, Li S, Wang K, Yang M, Ma X, Zhang D, Xiang S, Duan Y, Wang T, Sun C, Wang C, Lu D*, Qian M*, Wang Z*. Hippo signaling-controlled MHC-I antigen processing and presentation pathway potentiates antitumor immunity. Cell Reports, 2024 Apr 23;43(4):114003.
Wang Z#, Zhou L#, Wang Y, Peng Q, Li H, Zhang X, Su Z, Song J, Sun Q, Sayed S, Liu S, Lu D*. The CK1δ/ε-AES axis regulates tumorigenesis and metastasis in colorectal cancer. Theranostics, 2021, 11(9): 4421-4435.
Wang Z#, Zhou L#, Xiong Y, Yu S, Li H, Fan J, Li F, Su Z, Song J, Sun Q, Liu S, Xia Y, Zhao L, Li S, Guo F, Huang P, Carson D*, Lu D*. Salinomycin exerts anti-colorectal cancer activity by targeting the β-catenin/TCF complex. Br J Pharmacol, 2019,176(17):3390-3406.
Su Z#, Song J#, Wang Z#, Zhou L, Xia Y, Yu S, Sun Q, Liu S, Zhao L, Li S, Wei L, Carson D*, Lu D*. Tumor promoter TPA activates Wnt/β-catenin signaling in a casein kinase 1-dependent manner. Proc Natl Acad Sci U S A,2018, 115(32): E7522-E7531.
Wang Z#, Li B#, Zhou L, Yu S, Su Z, Song J, Sun Q, Sha O, Wang X, Jiang W, Willert K, Wei L, Carson D*, Lu D*. Prodigiosin inhibits Wnt/β-catenin signaling and exerts anticancer activity in breast cancer cells. Proc Natl Acad Sci U S A,2016, 113(46): 13150-13155.
