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王中原
职称:教授
邮箱:wangzhongyuan@cpu.edu.cn
学院:生命科学与技术学院
实验室:江宁校区学院实验楼一期325室
招生学科:生物学,微生物与生化药学
办公室:江宁校区学院实验楼一期303室
个人简历

目前正主持中国药科大学高层次人才启动经费项目,国家自然科学基金面上项目等。


研究方向


肿瘤发生、发展的机制研究及药物靶向治疗


主持在研项目情况

目前正主持中国药科大学高层次人才启动经费项目,国家自然科学基金面上项目等。


近年代表性科研成果

1. Zhongyuan Wang#, Liang Zhou#, Yejun Wang, Quanzhou Peng, Huan Li, Xin Zhang, Zijie Su, Jiaxing Song, Qi Sun, Sapna Sayed, Shanshan Liu, Desheng Lu*. The CK1δ/ε-AES axis regulates tumorigenesis and metastasis in colorectal cancer. Theranostics, 2021, 11(9): 4421-4435.

2. Zhongyuan Wang#, Liang Zhou#, Yanpeng Xiong, Shubin Yu, Huan Li, Jiaoyang Fan, Fan Li, Zijie Su, Jiaxing Song, Qi Sun, Shan-Shan Liu, Yuqing Xia, Liang Zhao, Shiyue Li, Fang Guo, Peng Huang, Dennis A. Carson*, and Desheng Lu*. Salinomycin exerts anti-colorectal cancer activity by targeting the β-catenin/TCF complex. Br J Pharmacol, 2019,176(17):3390-3406.

3. Zijie Su#, Jiaxing Song#, Zhongyuan Wang#, Liang Zhou, Yuqing Xia, Shubin Yu, Qi Sun, Shan-shan Liu, Liang Zhao, Shiyue Li, Lei Wei, Dennis A. Carson*, Desheng Lu*. Tumor promoter TPA activates Wnt/β-catenin signaling in a casein kinase 1-dependent manner. Proc Natl Acad Sci U S A, 2018, 115(32): E7522-E7531.

4. Zhongyuan Wang#, Bo Li#, Liang Zhou, Shubin Yu, Zijie Su, Jiaxing Song, Qi Sun,a Ou Sha, Xiaomei Wang, Wenqi Jiang, Karl Willert, Lei Wei, Dennis A. Carson*, Desheng Lu*. Prodigiosin inhibits Wnt/β-catenin signaling and exerts anticancer activity in breast cancer cells. Proc Natl Acad Sci U S A, 2016, 113(46): 13150-13155.

5. Zhongyuan Wang#, Yanping Wu#, Haifeng Wang, Yangqing Zhang, Lin Mei, Xuexun Fang, Xudong Zhang, Fang Zhang, Hongbo Chen, Ying Liu, Yuyang Jiang, Shengnan Sun, Yi Zheng, Na Li, Laiqiang Huang*. Interplay of mevalonate and Hippo pathways regulates RHAMM transcription via YAP to modulate breast cancer cell motility. Proc Natl Acad Sci U S A, 2014, 111(1): E89-98. (Selected as Editors’ Choice of Science Signaling)